Should encountering atypia of undetermined significance / follicular lesion of undetermined significance after thyroid biopsy lead to the operation?

Bilgin Çelebi; Halil Afşin Taşdelen; Eray Kurnaz

Makale detayları

Should encountering atypia of undetermined significance / follicular lesion of undetermined significance after thyroid biopsy lead to the operation?

Yazarlar:

Bilgin Çelebi | Halil Afşin Taşdelen | Eray Kurnaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Surgery

Dergi:

The European Research Journal Vol.9 Issue 4, pp.708-716

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287588

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Nodular goiter is the most common disease of the thyroid gland. Thyroid nodules are malignant in 3-5 cases. To determine the incidence of malignancy in patients defined as atypia of undetermined significance AUS or follicular lesion of undetermined significance FLUS as a result of fine needle aspiration biopsy FNAB and evaluate the clinical, biochemical and sonographic features as possible predictors of malignancy. Methods: Patients who had undergone at least one FNAB and diagnosed as AUSFLUS from January 2011 to December 2015 were included in the study. Age, gender, benign disease, thyroid stimulating hormone TSH level, size, localization, number, time of FNAB, ultrasonography USG characteristics, follow-up data on repeated FNAB results and, if surgical excision was performed, final pathological results were analyzed. Results: A total of 5181 thyroid nodules were biopsied in 4089 patients, and the biopsy specimen taken from 611 nodules was diagnosed histopathologically as AUSFLUS 11.79. After FNAB, 167 of 611 patients diagnosed with AUSFLUS were operated. While 65.9 n  110 of 167 patients who underwent surgery were made a benign diagnosis; malign diagnosis was made to 34.1 n  57. Conclusions: The rate of malignancy in surgically confirmed nodules was 34.1 in this study, which is higher than the Bethesda classification. Due to the high malignancy rate which determined in cytologically diagnosed AUSFLUS, we think that the repeat decision of the FNAB should be reconsidered and the surgical plan after the first FNAB should be considered more seriously.

 Objectives: Nodular goiter is the most common disease of the thyroid gland. Thyroid nodules are malignant in 3-5 cases. To determine the incidence of malignancy in patients defined as atypia of undetermined significance AUS or follicular lesion of undetermined significance FLUS as a result of fine needle aspiration biopsy FNAB and evaluate the clinical, biochemical and sonographic features as possible predictors of malignancy. Methods: Patients who had undergone at least one FNAB and diagnosed as AUSFLUS from January 2011 to December 2015 were included in the study. Age, gender, benign disease, thyroid stimulating hormone TSH level, size, localization, number, time of FNAB, ultrasonography USG characteristics, follow-up data on repeated FNAB results and, if surgical excision was performed, final pathological results were analyzed. Results: A total of 5181 thyroid nodules were biopsied in 4089 patients, and the biopsy specimen taken from 611 nodules was diagnosed histopathologically as AUSFLUS 11.79. After FNAB, 167 of 611 patients diagnosed with AUSFLUS were operated. While 65.9 n  110 of 167 patients who underwent surgery were made a benign diagnosis; malign diagnosis was made to 34.1 n  57. Conclusions: The rate of malignancy in surgically confirmed nodules was 34.1 in this study, which is higher than the Bethesda classification. Due to the high malignancy rate which determined in cytologically diagnosed AUSFLUS, we think that the repeat decision of the FNAB should be reconsidered and the surgical plan after the first FNAB should be considered more seriously.

 Objectives: Nodular goiter is the most common disease of the thyroid gland. Thyroid nodules are malignant in 3-5 cases. To determine the incidence of malignancy in patients defined as atypia of undetermined significance AUS or follicular lesion of undetermined significance FLUS as a result of fine needle aspiration biopsy FNAB and evaluate the clinical, biochemical and sonographic features as possible predictors of malignancy. Methods: Patients who had undergone at least one FNAB and diagnosed as AUSFLUS from January 2011 to December 2015 were included in the study. Age, gender, benign disease, thyroid stimulating hormone TSH level, size, localization, number, time of FNAB, ultrasonography USG characteristics, follow-up data on repeated FNAB results and, if surgical excision was performed, final pathological results were analyzed. Results: A total of 5181 thyroid nodules were biopsied in 4089 patients, and the biopsy specimen taken from 611 nodules was diagnosed histopathologically as AUSFLUS 11.79. After FNAB, 167 of 611 patients diagnosed with AUSFLUS were operated. While 65.9 n  110 of 167 patients who underwent surgery were made a benign diagnosis; malign diagnosis was made to 34.1 n  57. Conclusions: The rate of malignancy in surgically confirmed nodules was 34.1 in this study, which is higher than the Bethesda classification. Due to the high malignancy rate which determined in cytologically diagnosed AUSFLUS, we think that the repeat decision of the FNAB should be reconsidered and the surgical plan after the first FNAB should be considered more seriously.

 Objectives: Nodular goiter is the most common disease of the thyroid gland. Thyroid nodules are malignant in 3-5 cases. To determine the incidence of malignancy in patients defined as atypia of undetermined significance AUS or follicular lesion of undetermined significance FLUS as a result of fine needle aspiration biopsy FNAB and evaluate the clinical, biochemical and sonographic features as possible predictors of malignancy. Methods: Patients who had undergone at least one FNAB and diagnosed as AUSFLUS from January 2011 to December 2015 were included in the study. Age, gender, benign disease, thyroid stimulating hormone TSH level, size, localization, number, time of FNAB, ultrasonography USG characteristics, follow-up data on repeated FNAB results and, if surgical excision was performed, final pathological results were analyzed. Results: A total of 5181 thyroid nodules were biopsied in 4089 patients, and the biopsy specimen taken from 611 nodules was diagnosed histopathologically as AUSFLUS 11.79. After FNAB, 167 of 611 patients diagnosed with AUSFLUS were operated. While 65.9 n  110 of 167 patients who underwent surgery were made a benign diagnosis; malign diagnosis was made to 34.1 n  57. Conclusions: The rate of malignancy in surgically confirmed nodules was 34.1 in this study, which is higher than the Bethesda classification. Due to the high malignancy rate which determined in cytologically diagnosed AUSFLUS, we think that the repeat decision of the FNAB should be reconsidered and the surgical plan after the first FNAB should be considered more seriously.

Makale detayları

Should encountering atypia of undetermined significance / follicular lesion of undetermined significance after thyroid biopsy lead to the operation?

Yazarlar:

Bilgin Çelebi | Halil Afşin Taşdelen | Eray Kurnaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Surgery

Dergi:

The European Research Journal Vol.9 Issue 4, pp.708-716

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287588

pISSN:

2149-3189

Thyroid biopsy

thyroid cancer

thyroidectomy

Sayı

Makale detayları

Should encountering atypia of undetermined significance / follicular lesion of undetermined significance after thyroid biopsy lead to the operation?

Yazarlar: Bilgin Çelebi | Halil Afşin Taşdelen | Eray Kurnaz

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Surgery

Dergi: The European Research Journal Vol.9 Issue 4, pp.708-716

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001287588

pISSN: 2149-3189

Thyroid biopsy

thyroid cancer

thyroidectomy

Sayı

Yazarlar:

Bilgin Çelebi | Halil Afşin Taşdelen | Eray Kurnaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Surgery

Dergi:

The European Research Journal Vol.9 Issue 4, pp.708-716

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287588

pISSN:

2149-3189