Neuroprotective Effect of Farnesol Against Rotenone Induced Parkinson’s Disease in Drosophila  Melanogaster

Praveen Thaggikuppe Krishnamurthy

Makale detayları

Neuroprotective Effect of Farnesol Against Rotenone Induced Parkinson’s Disease in Drosophila Melanogaster

Yazarlar:

Praveen Thaggikuppe Krishnamurthy

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.15-21

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284498

pISSN:

2458-8806

Anahtar kelimeler:

Özet:

 The current study aimed to investigate the neuroprotective effects of farnesol on rotenone-induced neurotoxicity in Drosophila melanogaster. Neurotoxicity was induced in Drosophila melanogaster by administering 500 μmol of rotenone and then the flies were administered either 300 μmol or 600 μmol of farnesol in the diet for the duration of the experiment. The study measured the effect of farnesol on longevity through a survival rate study, and locomotor function through a negative geotaxis assay. In addition, the study also estimated in vivo antioxidant parameters to determine the impact of farnesol on oxidative stress. The results showed that farnesol improved both longevity and locomotor function in the flies treated with 300 μmol or 600 μmol of test compound compared to control. The antioxidant studies also demonstrated that farnesol enhanced the catalase and superoxide dismutase activity and decreased lipid peroxidation. Based on these findings, it is concluded that farnesol might exhibit a significant neuroprotective effect against Parkinsons disease.

 The current study aimed to investigate the neuroprotective effects of farnesol on rotenone-induced neurotoxicity in Drosophila melanogaster. Neurotoxicity was induced in Drosophila melanogaster by administering 500 μmol of rotenone and then the flies were administered either 300 μmol or 600 μmol of farnesol in the diet for the duration of the experiment. The study measured the effect of farnesol on longevity through a survival rate study, and locomotor function through a negative geotaxis assay. In addition, the study also estimated in vivo antioxidant parameters to determine the impact of farnesol on oxidative stress. The results showed that farnesol improved both longevity and locomotor function in the flies treated with 300 μmol or 600 μmol of test compound compared to control. The antioxidant studies also demonstrated that farnesol enhanced the catalase and superoxide dismutase activity and decreased lipid peroxidation. Based on these findings, it is concluded that farnesol might exhibit a significant neuroprotective effect against Parkinsons disease.

 The current study aimed to investigate the neuroprotective effects of farnesol on rotenone-induced neurotoxicity in Drosophila melanogaster. Neurotoxicity was induced in Drosophila melanogaster by administering 500 μmol of rotenone and then the flies were administered either 300 μmol or 600 μmol of farnesol in the diet for the duration of the experiment. The study measured the effect of farnesol on longevity through a survival rate study, and locomotor function through a negative geotaxis assay. In addition, the study also estimated in vivo antioxidant parameters to determine the impact of farnesol on oxidative stress. The results showed that farnesol improved both longevity and locomotor function in the flies treated with 300 μmol or 600 μmol of test compound compared to control. The antioxidant studies also demonstrated that farnesol enhanced the catalase and superoxide dismutase activity and decreased lipid peroxidation. Based on these findings, it is concluded that farnesol might exhibit a significant neuroprotective effect against Parkinsons disease.

 The current study aimed to investigate the neuroprotective effects of farnesol on rotenone-induced neurotoxicity in Drosophila melanogaster. Neurotoxicity was induced in Drosophila melanogaster by administering 500 μmol of rotenone and then the flies were administered either 300 μmol or 600 μmol of farnesol in the diet for the duration of the experiment. The study measured the effect of farnesol on longevity through a survival rate study, and locomotor function through a negative geotaxis assay. In addition, the study also estimated in vivo antioxidant parameters to determine the impact of farnesol on oxidative stress. The results showed that farnesol improved both longevity and locomotor function in the flies treated with 300 μmol or 600 μmol of test compound compared to control. The antioxidant studies also demonstrated that farnesol enhanced the catalase and superoxide dismutase activity and decreased lipid peroxidation. Based on these findings, it is concluded that farnesol might exhibit a significant neuroprotective effect against Parkinsons disease.

Makale detayları

Neuroprotective Effect of Farnesol Against Rotenone Induced Parkinson’s Disease in Drosophila Melanogaster

Yazarlar:

Praveen Thaggikuppe Krishnamurthy

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.15-21

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284498

pISSN:

2458-8806

Farnesol

Drosophila melanogaster

negative geotaxis

survival rate

antioxidants

Farnesol

Drosophila melanogaster

negative geotaxis

survival rate

antioxidants

Sayı

Makale detayları

Yazarlar: Praveen Thaggikuppe Krishnamurthy

Yayıncı: Hacettepe University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences

Dergi: Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.15-21

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001284498

pISSN: 2458-8806

Sayı

Yazarlar:

Praveen Thaggikuppe Krishnamurthy

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.15-21

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284498

pISSN:

2458-8806