Emerging biomarker for predicting acute kidney injury after cardiac surgery: cystatin C

Onur SAYDAM; Ercan TÜRKMEN; Oytun PORTAKAL; Mustafa ARICI; Rıza DOĞAN; Metin DEMİRCİN; İlhan PAŞAOĞLU; Mustafa YILMAZ

Makale detayları

Emerging biomarker for predicting acute kidney injury after cardiac surgery: cystatin C

Yazarlar:

Onur SAYDAM | Ercan TÜRKMEN | Oytun PORTAKAL | Mustafa ARICI | Rıza DOĞAN | Metin DEMİRCİN | İlhan PAŞAOĞLU | Mustafa YILMAZ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1096-1103

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750427

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 


 
                         Background/aim:
  Cardiopulmonary  bypass  (CPB)-associated  acute  kidney  injury  (AKI)  is  a  common  situation  and  rapid  diagnosis  
and risk classification are important in the prevention and management of AKI. Changes in serum creatinine (SCr) levels in the current 
consensus criteria do not allow clinicians to diagnose CPB-associated AKI until 48 h after surgery. 
Materials  and  methods:
  We  conducted  a  prospective  single  center  study  involving  57  patients  who  underwent  cardiac  surgery  with  
CBP  to  compare  serum  beta-trace  protein  (BTP),  neutrophil  gelatinase-associated  lipocalin-2  (NGAL),  and  cystatin  C  (CysC)  levels  
with SCr for early diagnosis of CPB associated AKI. We defined AKI according to KDIGO criteria. 
Results:
 AKI was diagnosed in 24 (42.1%) patients. Mean duration of postoperative intensive care unit stay was 4.79 (± 6.12) days for the 
AKI+ group and 2.15 (± 0.56) days for the AKI- group. The average length of hospital stay was 8.13 (± 5.75) days for the AKI+ group and 
7.21 (± 3.68) days for the AKI- group, which was significantly longer in the AKI+ group (P < 0.001, P = 0.011). Unlike other biomarkers, 
a significant increase in postoperative CysC levels was always found in patients with AKI during follow-up when compared to patients 
in whom AKI did not develop (P < 0.001). 
Conclusion:
 Increase in serum CysC levels showed a significant positive correlation with increase in SCr levels. We have not seen this 
correlation between other biomarkers and SCr. According to our study, serum CysC was a reliable biomarker that may aid in the early 
detection and follow-up of AKI after cardiac surgery.
                    

.

Makale detayları

Emerging biomarker for predicting acute kidney injury after cardiac surgery: cystatin C

Yazarlar: Onur SAYDAM | Ercan TÜRKMEN | Oytun PORTAKAL | Mustafa ARICI | Rıza DOĞAN | Metin DEMİRCİN | İlhan PAŞAOĞLU | Mustafa YILMAZ

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1096-1103

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000750427

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Onur SAYDAM | Ercan TÜRKMEN | Oytun PORTAKAL | Mustafa ARICI | Rıza DOĞAN | Metin DEMİRCİN | İlhan PAŞAOĞLU | Mustafa YILMAZ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1096-1103

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750427

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144