Nepeta humilis Bentham: First evaluation of phenolic profile and radical scavenging potential

Alper Gökbulut

Makale detayları

Nepeta humilis Bentham: First evaluation of phenolic profile and radical scavenging potential

Yazarlar:

Alper Gökbulut

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.901-907

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348014

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In traditional medicine, Lamiaceae plants are widely used as a cure for various health problems. Nepeta humilis is one of the Lamiaceae plants of Iranian-Turkish district growing naturally in the South East Anatolia. The present study was designed to investigate the radical scavenging activity and total phenolic content of Nepeta humilis as well as to determine the phenolic constituents of the extracts of flowers, leaves and roots using a previously validated RP-HPLC-DAD method for the first time. The total phenolic contents of flowers, leaves and roots were found as 123.18  1.01, 66.20  0.49 and 54.77  1.23 mg GAEg extract, respectively. In accordance with the higher total phenolic content, flower extract of the plant displayed more radical scavenging activity with both assays. HPLC results revealed that rosmarinic acid was detected as one of the main compounds in all the investigated parts of the plant, especially in the flowers 0.397  0.01 g100g dry weight. Also, chlorogenic acid, luteolin and apigenin were found in particular amount in the flower extract. Nepeta humilis is rich in phenolic compounds and can be evaluated as a promising antioxidant source.

 In traditional medicine, Lamiaceae plants are widely used as a cure for various health problems. Nepeta humilis is one of the Lamiaceae plants of Iranian-Turkish district growing naturally in the South East Anatolia. The present study was designed to investigate the radical scavenging activity and total phenolic content of Nepeta humilis as well as to determine the phenolic constituents of the extracts of flowers, leaves and roots using a previously validated RP-HPLC-DAD method for the first time. The total phenolic contents of flowers, leaves and roots were found as 123.18  1.01, 66.20  0.49 and 54.77  1.23 mg GAEg extract, respectively. In accordance with the higher total phenolic content, flower extract of the plant displayed more radical scavenging activity with both assays. HPLC results revealed that rosmarinic acid was detected as one of the main compounds in all the investigated parts of the plant, especially in the flowers 0.397  0.01 g100g dry weight. Also, chlorogenic acid, luteolin and apigenin were found in particular amount in the flower extract. Nepeta humilis is rich in phenolic compounds and can be evaluated as a promising antioxidant source.

 In traditional medicine, Lamiaceae plants are widely used as a cure for various health problems. Nepeta humilis is one of the Lamiaceae plants of Iranian-Turkish district growing naturally in the South East Anatolia. The present study was designed to investigate the radical scavenging activity and total phenolic content of Nepeta humilis as well as to determine the phenolic constituents of the extracts of flowers, leaves and roots using a previously validated RP-HPLC-DAD method for the first time. The total phenolic contents of flowers, leaves and roots were found as 123.18  1.01, 66.20  0.49 and 54.77  1.23 mg GAEg extract, respectively. In accordance with the higher total phenolic content, flower extract of the plant displayed more radical scavenging activity with both assays. HPLC results revealed that rosmarinic acid was detected as one of the main compounds in all the investigated parts of the plant, especially in the flowers 0.397  0.01 g100g dry weight. Also, chlorogenic acid, luteolin and apigenin were found in particular amount in the flower extract. Nepeta humilis is rich in phenolic compounds and can be evaluated as a promising antioxidant source.

 In traditional medicine, Lamiaceae plants are widely used as a cure for various health problems. Nepeta humilis is one of the Lamiaceae plants of Iranian-Turkish district growing naturally in the South East Anatolia. The present study was designed to investigate the radical scavenging activity and total phenolic content of Nepeta humilis as well as to determine the phenolic constituents of the extracts of flowers, leaves and roots using a previously validated RP-HPLC-DAD method for the first time. The total phenolic contents of flowers, leaves and roots were found as 123.18  1.01, 66.20  0.49 and 54.77  1.23 mg GAEg extract, respectively. In accordance with the higher total phenolic content, flower extract of the plant displayed more radical scavenging activity with both assays. HPLC results revealed that rosmarinic acid was detected as one of the main compounds in all the investigated parts of the plant, especially in the flowers 0.397  0.01 g100g dry weight. Also, chlorogenic acid, luteolin and apigenin were found in particular amount in the flower extract. Nepeta humilis is rich in phenolic compounds and can be evaluated as a promising antioxidant source.

Makale detayları

Nepeta humilis Bentham: First evaluation of phenolic profile and radical scavenging potential

Yazarlar: Alper Gökbulut

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.24 Issue 6, pp.901-907

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348014

pISSN: 2630-6344

Nepeta

Lamiaceae

radical scavenging

HPLC

phenolic compounds

Sayı

Yazarlar:

Alper Gökbulut

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.901-907

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348014

pISSN:

2630-6344