In Vitro Fertilization in 60 Women with Auto-inflammatory or Uncommon Autoimmune Diseases:  A Single-Center Experience

Gül Alkan Bulbul; Emine Kirtiş; Sefa Metehan Ceylan; Şafak Olgan; Murat Özekinci; Cem Sanhal; İnanç Mendilcioğlu

Makale detayları

In Vitro Fertilization in 60 Women with Auto-inflammatory or Uncommon Autoimmune Diseases: A Single-Center Experience

Yazarlar:

Gül Alkan Bulbul | Emine Kirtiş | Sefa Metehan Ceylan | Şafak Olgan | Murat Özekinci | Cem Sanhal | İnanç Mendilcioğlu

Yayıncı:

Akdeniz University

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.396-403

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357306

pISSN:

2687-2781

Anahtar kelimeler:

Özet:

 Objective: Autoimmune and auto-inflammatory diseases can affect both the timing and ability of women to conceive. There is limited data addressing the outcomes of in vitro fertilisation IVF in autoimmune and auto-inflammatory-related infertility. This study presents the IVF experience in women diagnosed with at least one auto-inflammatory disease or autoimmune disorder except for the more common autoimmune disorders that primarily impact the thyroid gland. Material and Methods: A retrospective analysis was performed on women diagnosed with at least one autoimmune or auto-inflammatory disease and had undergone at least one IVF cycle between 2014 and 2023. Results: The study included 60 women who underwent a total of 74 IVF procedures. Rheumatoid arthritis was the most common autoimmune condition, affecting 26.6 of the patients, closely followed by Familial Mediterranean Fever FMF in 25 of the patients. The main factor causing infertility in the sample population was the diminished ovarian reserve, which affected around 64.9 of the participants. The median age at the time of IVF was 33 years. Out of 74 IVF cycles, there were 15 pregnancies, resulting in 9 live births 60 and 6 miscarriages 40. The IVF clinical pregnancy rate was 20.2 and the live birth rate was 12.1. Obstetric complications included one case each of preterm birth, preeclampsia, and fetal growth restriction. No maternal or neonatal deaths occurred, and no cases of ovarian hyperstimulation syndrome were reported. Conclusion: The outcomes of IVF in 60 patients diagnosed with autoimmune and auto-inflammatory diseases were analysed in this study. The IVF procedure exhibited comparatively low pregnancy and live birth rates. However, more than half of the on-going pregnancies resulted in live births. IVF remains a promising option for fertility treatment in patients with autoimmune diseases.

 Objective: Autoimmune and auto-inflammatory diseases can affect both the timing and ability of women to conceive. There is limited data addressing the outcomes of in vitro fertilisation IVF in autoimmune and auto-inflammatory-related infertility. This study presents the IVF experience in women diagnosed with at least one auto-inflammatory disease or autoimmune disorder except for the more common autoimmune disorders that primarily impact the thyroid gland. Material and Methods: A retrospective analysis was performed on women diagnosed with at least one autoimmune or auto-inflammatory disease and had undergone at least one IVF cycle between 2014 and 2023. Results: The study included 60 women who underwent a total of 74 IVF procedures. Rheumatoid arthritis was the most common autoimmune condition, affecting 26.6 of the patients, closely followed by Familial Mediterranean Fever FMF in 25 of the patients. The main factor causing infertility in the sample population was the diminished ovarian reserve, which affected around 64.9 of the participants. The median age at the time of IVF was 33 years. Out of 74 IVF cycles, there were 15 pregnancies, resulting in 9 live births 60 and 6 miscarriages 40. The IVF clinical pregnancy rate was 20.2 and the live birth rate was 12.1. Obstetric complications included one case each of preterm birth, preeclampsia, and fetal growth restriction. No maternal or neonatal deaths occurred, and no cases of ovarian hyperstimulation syndrome were reported. Conclusion: The outcomes of IVF in 60 patients diagnosed with autoimmune and auto-inflammatory diseases were analysed in this study. The IVF procedure exhibited comparatively low pregnancy and live birth rates. However, more than half of the on-going pregnancies resulted in live births. IVF remains a promising option for fertility treatment in patients with autoimmune diseases.

 Objective: Autoimmune and auto-inflammatory diseases can affect both the timing and ability of women to conceive. There is limited data addressing the outcomes of in vitro fertilisation IVF in autoimmune and auto-inflammatory-related infertility. This study presents the IVF experience in women diagnosed with at least one auto-inflammatory disease or autoimmune disorder except for the more common autoimmune disorders that primarily impact the thyroid gland. Material and Methods: A retrospective analysis was performed on women diagnosed with at least one autoimmune or auto-inflammatory disease and had undergone at least one IVF cycle between 2014 and 2023. Results: The study included 60 women who underwent a total of 74 IVF procedures. Rheumatoid arthritis was the most common autoimmune condition, affecting 26.6 of the patients, closely followed by Familial Mediterranean Fever FMF in 25 of the patients. The main factor causing infertility in the sample population was the diminished ovarian reserve, which affected around 64.9 of the participants. The median age at the time of IVF was 33 years. Out of 74 IVF cycles, there were 15 pregnancies, resulting in 9 live births 60 and 6 miscarriages 40. The IVF clinical pregnancy rate was 20.2 and the live birth rate was 12.1. Obstetric complications included one case each of preterm birth, preeclampsia, and fetal growth restriction. No maternal or neonatal deaths occurred, and no cases of ovarian hyperstimulation syndrome were reported. Conclusion: The outcomes of IVF in 60 patients diagnosed with autoimmune and auto-inflammatory diseases were analysed in this study. The IVF procedure exhibited comparatively low pregnancy and live birth rates. However, more than half of the on-going pregnancies resulted in live births. IVF remains a promising option for fertility treatment in patients with autoimmune diseases.

 Amaç: Otoimmün ve otoinflamatuar hastalıklar, kadınların gebe kalma zamanlamasını ve yeteneğini geciktirebilmektedir. Bugüne kadar, otoimmün ve otoinflamatuar hastalıklar ile ilişkili infertilitede İn Vitro Fertilizasyonun IVF sonuçlarına ilişkin çok az veri mevcuttur. Mevcut çalışmada, en sık görülen tiroid bezine karşı otoimmün hastalıklar dışında otoimmün hastalıklardan veya otoinflamatuar hastalıklardan en az birine sahip kadınlarda IVF deneyimini bildirdik. Gereç ve Yöntemler: En az bir otoimmün veya otoinflamatuar hastalığı olan ve 2014 ile 2023 yılları arasında en az bir IVF prosedürü geçirmiş kadınlar üzerinde retrospektif bir analiz yapıldı. Bulgular: Çalışmaya toplam 74 IVF uygulanan 60 kadın dahil edildi. Hastaların 26,6 sını etkileyerek romatoid artrit en sık karşılaşılan otoimmün hastalık olup bunu 25 ile Ailesel Akdeniz Ateşi izledi. Azalmış overyan rezervi infertilitenin birincil nedeniydi ve örnek popülasyonun 64,9unu etkiledi. IVF sırasındaki ortalama yaş 33 idi. Yetmişdört IVF siklusunun 15inde gebelik elde edildi, bunun 9u canlı doğum 60 ve 6sı abortus 40 ile sonuçlandı. IVF klinik gebelik oranı 20,2, canlı doğum oranı ise 12,1 olarak gerçekleşti. Obstetrik komplikasyonlar arasında preterm doğum, preeklampsi ve fetal büyüme kısıtlılığından oluşan birer vaka yer alıyordu. Anne veya yenidoğan ölümü yaşanmadı ve overyan hiperstimülasyon sendromu vakası bildirilmedi. Sonuç: Bu çalışmada otoimmün ve otoinflamatuar hastalıkları olan 60 hastada IVF sonuçlarını analiz ettik. IVF prosedürü, nispeten düşük gebelik ve canlı doğum oranları gösterdi. Bununla birlikte, devam eden gebeliklerin yarıdan fazlası canlı doğum ile sonuçlanmıştır. IVF, otoimmün-otoinflamatuar hastalıkları olan hastalarda doğurganlık tedavisi için umut verici bir seçenek olmaya devam etmektedir.

Makale detayları

In Vitro Fertilization in 60 Women with Auto-inflammatory or Uncommon Autoimmune Diseases: A Single-Center Experience

Yazarlar:

Gül Alkan Bulbul | Emine Kirtiş | Sefa Metehan Ceylan | Şafak Olgan | Murat Özekinci | Cem Sanhal | İnanç Mendilcioğlu

Yayıncı:

Akdeniz University

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.396-403

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357306

pISSN:

2687-2781

autoimmune

auto-inflammatory

in-vitro fertilization

infertility

pregnancyotoimmün

otoinflamatuar

tüp bebek

kısırlık

gebelik

Sayı

Makale detayları

Yazarlar: Gül Alkan Bulbul | Emine Kirtiş | Sefa Metehan Ceylan | Şafak Olgan | Murat Özekinci | Cem Sanhal | İnanç Mendilcioğlu

Yayıncı: Akdeniz University

Ana Başlıklar: Kadın Hastalıkları ve Doğum

Dergi: Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.396-403

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357306

pISSN: 2687-2781

Sayı

Yazarlar:

Gül Alkan Bulbul | Emine Kirtiş | Sefa Metehan Ceylan | Şafak Olgan | Murat Özekinci | Cem Sanhal | İnanç Mendilcioğlu

Yayıncı:

Akdeniz University

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.396-403

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357306

pISSN:

2687-2781