Correlation between Erythrocyte Membrane Na+K+ATPase and Plasma Homocysteine Levels in Type 2 Diabetes Patient

Naim UZUN; Ahmet KIZILTUNÇ

Makale detayları

Correlation between Erythrocyte Membrane Na+K+ATPase and Plasma Homocysteine Levels in Type 2 Diabetes Patient

Yazarlar:

Naim UZUN | Ahmet KIZILTUNÇ

Yayıncı:

Ağrı İbrahim Çeçen University

Dergi:

Eastern Anatolian Journal of Science 2015 Vol.1 Issue 2, pp.82-86

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000949841

Sıklık:

İki Yıllık

pISSN:

2149-6137

Özet:

 

Diabetes Mellitus is the most common of the serious metabolic diseases. It is characterized by metabolic abnormalities; by long-term complication. Correlation between erythrocyte membrane Na+K+ATPase and plasma homocysteine levels in patient. This study was conducted in 29 patients with Type II Diabetes Mellitus and 15 healthy controls. Erythrocyte membrane Na+K+ATPase activity and malondialdehyde were measured spectrophotometrically. Plasma homocysteine levels were measured with High Performance Liquid Chromatography method. When compared to the control group, mean plasma homocysteine levels were found to be increased (p<0.001) and mean Na+K+ATPase values of erythrocyte membranes activities were found to be decreased (p<0.05). There was a negative correlation between erythrocyte membrane Na+K+ATPase and plasma homocysteine levels in patient group (p< 0,01; r= - 0,49), but any correlation was not detected  in the control group. Malondialdehyde was measurement in the tip 2 diabetic patients decreased more than control group. We found an increased plasma homocysteine levels and decreased erythrocyte membranes Na+K+ATPase activities in Diabetes Mellitus group. We think that the decrease in activities of Na+K+ATPase may be due to the increased plasma homocysteine levels.  It was concluded that to be more impact in diabetes which is a complicated disease, cell membrane lipids of oxidation with starting negative the table as a result of high homocysteine levels and reduced antioxidant capacity.

Makale detayları

Correlation between Erythrocyte Membrane Na+K+ATPase and Plasma Homocysteine Levels in Type 2 Diabetes Patient

Yazarlar: Naim UZUN | Ahmet KIZILTUNÇ

Yayıncı: Ağrı İbrahim Çeçen University

Dergi: Eastern Anatolian Journal of Science 2015 Vol.1 Issue 2, pp.82-86

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000949841

Sıklık: İki Yıllık

pISSN: 2149-6137

Sayı

Yazarlar:

Naim UZUN | Ahmet KIZILTUNÇ

Yayıncı:

Ağrı İbrahim Çeçen University

Dergi:

Eastern Anatolian Journal of Science 2015 Vol.1 Issue 2, pp.82-86

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000949841

Sıklık:

İki Yıllık

pISSN:

2149-6137