The Relationship between Carnitine Levels and Lipid Peroxidation in Glial Brain Tumors

Nilüfer BAYRAKTAR; Hatice PAŞAOĞLU; Aydın PAŞAOĞLU

Makale detayları

The Relationship between Carnitine Levels and Lipid Peroxidation in Glial Brain Tumors

Yazarlar:

Nilüfer BAYRAKTAR | Hatice PAŞAOĞLU | Aydın PAŞAOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 4, pp.293-299

Belge Tipi:

Makale

Yayın Tarihi:

3/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755751

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aim: It is assumed that reactive oxygen species and lipid peroxidation cause cell membrane damage and play a role in oncogenesis. Carnitine and acyl esters, which play a role in intracellular short-, medium-, and long-chain fatty acid metabolism, are one of the defense mechanisms against free radical toxicity. It is thought that the protective effects of carnitine are related with its role in lipid metabolism. In our study, we analyzed the relation between malondialdehyde (MDA) and free carnitine, and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 carnitine levels in glial tumors [glioblastoma multiforme (GBM) (n = 29), high-grade astrocytoma (n = 8) and low-grade astrocytoma (n = 8)] to determine whether there is a relation between carnitine-acyl carnitines and lipid peroxidation in carcinogenesis.   Materials and Methods: The present study examined the free carnitine and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 levels of glial tumors in tandem mass spectrometry. We measured MDA levels using HPLC system.   Results: There was a significant correlation between MDA and C20:4 carnitine levels in GBM. C20:4 carnitine levels increased with increasing MDA levels (p = 0.000, r = 0.916), but no significant correlation was found in the other groups.   Conclusions: In conclusion, measurement of only carnitine-MDA relation did not reflect any significant correlation. Detailed studies, including measurement of parameters showing antioxidant status and tumor cellular metabolism, are necessary.

 

Aim: It is assumed that reactive oxygen species and lipid peroxidation cause cell membrane damage and play a role in oncogenesis. Carnitine and acyl esters, which play a role in intracellular short-, medium-, and long-chain fatty acid metabolism, are one of the defense mechanisms against free radical toxicity. It is thought that the protective effects of carnitine are related with its role in lipid metabolism. In our study, we analyzed the relation between malondialdehyde (MDA) and free carnitine, and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 carnitine levels in glial tumors [glioblastoma multiforme (GBM) (n = 29), high-grade astrocytoma (n = 8) and low-grade astrocytoma (n = 8)] to determine whether there is a relation between carnitine-acyl carnitines and lipid peroxidation in carcinogenesis.   Materials and Methods: The present study examined the free carnitine and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 levels of glial tumors in tandem mass spectrometry. We measured MDA levels using HPLC system.   Results: There was a significant correlation between MDA and C20:4 carnitine levels in GBM. C20:4 carnitine levels increased with increasing MDA levels (p = 0.000, r = 0.916), but no significant correlation was found in the other groups.   Conclusions: In conclusion, measurement of only carnitine-MDA relation did not reflect any significant correlation. Detailed studies, including measurement of parameters showing antioxidant status and tumor cellular metabolism, are necessary.

Makale detayları

The Relationship between Carnitine Levels and Lipid Peroxidation in Glial Brain Tumors

Yazarlar: Nilüfer BAYRAKTAR | Hatice PAŞAOĞLU | Aydın PAŞAOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2008 Vol.38 Issue 4, pp.293-299

Belge Tipi: Makale

Yayın Tarihi: 3/2008

Belge Dili: Türkçe

Document ID (Org No.): 2000755751

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Carnitine

lipid peroxidation

tandem mass spectrometry

HPLC

Sayı

Yazarlar:

Nilüfer BAYRAKTAR | Hatice PAŞAOĞLU | Aydın PAŞAOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 4, pp.293-299

Belge Tipi:

Makale

Yayın Tarihi:

3/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755751

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144