The usefulness of arylesterase in predicting contrast-induced nephropathy in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

Süleyman Kalaycı; Ayse Ceylan Hamamcıoglu; Belma Kalaycı

Makale detayları

The usefulness of arylesterase in predicting contrast-induced nephropathy in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

Yazarlar:

Süleyman Kalaycı | Ayse Ceylan Hamamcıoglu | Belma Kalaycı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.244-249

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286238

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aim: Oxidative stress is one of the causes of contrast-induced nephropathy CIN. Paraoxonase1 PON1, is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase AREase activity. To explore relationship between AREase activity and CIN development. Material and Method: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN  and CIN -. The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis. Results: Out of the study patients, 13 were CIN  and 45 were CIN -. AREase activity was found to be statistically significantly lower in the CIN  group 875 UL vs 819 UL, p 0.004. In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level 824.1 UL predicted the development of CIN with 61.5 sensitivity and 86.7 specificity AUC 0.768, 95 CI 0.638-0.868, p0.001. Conclusion: AREase level is an independent risk factor for the development of CIN and can be used for the prediction of CIN development.

 Aim: Oxidative stress is one of the causes of contrast-induced nephropathy CIN. Paraoxonase1 PON1, is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase AREase activity. To explore relationship between AREase activity and CIN development. Material and Method: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN  and CIN -. The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis. Results: Out of the study patients, 13 were CIN  and 45 were CIN -. AREase activity was found to be statistically significantly lower in the CIN  group 875 UL vs 819 UL, p 0.004. In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level 824.1 UL predicted the development of CIN with 61.5 sensitivity and 86.7 specificity AUC 0.768, 95 CI 0.638-0.868, p0.001. Conclusion: AREase level is an independent risk factor for the development of CIN and can be used for the prediction of CIN development.

 Aim: Oxidative stress is one of the causes of contrast-induced nephropathy CIN. Paraoxonase1 PON1, is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase AREase activity. To explore relationship between AREase activity and CIN development. Material and Method: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN  and CIN -. The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis. Results: Out of the study patients, 13 were CIN  and 45 were CIN -. AREase activity was found to be statistically significantly lower in the CIN  group 875 UL vs 819 UL, p 0.004. In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level 824.1 UL predicted the development of CIN with 61.5 sensitivity and 86.7 specificity AUC 0.768, 95 CI 0.638-0.868, p0.001. Conclusion: AREase level is an independent risk factor for the development of CIN and can be used for the prediction of CIN development.

 Aim: Oxidative stress is one of the causes of contrast-induced nephropathy CIN. Paraoxonase1 PON1, is one of the oxidative stress markers. The most sensitive method that has been in use to measure PON1 enzyme activity is the measurement of arylesterase AREase activity. To explore relationship between AREase activity and CIN development. Material and Method: A total of 58 STEMI patients were included in our study. The patients were divided into two groups as CIN  and CIN -. The success of AREase activity level in predicting the development of CIN was also examined by using ROC analysis. Results: Out of the study patients, 13 were CIN  and 45 were CIN -. AREase activity was found to be statistically significantly lower in the CIN  group 875 UL vs 819 UL, p 0.004. In the regression analysis, diabetes mellitus, contrast volume and AREase activity were determined as independent risk factors in the development of CIN. As a result of the ROC analysis, we concluded that the AREase activity level 824.1 UL predicted the development of CIN with 61.5 sensitivity and 86.7 specificity AUC 0.768, 95 CI 0.638-0.868, p0.001. Conclusion: AREase level is an independent risk factor for the development of CIN and can be used for the prediction of CIN development.

Makale detayları

The usefulness of arylesterase in predicting contrast-induced nephropathy in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

Yazarlar:

Süleyman Kalaycı | Ayse Ceylan Hamamcıoglu | Belma Kalaycı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.244-249

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286238

pISSN:

2636-8579

Acute myocardial infarction/STEMI

angiography

coronary

coronary artery disease

percutaneous coronary Intervention (PCI)

renal disease

acute

Acute myocardial infarction/STEMI; Angiography

Coronary; Coronary Artery Disease; Percutaneous Coronary Intervention (PCI); Renal Disease

Acute

Acute myocardial infarction

Coronary Artery Disease

Coronary Artery Disease

Percutaneous Coronary Intervention

Sayı

Makale detayları

Yazarlar: Süleyman Kalaycı | Ayse Ceylan Hamamcıoglu | Belma Kalaycı

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.244-249

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286238

pISSN: 2636-8579

Sayı

Yazarlar:

Süleyman Kalaycı | Ayse Ceylan Hamamcıoglu | Belma Kalaycı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.244-249

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286238

pISSN:

2636-8579