Comparison of FMF Gene Mutations in Our Region with World Distribution

Doğu Karahan

Makale detayları

Comparison of FMF Gene Mutations in Our Region with World Distribution

Yazarlar:

Doğu Karahan

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.19 Issue 2, pp.15-20

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001322847

pISSN:

1303-6610

Anahtar kelimeler:

Özet:

 Objective: Although Familial Mediterranean Fever FMF is endemic, especially in the Eastern Mediterranean basin societies, it has recently been detected in different countries in the world with social migrations. This study, it is aimed to compare the genetic mutations that are seen frequently in Turkey with the mutations in different populations. Material and Methods: The genetic mutation test results of 192 FMF patients were screened retrospectively, mutations were detected and their frequencies were calculated. The detected mutations were evaluated by comparing them with previous studies conducted in Turkey and other populations. Results: In our study, the most common mutations were M694V 29.68, G148G 17.18, M680I 12.5, and V726A 10.93. It was determined that A202 genetic variation was the most common variable with 58.85. While the results were similar to the results of most other studies in Turkey, it was observed that the frequency of mutations changed in different populations. Conclusion: FMF is endemic in the Eastern Mediterranean basin, less frequently in other parts of the Mediterranean. In addition, it has been detected more frequently in distant regions of the world in recent years. Social migrations and genetic transmission are held responsible for this increase. The frequency of mutations seen in different societies also varies, and this gives an idea about the genetic origin of the migration to those regions. Considering that mass migration has increased recently, the importance of FMF disease and mutation distribution in the world seems to increase in the future.

 Objective: Although Familial Mediterranean Fever FMF is endemic, especially in the Eastern Mediterranean basin societies, it has recently been detected in different countries in the world with social migrations. This study, it is aimed to compare the genetic mutations that are seen frequently in Turkey with the mutations in different populations. Material and Methods: The genetic mutation test results of 192 FMF patients were screened retrospectively, mutations were detected and their frequencies were calculated. The detected mutations were evaluated by comparing them with previous studies conducted in Turkey and other populations. Results: In our study, the most common mutations were M694V 29.68, G148G 17.18, M680I 12.5, and V726A 10.93. It was determined that A202 genetic variation was the most common variable with 58.85. While the results were similar to the results of most other studies in Turkey, it was observed that the frequency of mutations changed in different populations. Conclusion: FMF is endemic in the Eastern Mediterranean basin, less frequently in other parts of the Mediterranean. In addition, it has been detected more frequently in distant regions of the world in recent years. Social migrations and genetic transmission are held responsible for this increase. The frequency of mutations seen in different societies also varies, and this gives an idea about the genetic origin of the migration to those regions. Considering that mass migration has increased recently, the importance of FMF disease and mutation distribution in the world seems to increase in the future.

 Objective: Although Familial Mediterranean Fever FMF is endemic, especially in the Eastern Mediterranean basin societies, it has recently been detected in different countries in the world with social migrations. This study, it is aimed to compare the genetic mutations that are seen frequently in Turkey with the mutations in different populations. Material and Methods: The genetic mutation test results of 192 FMF patients were screened retrospectively, mutations were detected and their frequencies were calculated. The detected mutations were evaluated by comparing them with previous studies conducted in Turkey and other populations. Results: In our study, the most common mutations were M694V 29.68, G148G 17.18, M680I 12.5, and V726A 10.93. It was determined that A202 genetic variation was the most common variable with 58.85. While the results were similar to the results of most other studies in Turkey, it was observed that the frequency of mutations changed in different populations. Conclusion: FMF is endemic in the Eastern Mediterranean basin, less frequently in other parts of the Mediterranean. In addition, it has been detected more frequently in distant regions of the world in recent years. Social migrations and genetic transmission are held responsible for this increase. The frequency of mutations seen in different societies also varies, and this gives an idea about the genetic origin of the migration to those regions. Considering that mass migration has increased recently, the importance of FMF disease and mutation distribution in the world seems to increase in the future.

 Amaç: Ailevi Akdeniz Ateşi FMF, özellikle Doğu Akdeniz havzası toplumlarında endemik olmakla birlikte toplumsal göçlerle birlikte dünyada farklı ülkelerde de son dönemlerde tespit edilmektedir. Bu çalışmada Türkiyede sık görülen genetik mutasyonlar ile farklı toplumlardaki mutasyonların karşılaştırması amaçlanmıştır. Gereç ve Yöntemler: 192 FMF hastasının genetik mutasyon test sonuçları retrospektif olarak taranarak mutasyonlar tespit edildi ve sıklıkları hesaplandı. Tespit edilen mutasyonlar Türkiyede ve diğer toplumlarda yapılmış olan önceki çalışmalar ile karşılaştırılarak değerlendirildi. Bulgular: Çalışmamızda en sık mutasyonların M694V 29.68, G148G 17.18, M680I 12.5 ve V726A 10.93 olduğu görüldü. A202 genetik varyasyonun 58.85 ile görülen en sık değişken olduğu saptandı. Sonuçlar sıklık açısından Türkiyedeki diğer çoğu çalışmanın sonuçları ile benzer iken farklı toplumlarda mutasyon sıklığının değiştiği gözlemlendi. Sonuç: FMF Doğu Akdeniz havzasında endemik olarak görülmekte, Akdenizin diğer bölgelerinde daha az sıklıkla görülmektedir. Ayrıca dünyada uzak bölgelerde de son dönemlerde daha sıklıkla saptanmaktadır. Toplumsal göçler ve genetik transmisyon bu artıştan sorumlu tutulmaktadır. Farklı toplumlarda görülen mutasyonların sıklığı da değişkenlik göstermekte olup bu durum o bölgelere olan göçün genetik kökeni açısından da fikir vermektedir. Son dönemlerde kitlesel göçlerin arttığı düşünüldüğünde dünyada FMF hastalığı ve mutasyon dağılımının önemi artacak gibi görünmektedir.

Makale detayları

Comparison of FMF Gene Mutations in Our Region with World Distribution

Yazarlar:

Doğu Karahan

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.19 Issue 2, pp.15-20

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001322847

pISSN:

1303-6610

FMF

genetic

mediterrenian

mutation

transmissionakdeniz

FMF

genetik

mutasyon

transmisyon

Sayı

Makale detayları

Yazarlar: Doğu Karahan

Yayıncı: Kahramanmaras Sutcu Imam University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.19 Issue 2, pp.15-20

Belge Tipi: Makale

Yayın Tarihi: 7/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001322847

pISSN: 1303-6610

Sayı

Yazarlar:

Doğu Karahan

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.19 Issue 2, pp.15-20

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001322847

pISSN:

1303-6610