Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea

Gözde Demirci SAĞLAM; Adil ZAMANİ; Şebnem YOSUNKAYA; İbrahim KILINÇ

Makale detayları

Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea

Yazarlar:

Gözde Demirci SAĞLAM | Adil ZAMANİ | Şebnem YOSUNKAYA | İbrahim KILINÇ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.746-754

Belge Tipi:

Makale

Yayın Tarihi:

5/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750073

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:  Obstructive  sleep  apnea  (OSA)  is  associated  with  serious  cardiometabolic  risks.  Early  diagnosis  and  treatment  compliance  are  important.  For  this  purpose,  research  is  being  carried  out  on  biomarkers  associated  with  the  pathogenesis  of  the  disease. We aimed to investigate whether serum S100A12 and S100B proteins could be used as biochemical markers in OSA patients to determine disease presence and severity. Materials and methods: A total of 60 (16 women, 44 men) patients with OSA and 50 (20 women, 30 men) controls were enrolled in this cross-sectional study. Each subject included in the study underwent full-night polysomnography (PSG). The presence and severity of OSA was assessed with the apnea-hypopnea index (AHI). In the OSA group, 17 cases were mild, 18 were moderate, and 25 were severe.The  serum  levels  of  S100A12  and  S100B  were  measured  using  the  enzyme-linked  immunosorbent  assay  (ELISA)  technique.  These protein levels were compared using Student's t-test in the patient and control groups. Spearman's rho correlation coefficients and corresponding P-values were calculated to determine the correlations between these protein levels and polysomnographic parameters. For  evaluating  the  association  between  OSA  and  biomarkers,  as  well  as  possible  confounding  factors  with  S100A12  and  S100B,  we  employed multiple linear regression analyses for the patients with OSA.Results: Serum levels of S100A12 and S100B were higher in patients than those in controls (P = 0.01 and P = 0.005, respectively), and a significant correlation was determined between S100A12 and S100B values and AHI (P = 0.0001; P = 0.0001), sleep time with SpO2 < 90% (P = 0.032; P = 0.01), minimum SpO2 during sleep (P = 0.019; P = 0.007), and oxygen desaturation index (ODI) (P = 0.001; P =  0.0001).  In  the  linear  regression  analysis,  AHI  was  independently  related  with  both  S100A12  (P  <  0.0001)  and  S100B  (P  =  0.011).  Receiving operating curves (ROC) identified patients with OSA: AUC for S100A12 = 0.643; AUC for S100B = 0.655 (P < 0.05).Conclusion: Serum levels of S100B and S100A proteins have high diagnostic performance in OSA and are independent predictors of OSA presence and severity.

Makale detayları

Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea

Yazarlar: Gözde Demirci SAĞLAM | Adil ZAMANİ | Şebnem YOSUNKAYA | İbrahim KILINÇ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.746-754

Belge Tipi: Makale

Yayın Tarihi: 5/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000750073

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Gözde Demirci SAĞLAM | Adil ZAMANİ | Şebnem YOSUNKAYA | İbrahim KILINÇ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.746-754

Belge Tipi:

Makale

Yayın Tarihi:

5/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000750073

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144