An Investigation on Adherence of Cryptococcus neoformans Serotypes (A, B, C and D) in Rat Lung Cell Culture

Şinasi Taner YILDIRAN

Makale detayları

An Investigation on Adherence of Cryptococcus neoformans Serotypes (A, B, C and D) in Rat Lung Cell Culture

Yazarlar:

Şinasi Taner YILDIRAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 1, pp.13-18

Belge Tipi:

Makale

Yayın Tarihi:

12/1997

Belge Dili:

İngilizce

Document ID (Org No.):

2000758482

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Cryptococcus neoformans causes  an opportunistic infection known as cryptococcosis  principally in immunocompromised  individuals. It is not clearly known whether  the serotype of the infecting strain of Cryptococcus  neoformans has its own properties  related to its adherence to host tissues in disease  process. Here, the adherence of each  serotype (A, B, C, and D) was investigated using  primary rat lung cell culture in a timedependent  manner. After the confluent monolayer  of primary rat lung cell culture was  obtained, the adherence assay was performed.  The mean binding index (Bl) value of  serotype D was statistically significant(p0.05).  These findings suggest that the adherence of  each serotype may not be increased in a timedependent  manner, but the adherence of ser-otype  D seems to be significantly increased at  early time period (at second vs. fourth hour).

 

Cryptococcus neoformans causes  an opportunistic infection known as cryptococcosis  principally in immunocompromised  individuals. It is not clearly known whether  the serotype of the infecting strain of Cryptococcus  neoformans has its own properties  related to its adherence to host tissues in disease  process. Here, the adherence of each  serotype (A, B, C, and D) was investigated using  primary rat lung cell culture in a timedependent  manner. After the confluent monolayer  of primary rat lung cell culture was  obtained, the adherence assay was performed.  The mean binding index (Bl) value of  serotype D was statistically significant(p0.05).  These findings suggest that the adherence of  each serotype may not be increased in a timedependent  manner, but the adherence of ser-otype  D seems to be significantly increased at  early time period (at second vs. fourth hour).

Makale detayları

An Investigation on Adherence of Cryptococcus neoformans Serotypes (A, B, C and D) in Rat Lung Cell Culture

Yazarlar:

Şinasi Taner YILDIRAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 1, pp.13-18

Belge Tipi:

Makale

Yayın Tarihi:

12/1997

Belge Dili:

İngilizce

Document ID (Org No.):

2000758482

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Cryptococcus neoformans

serotype

adherence

cell culture.

Sayı

Makale detayları

An Investigation on Adherence of Cryptococcus neoformans Serotypes (A, B, C and D) in Rat Lung Cell Culture

Yazarlar: Şinasi Taner YILDIRAN

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 1998 Vol.28 Issue 1, pp.13-18

Belge Tipi: Makale

Yayın Tarihi: 12/1997

Belge Dili: İngilizce

Document ID (Org No.): 2000758482

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Cryptococcus neoformans

serotype

adherence

cell culture.

Sayı

Yazarlar:

Şinasi Taner YILDIRAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 1, pp.13-18

Belge Tipi:

Makale

Yayın Tarihi:

12/1997

Belge Dili:

İngilizce

Document ID (Org No.):

2000758482

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144