A Natural Hope for Salivary Gland Health: Histological Evaluation of Cinnamic Acid in Diabetic Rats

Doğa Kılınç; Seval Türk; Gülsüm Betül Özyurt; Mustafa Öztop

Makale detayları

A Natural Hope for Salivary Gland Health: Histological Evaluation of Cinnamic Acid in Diabetic Rats

Yazarlar:

Doğa Kılınç | Seval Türk | Gülsüm Betül Özyurt | Mustafa Öztop

Yayıncı:

Marmara University

Ana Başlıklar:

Oral Medicine and Pathology | Dentistry (Other) | Endocrinology | Gastroenterology and Hepatology | Pathology

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.447-452

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352341

pISSN:

2459-1459

Anahtar kelimeler:

Özet:

 Objective: The aim of this study was to investigate the possible potential of cinnamic acid in preserving the structure and function of the parotid gland in diabetic rats. Methods: The rats n32 were equally divided into four groups: Control only physiological serum, Cinnamic acid cinnamic acid 50 mgkgday, Streptozotocin-induced diabetes experimentally-induced diabetes by intraperitoneal injection of streptozotocin 65 mgkg, and Diabetes  cinnamic acid cinnamic acid after diabetes induction. After the rats were sacrificed, tissue samples were obtained and processed for paraffin embedding. To visualize the histological structure, HematoxylinEosin, Massons Trichrome, and Periodic Acid-Schiff histochemical stains were applied, and images were captured. Results: While normal serous acini, canal structures and normal connective tissue were observed in the control and cinnamic acid groups, deformation and atrophy were observed in some acinar cells in the diabetic group. In the treatment group, improvement in the shape of acinar cells and regular arrangement of parietal cells in glandular canals were noted compared to the diabetic group. The intense vacuolization observed in acinar cells in the diabetic group decreased in the treatment group. Periodic Acid-Schiff -positive reaction was determined in the basement membranes of acinar cells and parietal cells in glandular canals in all groups. No visible difference was obtained between the groups. Conclusion: Diabetes affects the parotid gland, and cinnamic acid has been shown to prove a healing effect on deformed areas. Our study will guide further research in this area.

 Objective: The aim of this study was to investigate the possible potential of cinnamic acid in preserving the structure and function of the parotid gland in diabetic rats. Methods: The rats n32 were equally divided into four groups: Control only physiological serum, Cinnamic acid cinnamic acid 50 mgkgday, Streptozotocin-induced diabetes experimentally-induced diabetes by intraperitoneal injection of streptozotocin 65 mgkg, and Diabetes  cinnamic acid cinnamic acid after diabetes induction. After the rats were sacrificed, tissue samples were obtained and processed for paraffin embedding. To visualize the histological structure, HematoxylinEosin, Massons Trichrome, and Periodic Acid-Schiff histochemical stains were applied, and images were captured. Results: While normal serous acini, canal structures and normal connective tissue were observed in the control and cinnamic acid groups, deformation and atrophy were observed in some acinar cells in the diabetic group. In the treatment group, improvement in the shape of acinar cells and regular arrangement of parietal cells in glandular canals were noted compared to the diabetic group. The intense vacuolization observed in acinar cells in the diabetic group decreased in the treatment group. Periodic Acid-Schiff -positive reaction was determined in the basement membranes of acinar cells and parietal cells in glandular canals in all groups. No visible difference was obtained between the groups. Conclusion: Diabetes affects the parotid gland, and cinnamic acid has been shown to prove a healing effect on deformed areas. Our study will guide further research in this area.

 Objective: The aim of this study was to investigate the possible potential of cinnamic acid in preserving the structure and function of the parotid gland in diabetic rats. Methods: The rats n32 were equally divided into four groups: Control only physiological serum, Cinnamic acid cinnamic acid 50 mgkgday, Streptozotocin-induced diabetes experimentally-induced diabetes by intraperitoneal injection of streptozotocin 65 mgkg, and Diabetes  cinnamic acid cinnamic acid after diabetes induction. After the rats were sacrificed, tissue samples were obtained and processed for paraffin embedding. To visualize the histological structure, HematoxylinEosin, Massons Trichrome, and Periodic Acid-Schiff histochemical stains were applied, and images were captured. Results: While normal serous acini, canal structures and normal connective tissue were observed in the control and cinnamic acid groups, deformation and atrophy were observed in some acinar cells in the diabetic group. In the treatment group, improvement in the shape of acinar cells and regular arrangement of parietal cells in glandular canals were noted compared to the diabetic group. The intense vacuolization observed in acinar cells in the diabetic group decreased in the treatment group. Periodic Acid-Schiff -positive reaction was determined in the basement membranes of acinar cells and parietal cells in glandular canals in all groups. No visible difference was obtained between the groups. Conclusion: Diabetes affects the parotid gland, and cinnamic acid has been shown to prove a healing effect on deformed areas. Our study will guide further research in this area.

 Objective: The aim of this study was to investigate the possible potential of cinnamic acid in preserving the structure and function of the parotid gland in diabetic rats. Methods: The rats n32 were equally divided into four groups: Control only physiological serum, Cinnamic acid cinnamic acid 50 mgkgday, Streptozotocin-induced diabetes experimentally-induced diabetes by intraperitoneal injection of streptozotocin 65 mgkg, and Diabetes  cinnamic acid cinnamic acid after diabetes induction. After the rats were sacrificed, tissue samples were obtained and processed for paraffin embedding. To visualize the histological structure, HematoxylinEosin, Massons Trichrome, and Periodic Acid-Schiff histochemical stains were applied, and images were captured. Results: While normal serous acini, canal structures and normal connective tissue were observed in the control and cinnamic acid groups, deformation and atrophy were observed in some acinar cells in the diabetic group. In the treatment group, improvement in the shape of acinar cells and regular arrangement of parietal cells in glandular canals were noted compared to the diabetic group. The intense vacuolization observed in acinar cells in the diabetic group decreased in the treatment group. Periodic Acid-Schiff -positive reaction was determined in the basement membranes of acinar cells and parietal cells in glandular canals in all groups. No visible difference was obtained between the groups. Conclusion: Diabetes affects the parotid gland, and cinnamic acid has been shown to prove a healing effect on deformed areas. Our study will guide further research in this area.

Makale detayları

A Natural Hope for Salivary Gland Health: Histological Evaluation of Cinnamic Acid in Diabetic Rats

Yazarlar:

Doğa Kılınç | Seval Türk | Gülsüm Betül Özyurt | Mustafa Öztop

Yayıncı:

Marmara University

Ana Başlıklar:

Oral Medicine and Pathology | Dentistry (Other) | Endocrinology | Gastroenterology and Hepatology | Pathology

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.447-452

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352341

pISSN:

2459-1459

Type 1 diabetes

cinnamic acid

parotid gland

histology

Sayı

Makale detayları

A Natural Hope for Salivary Gland Health: Histological Evaluation of Cinnamic Acid in Diabetic Rats

Yazarlar: Doğa Kılınç | Seval Türk | Gülsüm Betül Özyurt | Mustafa Öztop

Yayıncı: Marmara University

Ana Başlıklar: Oral Medicine and Pathology | Dentistry (Other) | Endocrinology | Gastroenterology and Hepatology | Pathology

Dergi: Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.447-452

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001352341

pISSN: 2459-1459

Type 1 diabetes

cinnamic acid

parotid gland

histology

Sayı

Yazarlar:

Doğa Kılınç | Seval Türk | Gülsüm Betül Özyurt | Mustafa Öztop

Yayıncı:

Marmara University

Ana Başlıklar:

Oral Medicine and Pathology | Dentistry (Other) | Endocrinology | Gastroenterology and Hepatology | Pathology

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.447-452

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352341

pISSN:

2459-1459