Increased Expression of the Actin-Related Protein 2 (ACTR2) Gene in Pterygium

Soran Abdullah; Kübra Şahin; Ömer Ateş; Nihan Bozkurt; Sadegul Tuncer Savkin; Helin Deniz Demir

Makale detayları

Increased Expression of the Actin-Related Protein 2 (ACTR2) Gene in Pterygium

Yazarlar:

Soran Abdullah | Kübra Şahin | Ömer Ateş | Nihan Bozkurt | Sadegul Tuncer Savkin | Helin Deniz Demir

Yayıncı:

Marmara University

Ana Başlıklar:

Medical Genetics (Excl. Cancer Genetics)

Dergi:

Clinical and Experimental Health Sciences Vol.14 Issue 3, pp.631-635

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328359

pISSN:

2459-1459

Anahtar kelimeler:

Özet:

 Objective: Pterygium is a fibrovascular conjunctival degeneration whose pathogenesis remains unclear, although many risk factors have been identified. In our study, we purposed to find the level of Actin Related Protein 2 ACTR2 gene expression in healthy conjunctiva tissues and pterygium to increase our understanding of the pathogenesis of pterygium. Methods: The study included 27 patients who underwent pterygium excision. ACTR2 mRNA expression level in healthy conjunctiva tissues and pterygium were determined by the Real-Time PCR method. Results: According to the results we obtained, ACTR2 gene expression was increased in 74 2027 of our cases, while ACTR2 gene expression was decreased in 26 727. ACTR2 mRNA expression was detected to be remarkably higher in pterygium in proportion to conjunctiva tissue p.05. Conclusion: Our findings show that the ACTR2 gene and cell migration mechanism may play a role in the development of pterygium. However, supplementary research is requirement to determine the efficacy of the ACTR2 gene in pterygium disease and to better understand the relationship of the ACTR2 gene with pterygium.

 Objective: Pterygium is a fibrovascular conjunctival degeneration whose pathogenesis remains unclear, although many risk factors have been identified. In our study, we purposed to find the level of Actin Related Protein 2 ACTR2 gene expression in healthy conjunctiva tissues and pterygium to increase our understanding of the pathogenesis of pterygium. Methods: The study included 27 patients who underwent pterygium excision. ACTR2 mRNA expression level in healthy conjunctiva tissues and pterygium were determined by the Real-Time PCR method. Results: According to the results we obtained, ACTR2 gene expression was increased in 74 2027 of our cases, while ACTR2 gene expression was decreased in 26 727. ACTR2 mRNA expression was detected to be remarkably higher in pterygium in proportion to conjunctiva tissue p.05. Conclusion: Our findings show that the ACTR2 gene and cell migration mechanism may play a role in the development of pterygium. However, supplementary research is requirement to determine the efficacy of the ACTR2 gene in pterygium disease and to better understand the relationship of the ACTR2 gene with pterygium.

 Objective: Pterygium is a fibrovascular conjunctival degeneration whose pathogenesis remains unclear, although many risk factors have been identified. In our study, we purposed to find the level of Actin Related Protein 2 ACTR2 gene expression in healthy conjunctiva tissues and pterygium to increase our understanding of the pathogenesis of pterygium. Methods: The study included 27 patients who underwent pterygium excision. ACTR2 mRNA expression level in healthy conjunctiva tissues and pterygium were determined by the Real-Time PCR method. Results: According to the results we obtained, ACTR2 gene expression was increased in 74 2027 of our cases, while ACTR2 gene expression was decreased in 26 727. ACTR2 mRNA expression was detected to be remarkably higher in pterygium in proportion to conjunctiva tissue p.05. Conclusion: Our findings show that the ACTR2 gene and cell migration mechanism may play a role in the development of pterygium. However, supplementary research is requirement to determine the efficacy of the ACTR2 gene in pterygium disease and to better understand the relationship of the ACTR2 gene with pterygium.

 Objective: Pterygium is a fibrovascular conjunctival degeneration whose pathogenesis remains unclear, although many risk factors have been identified. In our study, we purposed to find the level of Actin Related Protein 2 ACTR2 gene expression in healthy conjunctiva tissues and pterygium to increase our understanding of the pathogenesis of pterygium. Methods: The study included 27 patients who underwent pterygium excision. ACTR2 mRNA expression level in healthy conjunctiva tissues and pterygium were determined by the Real-Time PCR method. Results: According to the results we obtained, ACTR2 gene expression was increased in 74 2027 of our cases, while ACTR2 gene expression was decreased in 26 727. ACTR2 mRNA expression was detected to be remarkably higher in pterygium in proportion to conjunctiva tissue p.05. Conclusion: Our findings show that the ACTR2 gene and cell migration mechanism may play a role in the development of pterygium. However, supplementary research is requirement to determine the efficacy of the ACTR2 gene in pterygium disease and to better understand the relationship of the ACTR2 gene with pterygium.

Makale detayları

Increased Expression of the Actin-Related Protein 2 (ACTR2) Gene in Pterygium

Yazarlar:

Soran Abdullah | Kübra Şahin | Ömer Ateş | Nihan Bozkurt | Sadegul Tuncer Savkin | Helin Deniz Demir

Yayıncı:

Marmara University

Ana Başlıklar:

Medical Genetics (Excl. Cancer Genetics)

Dergi:

Clinical and Experimental Health Sciences Vol.14 Issue 3, pp.631-635

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328359

pISSN:

2459-1459

Actin cytoskeleton

ACTR2

Cell migration

Expression

PterygiumActin cytoskeleton

ACTR2

Cell migration

Expression

Pterygium

Sayı

Makale detayları

Yazarlar: Soran Abdullah | Kübra Şahin | Ömer Ateş | Nihan Bozkurt | Sadegul Tuncer Savkin | Helin Deniz Demir

Yayıncı: Marmara University

Ana Başlıklar: Medical Genetics (Excl. Cancer Genetics)

Dergi: Clinical and Experimental Health Sciences Vol.14 Issue 3, pp.631-635

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001328359

pISSN: 2459-1459

Sayı

Yazarlar:

Soran Abdullah | Kübra Şahin | Ömer Ateş | Nihan Bozkurt | Sadegul Tuncer Savkin | Helin Deniz Demir

Yayıncı:

Marmara University

Ana Başlıklar:

Medical Genetics (Excl. Cancer Genetics)

Dergi:

Clinical and Experimental Health Sciences Vol.14 Issue 3, pp.631-635

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328359

pISSN:

2459-1459