Synchronous and antecedent malignancies in patients with papillary thyroid carcinoma

Mehmet ÇELİK; Buket YILMAZ BÜLBÜL; Semra AYTÜRK; Ahmet KÜÇÜKARDA; Ebru TAŞTEKİN; Nuray CAN; Funda ÜSTÜN; Yavuz Atakan SEZER; Sibel GÜLDİKEN

doi:https://doi.org/10.18621/eurj.360833

Makale detayları

Synchronous and antecedent malignancies in patients with papillary thyroid carcinoma

Yazarlar:

Mehmet ÇELİK | Buket YILMAZ BÜLBÜL | Semra AYTÜRK | Ahmet KÜÇÜKARDA | Ebru TAŞTEKİN | Nuray CAN | Funda ÜSTÜN | Yavuz Atakan SEZER | Sibel GÜLDİKEN

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2018 Vol.4 Issue 3, pp.215-219

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000663195

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.360833

Özet:

 


Objective. This study aimed to evaluate
concurrently detected second primary malignancy in the patients who underwent
surgery for papillary thyroid carcinoma. Methods.
In this study, we retrospectively analyzed the files of the patients who
underwent surgery for papillary thyroid carcinoma between 2000-2017. A total number of 601 patients with papillary
thyroid carcinoma were evaluated. Among these patients, 48 patients were
found to have secondary primary tumors. Preoperative and postoperative
laboratory examination findings of the patients were retrospectively recorded. Results. Among 601 patients with
papillary thyroid cancer evaluated with respect to radiation exposure, the
second primary tumor with breast cancer was found to be the most common tumor.
Renal cell carcinoma, malignant melanoma and stomach cancer were found to be
more frequent when evaluated regardless of radiation effect. Furthermore, when
molecular genetic results were evaluated, BRAF mutation rate was found to be
more frequent than in other secondary tumors, especially in patients with renal
cell carcinoma. Conclusions.
The importance of epidemiological and experimental studies of multiple cancers
is obvious. Although it is known that the impact of radiation is considerable
among the ones with concurrence of breast cancer and papillary thyroid
carcinoma, we suggest that further studies on common molecular genetic
characteristics and development of targeted treatment for detected molecules
are required in the patients with renal cell carcinoma in whom papillary
thyroid carcinoma is diagnosed regardless of radiation effect. 



.

Makale detayları

Synchronous and antecedent malignancies in patients with papillary thyroid carcinoma

Yazarlar: Mehmet ÇELİK | Buket YILMAZ BÜLBÜL | Semra AYTÜRK | Ahmet KÜÇÜKARDA | Ebru TAŞTEKİN | Nuray CAN | Funda ÜSTÜN | Yavuz Atakan SEZER | Sibel GÜLDİKEN

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2018 Vol.4 Issue 3, pp.215-219

Belge Tipi: Makale

Yayın Tarihi: 7/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000663195

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.360833

Sayı

Yazarlar:

Mehmet ÇELİK | Buket YILMAZ BÜLBÜL | Semra AYTÜRK | Ahmet KÜÇÜKARDA | Ebru TAŞTEKİN | Nuray CAN | Funda ÜSTÜN | Yavuz Atakan SEZER | Sibel GÜLDİKEN

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2018 Vol.4 Issue 3, pp.215-219

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000663195

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.360833