Why Vitamin B12 Levels Are High In Children With Cerebral Palsy ?

Hilal Aydın; İbrahim Bucak; Sevda Taştan

Makale detayları

Why Vitamin B12 Levels Are High In Children With Cerebral Palsy ?

Yazarlar:

Hilal Aydın | İbrahim Bucak | Sevda Taştan

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Hipokrat Tıp Dergisi Vol.3 Issue 2, pp.1-8

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296206

pISSN:

2791-9935

Anahtar kelimeler:

Özet:

 Background: The purpose of the present study was therefore to evaluate vitamin B12 levels in cases under follow-up with diagnoses of cerebral palsy CP compared to healthy controls. Methods: Fifty-three cases presenting to the Adiyaman University Education and Research Hospital pediatric neurology clinic diagnosed with CP were included retrospectively in this study. Sixty-three cases of similar age and weight presenting to the child health and diseases clinic in the control group. Demographic data, laboratory results hemoglobin Hb, hematocrit Hct, mean corpuscular volume MCV, platelet plt, folate, ferritin, vitamin B12, and vitamin 25 OH D findings were recorded from the patient files. Results: Complete blood count parameters Hb p0.004, hct p0.000, mcv p0.000, and plt p0.001, vitamin B12 p0.031 and vitamin D levels p0.002 were significantly lower in the study group than in the control group. Conclusions: In contrast to previous studies in the literature, vitamin B12 levels were higher in patients with CP than in the healthy controls. The fact that the underlying pathophysiological mechanism is not fully understood clearly derives from the limited investigation of the subject in the literature to date.

 Background: The purpose of the present study was therefore to evaluate vitamin B12 levels in cases under follow-up with diagnoses of cerebral palsy CP compared to healthy controls. Methods: Fifty-three cases presenting to the Adiyaman University Education and Research Hospital pediatric neurology clinic diagnosed with CP were included retrospectively in this study. Sixty-three cases of similar age and weight presenting to the child health and diseases clinic in the control group. Demographic data, laboratory results hemoglobin Hb, hematocrit Hct, mean corpuscular volume MCV, platelet plt, folate, ferritin, vitamin B12, and vitamin 25 OH D findings were recorded from the patient files. Results: Complete blood count parameters Hb p0.004, hct p0.000, mcv p0.000, and plt p0.001, vitamin B12 p0.031 and vitamin D levels p0.002 were significantly lower in the study group than in the control group. Conclusions: In contrast to previous studies in the literature, vitamin B12 levels were higher in patients with CP than in the healthy controls. The fact that the underlying pathophysiological mechanism is not fully understood clearly derives from the limited investigation of the subject in the literature to date.

 Background: The purpose of the present study was therefore to evaluate vitamin B12 levels in cases under follow-up with diagnoses of cerebral palsy CP compared to healthy controls. Methods: Fifty-three cases presenting to the Adiyaman University Education and Research Hospital pediatric neurology clinic diagnosed with CP were included retrospectively in this study. Sixty-three cases of similar age and weight presenting to the child health and diseases clinic in the control group. Demographic data, laboratory results hemoglobin Hb, hematocrit Hct, mean corpuscular volume MCV, platelet plt, folate, ferritin, vitamin B12, and vitamin 25 OH D findings were recorded from the patient files. Results: Complete blood count parameters Hb p0.004, hct p0.000, mcv p0.000, and plt p0.001, vitamin B12 p0.031 and vitamin D levels p0.002 were significantly lower in the study group than in the control group. Conclusions: In contrast to previous studies in the literature, vitamin B12 levels were higher in patients with CP than in the healthy controls. The fact that the underlying pathophysiological mechanism is not fully understood clearly derives from the limited investigation of the subject in the literature to date.

 Amaç: Bu çalışmanın amacı serebral palsi tanısı ile izlenen olguların sağlıklı kontrollere göre vitamin B12 düzeylerinin değerlendirilmesi hedeflenmiştir. Metod: Çalışmaya Adıyaman Üniversitesi Eğitim ve Araştırma Hastanesi çocuk nöroloji polikliniğine başvuran ve serebral palsi tanısı konulan 53 olgu retrospektif olarak dahil edildi. Kontrol grubuna aynı dönemde çocuk sağlığı ve hastalıkları polikliniğine başvuran, sağlıklı çocuk muayenesi girilen ve yaş ve kilo açısından benzer 63 olgu alındı. Hasta dosyalarından demografik veriler, laboratuvar sonuçları hemoglobin Hb, hematokrit Hct, ortalama korpüsküler hacim MCV, platelet plt, folat, ferritin, vitamin B12, 25 OH D vitamini, kranial görüntülemeleri ve elektroensefalografi EEG bulguları kayıt altına alındı. Bulgular: Çalışma ve kontrol grubunda hemogram parametreleri Hb p0.004, Hct p0.000, MCV p0.000, plt p0.001, vitamin B12 p0.031 ve vitamin D p0.002 düzeyleri arasında istatiksel olarak anlamlı düşük saptandı. Sonuç: Çalısmamızda literaturde belirtilen çalışmaların aksine SPli hastalarda sağlıklı kontrollere göre vitamin B12 düzeyinin daha yüksek olduğu saptanmıştır. Bu durumun altta yatan pato-fizyolojik mekanizması tam olarak bilinmemesini konunun literatürde sınırlı olarak çalışılmasından kaynaklandığı ortadadır.

Makale detayları

Why Vitamin B12 Levels Are High In Children With Cerebral Palsy ?

Yazarlar:

Hilal Aydın | İbrahim Bucak | Sevda Taştan

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Hipokrat Tıp Dergisi Vol.3 Issue 2, pp.1-8

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296206

pISSN:

2791-9935

Cerebral palsy

vitamin B12

vitamin D

folateCerebral palsy

vitamin B12

vitamin D

folate

Sayı

Makale detayları

Yazarlar: Hilal Aydın | İbrahim Bucak | Sevda Taştan

Yayıncı: Bandirma Onyedi Eylul University

Ana Başlıklar: Çocuk Sağlığı ve Hastalıkları

Dergi: Hipokrat Tıp Dergisi Vol.3 Issue 2, pp.1-8

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001296206

pISSN: 2791-9935

Sayı

Yazarlar:

Hilal Aydın | İbrahim Bucak | Sevda Taştan

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Hipokrat Tıp Dergisi Vol.3 Issue 2, pp.1-8

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296206

pISSN:

2791-9935