Propolis and royal jelly containing skin cream: The evaluation of antioxidant, anti-hyaluronidase, and antimicrobial activities

Gülsüm Merve Boyracı; Atiye Değirmenci; Oktay Yıldız; Zeynep Berin Çelebi

Makale detayları

Propolis and royal jelly containing skin cream: The evaluation of antioxidant, anti-hyaluronidase, and antimicrobial activities

Yazarlar:

Gülsüm Merve Boyracı | Atiye Değirmenci | Oktay Yıldız | Zeynep Berin Çelebi

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Uludağ Arıcılık Dergisi Vol.23 Issue 2, pp.224-238

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001303772

pISSN:

2687-5594

Anahtar kelimeler:

Özet:

 Propolis and royal jelly have been utilized in both traditional and modern medical practices since earlier times, owing to their diverse range of biological properties. Recent research has demonstrated their potential application in the realm of skin treatment and care. The purpose of this study is to examine the potential application of propolis and royal jelly in cream formulation and to evaluate the impact of the utilized bee products on the creams anti-hyaluronidase, antioxidant, and antimicrobial activities. It is also investigate the physical stability of creams at various storage temperatures and durations. The cream formulation maintained ratio of royal jelly at 0.5, while varying amounts of propolis extract ranging from 0.5 to 1.0 to 1.5 were utilized. The pH values of the creams examined in the study ranged from 5.56 to 6.02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of the cream samples, the IC50 values were determined as 0.16672-3.34603 gml cream and the Cream 3 sample with 1.5 propolis extract showed the highest activity. The cream samples with propolis and royal jelly exhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testing indicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This research provides evidence of the feasibility of integrating bee products into cream formulations to enrich them with natural, sustainable and safe skin care products in the cosmetics industry.

 Propolis and royal jelly have been utilized in both traditional and modern medical practices since earlier times, owing to their diverse range of biological properties. Recent research has demonstrated their potential application in the realm of skin treatment and care. The purpose of this study is to examine the potential application of propolis and royal jelly in cream formulation and to evaluate the impact of the utilized bee products on the creams anti-hyaluronidase, antioxidant, and antimicrobial activities. It is also investigate the physical stability of creams at various storage temperatures and durations. The cream formulation maintained ratio of royal jelly at 0.5, while varying amounts of propolis extract ranging from 0.5 to 1.0 to 1.5 were utilized. The pH values of the creams examined in the study ranged from 5.56 to 6.02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of the cream samples, the IC50 values were determined as 0.16672-3.34603 gml cream and the Cream 3 sample with 1.5 propolis extract showed the highest activity. The cream samples with propolis and royal jelly exhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testing indicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This research provides evidence of the feasibility of integrating bee products into cream formulations to enrich them with natural, sustainable and safe skin care products in the cosmetics industry.

 Propolis and royal jelly have been utilized in both traditional and modern medical practices since earlier times, owing to their diverse range of biological properties. Recent research has demonstrated their potential application in the realm of skin treatment and care. The purpose of this study is to examine the potential application of propolis and royal jelly in cream formulation and to evaluate the impact of the utilized bee products on the creams anti-hyaluronidase, antioxidant, and antimicrobial activities. It is also investigate the physical stability of creams at various storage temperatures and durations. The cream formulation maintained ratio of royal jelly at 0.5, while varying amounts of propolis extract ranging from 0.5 to 1.0 to 1.5 were utilized. The pH values of the creams examined in the study ranged from 5.56 to 6.02, indicating that they were compatible with the pH value of the skin. It was observed that the antioxidant activity values increased statistically as the propolis ratio increased in the cream formulation. As a result of the antihyaluronidase activity analysis of the cream samples, the IC50 values were determined as 0.16672-3.34603 gml cream and the Cream 3 sample with 1.5 propolis extract showed the highest activity. The cream samples with propolis and royal jelly exhibited inhibitory activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. The results of accelerated stability testing indicate that the cream formulation exhibits exceptional stability when subjected to various stress situations. This research provides evidence of the feasibility of integrating bee products into cream formulations to enrich them with natural, sustainable and safe skin care products in the cosmetics industry.

 Propolis ve arı sütü eski çağlardan beri geleneksel ve modern tıpta çeşitli biyolojik aktivitelerinden dolayı kullanılmıştır. Günümüzde yapılan son çalışmalar bu ürünlerin cilt tedavisi ve bakımı alanındaki potansiyel uygulamalarını ortaya koymuştur. Bu çalışmanın amacı, cilt kremi üretiminde propolis ve arı sütünün potansiyel kullanımını incelemek ve arı ürünleriyle zenginleştirilmiş cilt kremi formülasyonunun anti-hiyalüronidaz, antioksidan ve antimikrobiyal aktivitesini değerlendirmektir. Ayrıca kremlerin farklı depolama sıcaklığı ve süresindeki fiziksel stabilitesi de incelenmiştir. Krem formülasyonunda arı sütü oranı 0,5 sabit tutulurken propolis özütü 0,5-1,0-1,5 oranlarında kullanılmıştır. Çalışmada üretilen kremlerin pH değerleri 5,56 ile 6,02 aralığında değişmekte olup cilt pH değerine uygun bulunmuştur. Krem formülasyonunda propolis oranı arttıkça antioksidan aktivite değerlerinin istatistiksel olarak arttığı görülmüştür p0,05. Krem örneklerinin anti-hiyalüronidaz aktivite analizi sonucu IC50 değerleri 0,1667-3,3460 gmL krem olarak belirlenmiş ve en yüksek aktivite 1,5 propolis özütü ilaveli örnekte bulunmuştur. Propolis ve arı sütü ilaveli krem örneklerinin tamamı Bacillus cereus, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis ve Candida albicans mikroorganizmalarına karşı inhibisyon göstermiştir. Hızlandırılmış stabilite testleri krem formülasyonun tüm stres koşullarına karşı dikkate değer bir stabiliteye sahip olduğunu göstermiştir. Bu çalışma kozmetik sektöründe doğal, sürdürülebilir ve güvenli cilt bakım ürünleri üretebilmek için krem formülasyonuna arı ürünlerini entegre etmenin uygulanabilirliğine dair kanıt sağlamaktadır.

Makale detayları

Propolis and royal jelly containing skin cream: The evaluation of antioxidant, anti-hyaluronidase, and antimicrobial activities

Yazarlar:

Gülsüm Merve Boyracı | Atiye Değirmenci | Oktay Yıldız | Zeynep Berin Çelebi

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Uludağ Arıcılık Dergisi Vol.23 Issue 2, pp.224-238

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001303772

pISSN:

2687-5594

Propolis

Royal jelly

Cream

Skin regenerating effect

Anti-hyaluronidase activityPropolis

Arı sütü

Krem

Cilt yenileyici etki

Anti-hiyaluronidaz aktivite

Sayı

Makale detayları

Yazarlar: Gülsüm Merve Boyracı | Atiye Değirmenci | Oktay Yıldız | Zeynep Berin Çelebi

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Kimya Mühendisliği (Diğer)

Dergi: Uludağ Arıcılık Dergisi Vol.23 Issue 2, pp.224-238

Belge Tipi: Makale

Yayın Tarihi: 11/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001303772

pISSN: 2687-5594

Sayı

Yazarlar:

Gülsüm Merve Boyracı | Atiye Değirmenci | Oktay Yıldız | Zeynep Berin Çelebi

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Uludağ Arıcılık Dergisi Vol.23 Issue 2, pp.224-238

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001303772

pISSN:

2687-5594