The Effect of Topical Atorvastatin on Viability of Random Pattern Skin Flaps, Experimental Study

Bilgen CAN; Okan Özgür ÖZTURAN; Meltem ORAL; Sadi BENER

doi:https://doi.org/10.20515/otd.858659

Makale detayları

The Effect of Topical Atorvastatin on Viability of Random Pattern Skin Flaps, Experimental Study

Yazarlar:

Bilgen CAN | Okan Özgür ÖZTURAN | Meltem ORAL | Sadi BENER

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Osmangazi Journal of Medicine 2021 Vol.43 Issue 4, pp.396-402

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000554924

Sıklık:

İki Aylık

eISSN:

2587-1579

pISSN:

1305-4953

DOI:

https://doi.org/10.20515/otd.858659

Özet:

 


Augmentation of viability of random pattern flaps has long been an issue in plastic surgery. Up to date no agents were clinically introduced. Atorvastatins are used clinically for lipid lowering. They are also effective on flap survival with their angiogenic, anti-inflammatory, antioxidant effects with systeic administration. In this study, Atorvastatin is used topically for flap survival alleviation in Mc Farlane flap in rats.  Wibstar albino type  20 male rats weighing about 180-230 grams were classified as experiment and control group. Results were evaluated by flap necrosis ratios, lymphocyte cells, neutrophile cells, capillary  and granulation tissue density on the 7th postoperative day.. Flap necrosis areas were evaluated with Sasaki's paratemplate method. Tissue biopsies of 1x1 cm at the transition zone between necrotic and healthy tissue, were embedded in parafin blocks after fixation in 10% formalin. Biopsies were sliced by 4 micrometer thickness with a microtome. Cross sections were painted with hematoxylene eosin and evaluated with a light microscope. Whitneyy U test was performed for clinical and histopathological evaluation of  groups (p<0,05). Flap viability was alleviated. Average necrosis ratios on flaps were 32.1% in the control group and 14.17% in experimental group.  Capillary tissue and neutrophile cell density were found to be higher in atorvastatin group. . Granulation tissue and lymphocyte cell density were not found significantly higher.. Atorvastatins, when applied topically, are effective on flap survival. Further studies should be carried out for human clinical use.

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Makale detayları

The Effect of Topical Atorvastatin on Viability of Random Pattern Skin Flaps, Experimental Study

Yazarlar: Bilgen CAN | Okan Özgür ÖZTURAN | Meltem ORAL | Sadi BENER

Yayıncı: Eskişehir Osmangazi University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Osmangazi Journal of Medicine 2021 Vol.43 Issue 4, pp.396-402

Belge Tipi: Makale

Yayın Tarihi: 5/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000554924

Sıklık: İki Aylık

eISSN: 2587-1579

pISSN: 1305-4953

DOI: https://doi.org/10.20515/otd.858659

Sayı

Yazarlar:

Bilgen CAN | Okan Özgür ÖZTURAN | Meltem ORAL | Sadi BENER

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Osmangazi Journal of Medicine 2021 Vol.43 Issue 4, pp.396-402

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000554924

Sıklık:

İki Aylık

eISSN:

2587-1579

pISSN:

1305-4953

DOI:

https://doi.org/10.20515/otd.858659