The Effects of Cimetidine and Ranitidine on Kidney Cortex of Mus musculus albinus

Kadriye AKGÜN DAR

Makale detayları

The Effects of Cimetidine and Ranitidine on Kidney Cortex of Mus musculus albinus

Yazarlar:

Kadriye AKGÜN DAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Zoology 2002 Vol.26 Issue 2, pp.205-211

Belge Tipi:

Makale

Yayın Tarihi:

1/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000778583

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179

Anahtar kelimeler:

Özet:

 

In this study, 4.3 µg/g cimetidine and 17 µg/g ranitidine were orally given to mice for two months. The effects of cimetidine and ranitidine on kidney cortical tissue were examined at light microscopical level. In both groups, it was detected that the tubules were separated by their lumen containing darkly stained remnant material. Vacuolization, destruction of apical membrane and decreased PAS positive reaction were observed in the apical membrane of proximal tubule epithelial cells. The nuclei of proximal and distal tubule cells were cylindrical. More excessively in the ranitidine treated group, widening of the tubule lumens and limited proximal tubule lobulation were observed. On the other hand, invagination of some distal tubules towards the lumen was detected. In conclusion, both drugs were found to be effective on kidney cortical tissue.

 

In this study, 4.3 µg/g cimetidine and 17 µg/g ranitidine were orally given to mice for two months. The effects of cimetidine and ranitidine on kidney cortical tissue were examined at light microscopical level. In both groups, it was detected that the tubules were separated by their lumen containing darkly stained remnant material. Vacuolization, destruction of apical membrane and decreased PAS positive reaction were observed in the apical membrane of proximal tubule epithelial cells. The nuclei of proximal and distal tubule cells were cylindrical. More excessively in the ranitidine treated group, widening of the tubule lumens and limited proximal tubule lobulation were observed. On the other hand, invagination of some distal tubules towards the lumen was detected. In conclusion, both drugs were found to be effective on kidney cortical tissue.

Makale detayları

The Effects of Cimetidine and Ranitidine on Kidney Cortex of Mus musculus albinus

Yazarlar:

Kadriye AKGÜN DAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Zoology 2002 Vol.26 Issue 2, pp.205-211

Belge Tipi:

Makale

Yayın Tarihi:

1/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000778583

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179

Cimetidine

ranitidine

kidney

mouse.

Sayı

Makale detayları

The Effects of Cimetidine and Ranitidine on Kidney Cortex of Mus musculus albinus

Yazarlar: Kadriye AKGÜN DAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Zoology 2002 Vol.26 Issue 2, pp.205-211

Belge Tipi: Makale

Yayın Tarihi: 1/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000778583

Sıklık: İki Aylık

eISSN: 1303-6114

pISSN: 1300-0179

Cimetidine

ranitidine

kidney

mouse.

Sayı

Yazarlar:

Kadriye AKGÜN DAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Zoology 2002 Vol.26 Issue 2, pp.205-211

Belge Tipi:

Makale

Yayın Tarihi:

1/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000778583

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179