İnsan Papilloma Virüsü (HPV) ve Aşılarının Kullanımı Sonrası Toplumsal Etkileri

Aybüke OKAY; Semra SOYDAM AYDIN; Levent AKIN

Makale detayları

İnsan Papilloma Virüsü (HPV) ve Aşılarının Kullanımı Sonrası Toplumsal Etkileri

Yazarlar:

Aybüke OKAY | Semra SOYDAM AYDIN | Levent AKIN

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Hastalıklar

Dergi:

Abant Medical Journal 2022 Vol.11 Issue 1, pp.143-151

Belge Tipi:

Makale

Yayın Tarihi:

4/2022

Belge Dili:

Türkçe

Document ID (Org No.):

2000435582

Sıklık:

Üç Yıllık

eISSN:

2147-1800

pISSN:

1305-4392

Özet:

 


Human Papilloma Virus (IPV/HPV) is a DNA virus belonging to the papillomavirus family that infects basal epithelial cells on skin and mucosal surfaces. HPV is the cause of cancers of the anus, penis, vulva, vagina and oropharynx as well as cervical (cervix) cancer. It has been understood that HPV virus can be seen at almost any age, regardless of sociocultural and economic parameters. In addition, although there are no symptoms for a long time in infected people, the life cycle of the virus in the body can continue and may cause cancer development in the long term. It has been proven that generating neutralizing antibodies against HPV capsid proteins can be achieved through an effective prophylactic vaccine production strategy against infection. There are three types of HPV vaccines: bivalent (2vHPV), quadrivalent (4vHPV), and nanovalent (9vHPV). The bivalent HPV vaccine (2vHPV) contains VLPs 16 and 18, the most oncogenic HPV types responsible for approximately 71% of cervical cancers. Quadrivalan HPV (4vHPV) includes VLPs 16 and 18, along with VLPs 6 and 11, which are responsible for approximately 90% of genital warts. In addition to the quadrivalent HPV (4vHPV) content, the nanonovalan (9vHPV) vaccines also contain the HPV types 31, 33, 45, 52, 58 VLPs that are frequently detected in cervical cancer. Prophylactic HPV vaccines are known to be immunogenic and effective against targeted types of HPV infections and type-specific genital lesions, including high-grade cervical intraepithelial neoplasia (CIN), when administered prior to HPV infection. In this review study, the basic mechanism of the HPV virus, the types of vaccines administered, its global use, and its social effects after vaccination are discussed.

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Makale detayları

İnsan Papilloma Virüsü (HPV) ve Aşılarının Kullanımı Sonrası Toplumsal Etkileri

Yazarlar: Aybüke OKAY | Semra SOYDAM AYDIN | Levent AKIN

Yayıncı: Bolu Abant Izzet Baysal University

Ana Başlıklar: Hastalıklar

Dergi: Abant Medical Journal 2022 Vol.11 Issue 1, pp.143-151

Belge Tipi: Makale

Yayın Tarihi: 4/2022

Belge Dili: Türkçe

Document ID (Org No.): 2000435582

Sıklık: Üç Yıllık

eISSN: 2147-1800

pISSN: 1305-4392

Sayı

Yazarlar:

Aybüke OKAY | Semra SOYDAM AYDIN | Levent AKIN

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Hastalıklar

Dergi:

Abant Medical Journal 2022 Vol.11 Issue 1, pp.143-151

Belge Tipi:

Makale

Yayın Tarihi:

4/2022

Belge Dili:

Türkçe

Document ID (Org No.):

2000435582

Sıklık:

Üç Yıllık

eISSN:

2147-1800

pISSN:

1305-4392