Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H -1,2,4-triazole derivatives

Sultan BAYTAŞ; Evin KAPÇAK; Tülay ÇOBAN; Hatice ÖZBİLGE

doi:https://doi.org/10.3906/sag-1301-136

Makale detayları

Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H -1,2,4-triazole derivatives

Yazarlar:

Sultan BAYTAŞ | Evin KAPÇAK | Tülay ÇOBAN | Hatice ÖZBİLGE

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 6, pp.867-884

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

İngilizce

Document ID (Org No.):

2000727528

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1301-136

Özet:

 

A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H-  1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5-  (substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole  derivatives (5a-p) were synthesized and evaluated for their in vitro  scavenging of DPPH and superoxide radical, and lipid peroxidation  inhibition effects as well as their antimicrobial properties.  DPPH  radical scavenging capacity was found to be equipotent with BHT and  found in compounds containing 1,2,4-triazole-5(4H)-thione moiety  (4a,b).  With regard to antimicrobial properties, compound 5k showed  slight antimicrobial activity against all the test microorganisms.

 

A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H-  1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5-  (substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole  derivatives (5a-p) were synthesized and evaluated for their in vitro  scavenging of DPPH and superoxide radical, and lipid peroxidation  inhibition effects as well as their antimicrobial properties.  DPPH  radical scavenging capacity was found to be equipotent with BHT and  found in compounds containing 1,2,4-triazole-5(4H)-thione moiety  (4a,b).  With regard to antimicrobial properties, compound 5k showed  slight antimicrobial activity against all the test microorganisms.

Makale detayları

Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H -1,2,4-triazole derivatives

Yazarlar: Sultan BAYTAŞ | Evin KAPÇAK | Tülay ÇOBAN | Hatice ÖZBİLGE

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 6, pp.867-884

Belge Tipi: Makale

Yayın Tarihi: 5/2012

Belge Dili: İngilizce

Document ID (Org No.): 2000727528

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/sag-1301-136

Sayı

Yazarlar:

Sultan BAYTAŞ | Evin KAPÇAK | Tülay ÇOBAN | Hatice ÖZBİLGE

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 6, pp.867-884

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

İngilizce

Document ID (Org No.):

2000727528

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/sag-1301-136