Effects of Lacosamide in Rats with Lipopolysaccharide Induced Hepatic Pathology

Özlem ÖZMEN; Volkan İPEK

doi:https://doi.org/10.30782/jrvm.665878

Makale detayları

Effects of Lacosamide in Rats with Lipopolysaccharide Induced Hepatic Pathology

Yazarlar:

Özlem ÖZMEN | Volkan İPEK

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Hayvancılık

Dergi:

Journal of Research in Veterinary Medicine 2020 Vol.39 Issue 1, pp.54-60

Belge Tipi:

Makale

Yayın Tarihi:

7/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493951

Sıklık:

İki Yıllık

eISSN:

2667-6745

DOI:

https://doi.org/10.30782/jrvm.665878

Özet:

 

Bacterial lipopolysaccharides (LPS) generally increase the pathogenicity of the agent. This study aimed to examine the hepatic pathology and possible prophylactic effects of lacosamide (LCM) in a LPS-induced sepsis rat model. Overall, 24 1-year-old female Wistar Albino rats were divided into three groups: Group I (control), Group II (LPS group: 5 mg/kg LPS intraperitoneally, single dose), and Group III (LCM group: 40 mg/kg LCM intraperitoneally once daily for 3 days plus 5 mg/kg LPS 30 min after the last LCM treatment). Animals were euthanized 6 hours after LPS administration. Blood and liver samples collected during necropsy were analyzed biochemically, pathologically, and immunohistochemically. LPS caused a significant increase in serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, direct bilirubin, indirect bilirubin, and alkaline phosphatase levels. Histopathological analysis revealed numerous neutrophil leucocyte infiltrations, slight hemorrhages in the liver, and degenerative or necrotic changes in hepatocytes. Increased expressions of malondialdehyde, C-reactive protein, heat shock protein-70, interleukin-1β, and tumor necrosis factor-α were observed in the LPS administered group. LCM ameliorated the biochemical, histopathological, and immunohistochemical findings. The present study results revealed that LCM ameliorated the LPS-induced liver damage in the rat models as evidenced by the biochemical and pathological findings.

Makale detayları

Effects of Lacosamide in Rats with Lipopolysaccharide Induced Hepatic Pathology

Yazarlar: Özlem ÖZMEN | Volkan İPEK

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Hayvancılık

Dergi: Journal of Research in Veterinary Medicine 2020 Vol.39 Issue 1, pp.54-60

Belge Tipi: Makale

Yayın Tarihi: 7/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000493951

Sıklık: İki Yıllık

eISSN: 2667-6745

DOI: https://doi.org/10.30782/jrvm.665878

Sayı

Yazarlar:

Özlem ÖZMEN | Volkan İPEK

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Hayvancılık

Dergi:

Journal of Research in Veterinary Medicine 2020 Vol.39 Issue 1, pp.54-60

Belge Tipi:

Makale

Yayın Tarihi:

7/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000493951

Sıklık:

İki Yıllık

eISSN:

2667-6745

DOI:

https://doi.org/10.30782/jrvm.665878