Experimental pharmacology assessment of Agave brittoniana  subsp. brachypus (Trel.) in ulcerative colitis

N.A.

Makale detayları

Experimental pharmacology assessment of Agave brittoniana subsp. brachypus (Trel.) in ulcerative colitis

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1963-1973

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334769

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Ulcerative colitis is a chronic inflammatory bowel disease with an unknown cause. It is characterized by damage to the colonic mucosa, which often results in symptoms such as diarrhea, abdominal pain, and weight loss, ultimately leading to a reduced quality of life. Treatment aims to control inflammation, reduce symptoms, and minimize fluid and nutrient losses. Currently, there is no known cure for ulcerative colitis. The study was carried out to investigate the anti-inflammatory potential of the hydroalcoholic extract HAE and the butanolic fraction FB from Agave brittoniana subsp. brachypus Trel. on acetic acid-induced colitis in rats. Ulcerative colitis was induced in Sprague Dawley rats using 2.5 acetic acid. Three dose levels for both HAE 150-300-600 mgkg and BF 25-50-100 mgkg were evaluated. The study recorded the variation of body weight, macroscopic and microscopic colonic damage index, and colonic myeloperoxidase. Body weight loss was lower in all treated groups compared to the untreated group. Similarly, there were fewer signs of necrosis and tissue damage in the colon in the groups treated with HAE and BF. Agave brittoniana T exhibited an effective anti-inflammatory effect in an experimental model of ulcerative colitis, indicating its potential as a natural treatment for the condition.

 Ulcerative colitis is a chronic inflammatory bowel disease with an unknown cause. It is characterized by damage to the colonic mucosa, which often results in symptoms such as diarrhea, abdominal pain, and weight loss, ultimately leading to a reduced quality of life. Treatment aims to control inflammation, reduce symptoms, and minimize fluid and nutrient losses. Currently, there is no known cure for ulcerative colitis. The study was carried out to investigate the anti-inflammatory potential of the hydroalcoholic extract HAE and the butanolic fraction FB from Agave brittoniana subsp. brachypus Trel. on acetic acid-induced colitis in rats. Ulcerative colitis was induced in Sprague Dawley rats using 2.5 acetic acid. Three dose levels for both HAE 150-300-600 mgkg and BF 25-50-100 mgkg were evaluated. The study recorded the variation of body weight, macroscopic and microscopic colonic damage index, and colonic myeloperoxidase. Body weight loss was lower in all treated groups compared to the untreated group. Similarly, there were fewer signs of necrosis and tissue damage in the colon in the groups treated with HAE and BF. Agave brittoniana T exhibited an effective anti-inflammatory effect in an experimental model of ulcerative colitis, indicating its potential as a natural treatment for the condition.

 Ulcerative colitis is a chronic inflammatory bowel disease with an unknown cause. It is characterized by damage to the colonic mucosa, which often results in symptoms such as diarrhea, abdominal pain, and weight loss, ultimately leading to a reduced quality of life. Treatment aims to control inflammation, reduce symptoms, and minimize fluid and nutrient losses. Currently, there is no known cure for ulcerative colitis. The study was carried out to investigate the anti-inflammatory potential of the hydroalcoholic extract HAE and the butanolic fraction FB from Agave brittoniana subsp. brachypus Trel. on acetic acid-induced colitis in rats. Ulcerative colitis was induced in Sprague Dawley rats using 2.5 acetic acid. Three dose levels for both HAE 150-300-600 mgkg and BF 25-50-100 mgkg were evaluated. The study recorded the variation of body weight, macroscopic and microscopic colonic damage index, and colonic myeloperoxidase. Body weight loss was lower in all treated groups compared to the untreated group. Similarly, there were fewer signs of necrosis and tissue damage in the colon in the groups treated with HAE and BF. Agave brittoniana T exhibited an effective anti-inflammatory effect in an experimental model of ulcerative colitis, indicating its potential as a natural treatment for the condition.

 Ulcerative colitis is a chronic inflammatory bowel disease with an unknown cause. It is characterized by damage to the colonic mucosa, which often results in symptoms such as diarrhea, abdominal pain, and weight loss, ultimately leading to a reduced quality of life. Treatment aims to control inflammation, reduce symptoms, and minimize fluid and nutrient losses. Currently, there is no known cure for ulcerative colitis. The study was carried out to investigate the anti-inflammatory potential of the hydroalcoholic extract HAE and the butanolic fraction FB from Agave brittoniana subsp. brachypus Trel. on acetic acid-induced colitis in rats. Ulcerative colitis was induced in Sprague Dawley rats using 2.5 acetic acid. Three dose levels for both HAE 150-300-600 mgkg and BF 25-50-100 mgkg were evaluated. The study recorded the variation of body weight, macroscopic and microscopic colonic damage index, and colonic myeloperoxidase. Body weight loss was lower in all treated groups compared to the untreated group. Similarly, there were fewer signs of necrosis and tissue damage in the colon in the groups treated with HAE and BF. Agave brittoniana T exhibited an effective anti-inflammatory effect in an experimental model of ulcerative colitis, indicating its potential as a natural treatment for the condition.

Makale detayları

Experimental pharmacology assessment of Agave brittoniana subsp. brachypus (Trel.) in ulcerative colitis

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1963-1973

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334769

pISSN:

2630-6344

colitis

agave

myeloperoxidase

Sprague-Dawley

Sayı

Makale detayları

Experimental pharmacology assessment of Agave brittoniana subsp. brachypus (Trel.) in ulcerative colitis

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Toxicology

Dergi: Journal of Research in Pharmacy Vol.28 Issue 6, pp.1963-1973

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001334769

pISSN: 2630-6344

colitis

agave

myeloperoxidase

Sprague-Dawley

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1963-1973

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334769

pISSN:

2630-6344