Prognostic factors associated with severe complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Huseyin Kemal Raşa; Ayhan Erdemir; Koray Topgül

Makale detayları

Prognostic factors associated with severe complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Yazarlar:

Huseyin Kemal Raşa | Ayhan Erdemir | Koray Topgül

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

General Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.768-774

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001302836

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 Cytoreductive surgery CRS and hyperthermic intraperitoneal chemotherapy HIPEC can significantly improve outcomes in certain peritoneal carcinomatosis patient groups but it is a complicated surgical procedure with high morbidity and mortality rates. Our study evaluated the preoperative and perioperative variables to understand whether any variable was associated with an increased risk of complications. We retrospectively evaluated thirty-three successive patients who underwent CRS and HIPEC between 2017 and 2020. Patients were assigned into Group 1 15 patients and Group 2 18 patients according to the severity of the complications. When the groups were compared in terms of age, gender, BMI, presence of the previous operation, presence of sarcopenia, primary malignancy, peritoneal cancer index, and cytoreduction completeness scores, no statistical differences were found. When the serum albumin levels in the preoperative and postoperative seventy-second hour were compared, both groups had a significant decrease p0.011 and p0.001, respectively. When the decrease rate of serum albumin levels was compared, there was no significant difference p0.539. There was a statistically significant difference between the preoperative and postoperative seventy-second-hour haemoglobin levels in both groups p0.01 and p0.00, respectively. When the groups were compared according to the decrease rate in haemoglobin levels fall was more pronounced in patients with more severe complications p0.036. We concluded that the decrease in albumin levels and haemoglobin levels in the perioperative period is important and that a significant decrease in haemoglobin levels in the first seventy-two hours may be a pioneering data in terms of the development of serious complications. Therefore, closer monitoring of those patients and being more proactive in their treatment can contribute to the prevention of serious complications that may develop.

 Cytoreductive surgery CRS and hyperthermic intraperitoneal chemotherapy HIPEC can significantly improve outcomes in certain peritoneal carcinomatosis patient groups but it is a complicated surgical procedure with high morbidity and mortality rates. Our study evaluated the preoperative and perioperative variables to understand whether any variable was associated with an increased risk of complications. We retrospectively evaluated thirty-three successive patients who underwent CRS and HIPEC between 2017 and 2020. Patients were assigned into Group 1 15 patients and Group 2 18 patients according to the severity of the complications. When the groups were compared in terms of age, gender, BMI, presence of the previous operation, presence of sarcopenia, primary malignancy, peritoneal cancer index, and cytoreduction completeness scores, no statistical differences were found. When the serum albumin levels in the preoperative and postoperative seventy-second hour were compared, both groups had a significant decrease p0.011 and p0.001, respectively. When the decrease rate of serum albumin levels was compared, there was no significant difference p0.539. There was a statistically significant difference between the preoperative and postoperative seventy-second-hour haemoglobin levels in both groups p0.01 and p0.00, respectively. When the groups were compared according to the decrease rate in haemoglobin levels fall was more pronounced in patients with more severe complications p0.036. We concluded that the decrease in albumin levels and haemoglobin levels in the perioperative period is important and that a significant decrease in haemoglobin levels in the first seventy-two hours may be a pioneering data in terms of the development of serious complications. Therefore, closer monitoring of those patients and being more proactive in their treatment can contribute to the prevention of serious complications that may develop.

 Cytoreductive surgery CRS and hyperthermic intraperitoneal chemotherapy HIPEC can significantly improve outcomes in certain peritoneal carcinomatosis patient groups but it is a complicated surgical procedure with high morbidity and mortality rates. Our study evaluated the preoperative and perioperative variables to understand whether any variable was associated with an increased risk of complications. We retrospectively evaluated thirty-three successive patients who underwent CRS and HIPEC between 2017 and 2020. Patients were assigned into Group 1 15 patients and Group 2 18 patients according to the severity of the complications. When the groups were compared in terms of age, gender, BMI, presence of the previous operation, presence of sarcopenia, primary malignancy, peritoneal cancer index, and cytoreduction completeness scores, no statistical differences were found. When the serum albumin levels in the preoperative and postoperative seventy-second hour were compared, both groups had a significant decrease p0.011 and p0.001, respectively. When the decrease rate of serum albumin levels was compared, there was no significant difference p0.539. There was a statistically significant difference between the preoperative and postoperative seventy-second-hour haemoglobin levels in both groups p0.01 and p0.00, respectively. When the groups were compared according to the decrease rate in haemoglobin levels fall was more pronounced in patients with more severe complications p0.036. We concluded that the decrease in albumin levels and haemoglobin levels in the perioperative period is important and that a significant decrease in haemoglobin levels in the first seventy-two hours may be a pioneering data in terms of the development of serious complications. Therefore, closer monitoring of those patients and being more proactive in their treatment can contribute to the prevention of serious complications that may develop.

 Cytoreductive surgery CRS and hyperthermic intraperitoneal chemotherapy HIPEC can significantly improve outcomes in certain peritoneal carcinomatosis patient groups but it is a complicated surgical procedure with high morbidity and mortality rates. Our study evaluated the preoperative and perioperative variables to understand whether any variable was associated with an increased risk of complications. We retrospectively evaluated thirty-three successive patients who underwent CRS and HIPEC between 2017 and 2020. Patients were assigned into Group 1 15 patients and Group 2 18 patients according to the severity of the complications. When the groups were compared in terms of age, gender, BMI, presence of the previous operation, presence of sarcopenia, primary malignancy, peritoneal cancer index, and cytoreduction completeness scores, no statistical differences were found. When the serum albumin levels in the preoperative and postoperative seventy-second hour were compared, both groups had a significant decrease p0.011 and p0.001, respectively. When the decrease rate of serum albumin levels was compared, there was no significant difference p0.539. There was a statistically significant difference between the preoperative and postoperative seventy-second-hour haemoglobin levels in both groups p0.01 and p0.00, respectively. When the groups were compared according to the decrease rate in haemoglobin levels fall was more pronounced in patients with more severe complications p0.036. We concluded that the decrease in albumin levels and haemoglobin levels in the perioperative period is important and that a significant decrease in haemoglobin levels in the first seventy-two hours may be a pioneering data in terms of the development of serious complications. Therefore, closer monitoring of those patients and being more proactive in their treatment can contribute to the prevention of serious complications that may develop.

Makale detayları

Prognostic factors associated with severe complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Yazarlar:

Huseyin Kemal Raşa | Ayhan Erdemir | Koray Topgül

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

General Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.768-774

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001302836

pISSN:

1309-4483

Cytoreduction surgical procedures

Hyperthermic intraperitoneal chemotherapy

Prognosis

Albumin

Haemoglobin

Postoperative complications

Sayı

Makale detayları

Prognostic factors associated with severe complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Yazarlar: Huseyin Kemal Raşa | Ayhan Erdemir | Koray Topgül

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: General Surgery

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.768-774

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001302836

pISSN: 1309-4483

Cytoreduction surgical procedures

Hyperthermic intraperitoneal chemotherapy

Prognosis

Albumin

Haemoglobin

Postoperative complications

Sayı

Yazarlar:

Huseyin Kemal Raşa | Ayhan Erdemir | Koray Topgül

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

General Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.768-774

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001302836

pISSN:

1309-4483