Association of thrombocytopenia on secondary infection and mortality in pediatric intensive care unit patients receiving continuous renal replacement therapy

Gültaç Evren

Makale detayları

Association of thrombocytopenia on secondary infection and mortality in pediatric intensive care unit patients receiving continuous renal replacement therapy

Yazarlar:

Gültaç Evren

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Yoğun Bakım

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.303-307

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343112

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: Continuous renal replacement therapy CRRT is a widely used treatment modality in pediatric patients. We aimed to evaluate the susceptibility of thrombocytopenia to secondary infection and mortality during intensive care unit admission and the initiation of CRRT in patients admitted to the pediatric intensive care unit. Methods: We conducted a retrospective study of patients in a tertiary pediatric intensive care unit who underwent CRRT between February 2021 and July 2024. The study included 34 patients who underwent CRRT. Results: The study population consisted of patients with a median age of 26 months and 58.8 were male. At pediatric intensive care units PICU admission, 10 29.4 patients had thrombocytopenia, whereas 15 44.1 had thrombocytopenia at CRRT initiation. Patients with thrombocytopenia at the start of CRRT had a greater risk of mortality. Mortality approached significance in patients with thrombocytopenia at PICU admission. The risk of infection was significantly increased in patients with thrombocytopenia at the start of CRRT according to univariate and multivariate regression analyses p0.01. Conclusion: The detection of thrombocytopenia at the beginning of CRRT is associated with a higher secondary infection rate and mortality during pediatric intensive care hospitalization. CRRT and thrombocytopenia negatively impact immune function, and further prospective studies are needed to assess their association with subsequent infection risk.

 Aims: Continuous renal replacement therapy CRRT is a widely used treatment modality in pediatric patients. We aimed to evaluate the susceptibility of thrombocytopenia to secondary infection and mortality during intensive care unit admission and the initiation of CRRT in patients admitted to the pediatric intensive care unit. Methods: We conducted a retrospective study of patients in a tertiary pediatric intensive care unit who underwent CRRT between February 2021 and July 2024. The study included 34 patients who underwent CRRT. Results: The study population consisted of patients with a median age of 26 months and 58.8 were male. At pediatric intensive care units PICU admission, 10 29.4 patients had thrombocytopenia, whereas 15 44.1 had thrombocytopenia at CRRT initiation. Patients with thrombocytopenia at the start of CRRT had a greater risk of mortality. Mortality approached significance in patients with thrombocytopenia at PICU admission. The risk of infection was significantly increased in patients with thrombocytopenia at the start of CRRT according to univariate and multivariate regression analyses p0.01. Conclusion: The detection of thrombocytopenia at the beginning of CRRT is associated with a higher secondary infection rate and mortality during pediatric intensive care hospitalization. CRRT and thrombocytopenia negatively impact immune function, and further prospective studies are needed to assess their association with subsequent infection risk.

 Aims: Continuous renal replacement therapy CRRT is a widely used treatment modality in pediatric patients. We aimed to evaluate the susceptibility of thrombocytopenia to secondary infection and mortality during intensive care unit admission and the initiation of CRRT in patients admitted to the pediatric intensive care unit. Methods: We conducted a retrospective study of patients in a tertiary pediatric intensive care unit who underwent CRRT between February 2021 and July 2024. The study included 34 patients who underwent CRRT. Results: The study population consisted of patients with a median age of 26 months and 58.8 were male. At pediatric intensive care units PICU admission, 10 29.4 patients had thrombocytopenia, whereas 15 44.1 had thrombocytopenia at CRRT initiation. Patients with thrombocytopenia at the start of CRRT had a greater risk of mortality. Mortality approached significance in patients with thrombocytopenia at PICU admission. The risk of infection was significantly increased in patients with thrombocytopenia at the start of CRRT according to univariate and multivariate regression analyses p0.01. Conclusion: The detection of thrombocytopenia at the beginning of CRRT is associated with a higher secondary infection rate and mortality during pediatric intensive care hospitalization. CRRT and thrombocytopenia negatively impact immune function, and further prospective studies are needed to assess their association with subsequent infection risk.

 Amaç Sürekli renal replasman tedavisi SRRT, pediatrik hastalarda yaygın olarak kullanılan bir tedavi yöntemidir. Yoğun bakım ünitesine kabul sırasında ve pediatrik yoğun bakım ünitesine kabul edilen hastalarda CRRTnin başlatılması sırasında trombositopeninin sekonder enfeksiyona ve mortaliteye duyarlılığını değerlendirmeyi amaçladık. Yöntem Şubat 2021 ile Temmuz 2024 arasında SRRT uygulanan üçüncü basamak Pediatrik Yoğun Bakım Ünitesindeki hastalarla ilgili retrospektif bir çalışma yürüttük. Çalışmaya SRRT uygulanan 34 hasta dahil edildi. Bulgular Çalışma popülasyonu, medyan yaşı 26 ay olan hastalardan oluşuyordu ve 58,8i erkekti. PICUya kabulde 10 29,4 hastada trombositopeni vardı, buna karşın 15 44,1 hastada CRRT başlangıcında trombositopeni vardı. CRRT başlangıcında trombositopenisi olan hastalarda mortalite riski daha yüksekti. PICUya kabul edilen trombositopenili hastalarda mortalite önemli düzeye yaklaştı. Tek değişkenli ve çok değişkenli regresyon analizlerine göre SRRT başlangıcında trombositopenili hastalarda enfeksiyon riski önemli ölçüde artmıştı p  0,01. Sonuç SRRT başlangıcında trombositopeninin saptanması, pediatrik yoğun bakım hastanesinde yatış sırasında daha yüksek sekonder enfeksiyon oranı ve mortalite ile ilişkilidir. SRRT ve trombositopeni bağışıklık fonksiyonunu olumsuz etkiler ve bunların sonraki enfeksiyon riski ile ilişkisini değerlendirmek için daha fazla prospektif çalışmaya ihtiyaç vardır.

Makale detayları

Association of thrombocytopenia on secondary infection and mortality in pediatric intensive care unit patients receiving continuous renal replacement therapy

Yazarlar:

Gültaç Evren

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Yoğun Bakım

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.303-307

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343112

pISSN:

2636-8579

Continuous renal replacement therapy

pediatric intensive care

secondary infection

thrombocytopenia

mortalitySürekli renal replasman tedavisi

pediatrik yoğun bakım

trombositopeni

sekonder enfeksiyon

mortalite

Sayı

Makale detayları

Yazarlar: Gültaç Evren

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Yoğun Bakım

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.303-307

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343112

pISSN: 2636-8579

Sayı

Yazarlar:

Gültaç Evren

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Yoğun Bakım

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.303-307

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343112

pISSN:

2636-8579