Chemical composition and cytotoxic potency of essential oil from Seseli petraeum M. Bieb. (Apiaceae)

Alev Önder; Ahsen Sevde Çınar Koç; Filiz Bakar Ateş; Angel A. Carbonell-barrachina

Makale detayları

Chemical composition and cytotoxic potency of essential oil from Seseli petraeum M. Bieb. (Apiaceae)

Yazarlar:

Alev Önder | Ahsen Sevde Çınar Koç | Filiz Bakar Ateş | Angel A. Carbonell-barrachina

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy | Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.249-257

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347923

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The present study aimed to investigate the chemical composition and in vitro cytotoxic activity of the fruit essential oil of Seseli petraeum M. Bieb. growing in the Northern side of Anatolia. The Seseli petraeum essential oil was obtained by hydrodistillation from the fruits and analyzed by GCMS to determine its chemical composition. The major components have been determined as carotol 17.25, γ-terpinene 10.73, β-farnesene 8.50, p-cymene 7.93, germacrene-D 7.65, and sabinene 7.31. The cytotoxic activity of the essential oil was evaluated by MTT assay in vitro on cell proliferation with MCF-7 Human breast adenocarcinoma and A549 Human lung carcinoma cells. The results showed that the essential oil has potent cytotoxicity against treated cancer cells, whereas it was more cytotoxic in MCF-7 cells IC50390.38 μgmL. The results demonstrated that S. petraeum essential oil has a marked cytotoxic effect against treated cancer cells. Although this effect is likely to be caused by carotol owing to a major component of the oil, further designed studies are necessary due to the possibility of activity, and maybe it occurred due to the synergistic effects of the oil components. The findings of this study may promote the use of the species for pharmaceutical purposes.

 The present study aimed to investigate the chemical composition and in vitro cytotoxic activity of the fruit essential oil of Seseli petraeum M. Bieb. growing in the Northern side of Anatolia. The Seseli petraeum essential oil was obtained by hydrodistillation from the fruits and analyzed by GCMS to determine its chemical composition. The major components have been determined as carotol 17.25, γ-terpinene 10.73, β-farnesene 8.50, p-cymene 7.93, germacrene-D 7.65, and sabinene 7.31. The cytotoxic activity of the essential oil was evaluated by MTT assay in vitro on cell proliferation with MCF-7 Human breast adenocarcinoma and A549 Human lung carcinoma cells. The results showed that the essential oil has potent cytotoxicity against treated cancer cells, whereas it was more cytotoxic in MCF-7 cells IC50390.38 μgmL. The results demonstrated that S. petraeum essential oil has a marked cytotoxic effect against treated cancer cells. Although this effect is likely to be caused by carotol owing to a major component of the oil, further designed studies are necessary due to the possibility of activity, and maybe it occurred due to the synergistic effects of the oil components. The findings of this study may promote the use of the species for pharmaceutical purposes.

 The present study aimed to investigate the chemical composition and in vitro cytotoxic activity of the fruit essential oil of Seseli petraeum M. Bieb. growing in the Northern side of Anatolia. The Seseli petraeum essential oil was obtained by hydrodistillation from the fruits and analyzed by GCMS to determine its chemical composition. The major components have been determined as carotol 17.25, γ-terpinene 10.73, β-farnesene 8.50, p-cymene 7.93, germacrene-D 7.65, and sabinene 7.31. The cytotoxic activity of the essential oil was evaluated by MTT assay in vitro on cell proliferation with MCF-7 Human breast adenocarcinoma and A549 Human lung carcinoma cells. The results showed that the essential oil has potent cytotoxicity against treated cancer cells, whereas it was more cytotoxic in MCF-7 cells IC50390.38 μgmL. The results demonstrated that S. petraeum essential oil has a marked cytotoxic effect against treated cancer cells. Although this effect is likely to be caused by carotol owing to a major component of the oil, further designed studies are necessary due to the possibility of activity, and maybe it occurred due to the synergistic effects of the oil components. The findings of this study may promote the use of the species for pharmaceutical purposes.

 The present study aimed to investigate the chemical composition and in vitro cytotoxic activity of the fruit essential oil of Seseli petraeum M. Bieb. growing in the Northern side of Anatolia. The Seseli petraeum essential oil was obtained by hydrodistillation from the fruits and analyzed by GCMS to determine its chemical composition. The major components have been determined as carotol 17.25, γ-terpinene 10.73, β-farnesene 8.50, p-cymene 7.93, germacrene-D 7.65, and sabinene 7.31. The cytotoxic activity of the essential oil was evaluated by MTT assay in vitro on cell proliferation with MCF-7 Human breast adenocarcinoma and A549 Human lung carcinoma cells. The results showed that the essential oil has potent cytotoxicity against treated cancer cells, whereas it was more cytotoxic in MCF-7 cells IC50390.38 μgmL. The results demonstrated that S. petraeum essential oil has a marked cytotoxic effect against treated cancer cells. Although this effect is likely to be caused by carotol owing to a major component of the oil, further designed studies are necessary due to the possibility of activity, and maybe it occurred due to the synergistic effects of the oil components. The findings of this study may promote the use of the species for pharmaceutical purposes.

Makale detayları

Chemical composition and cytotoxic potency of essential oil from Seseli petraeum M. Bieb. (Apiaceae)

Yazarlar:

Alev Önder | Ahsen Sevde Çınar Koç | Filiz Bakar Ateş | Angel A. Carbonell-barrachina

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy | Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.249-257

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347923

pISSN:

2630-6344

Apiaceae

anticancer

cytotoxicity

essential oil

Seseli.

Sayı

Makale detayları

Chemical composition and cytotoxic potency of essential oil from Seseli petraeum M. Bieb. (Apiaceae)

Yazarlar: Alev Önder | Ahsen Sevde Çınar Koç | Filiz Bakar Ateş | Angel A. Carbonell-barrachina

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy | Pharmaceutical Botany

Dergi: Journal of Research in Pharmacy Vol.25 Issue 3, pp.249-257

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347923

pISSN: 2630-6344

Apiaceae

anticancer

cytotoxicity

essential oil

Seseli.

Sayı

Yazarlar:

Alev Önder | Ahsen Sevde Çınar Koç | Filiz Bakar Ateş | Angel A. Carbonell-barrachina

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy | Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.249-257

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347923

pISSN:

2630-6344