Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Etil Güzelmeriç; Hasan Kırmızıbekmez

Makale detayları

Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Yazarlar:

Etil Güzelmeriç | Hasan Kırmızıbekmez

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 1, pp.79-88

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345983

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Two secoiridoid glycosides, lonicejaposide I 1 and secologanin dimethyl acetal 2, six flavonoids, isoorientin 3 hesperidin 4, apigenin 7-O-neohesperidoside 5, luteolin 7-O-b-D-glucopyranoside 6, kaempferol 3- O-3,6-di-E-p-coumaroyl-b-D-glucopyranoside 7, and kaempferol 3-O-3-O-acetyl, 6-O-E-p-coumaroyl-b-Dglycopyranoside 8, two caffeoylquinic acid derivatives, chlorogenic acid 9 and 3,5-dicaffeoylquinic acid 10 were isolated from the EtOAc and H2O subextracts of the crude MeOH extract prepared from the aerial parts of Scabiosa atropurpurea. Their structures were identified by extensive 1D and 2D NMR experiments as well as ESI-MS analysis. Xanthine oxidase XO inhibitory and antioxidant activities of the isolated compounds were evaluated by in vitro tests. Compounds, 3, 5, 6, 9 and 10 showed mild-to-moderate inhibitory effects on XO enzyme. The highest antioxidant activity was found for compound 10 according to results of DPPH, FRAP and CUPRAC assays. This is the first study on the XO inhibitory activities for compounds 1, 2, 5, 7 and 8.

 Two secoiridoid glycosides, lonicejaposide I 1 and secologanin dimethyl acetal 2, six flavonoids, isoorientin 3 hesperidin 4, apigenin 7-O-neohesperidoside 5, luteolin 7-O-b-D-glucopyranoside 6, kaempferol 3- O-3,6-di-E-p-coumaroyl-b-D-glucopyranoside 7, and kaempferol 3-O-3-O-acetyl, 6-O-E-p-coumaroyl-b-Dglycopyranoside 8, two caffeoylquinic acid derivatives, chlorogenic acid 9 and 3,5-dicaffeoylquinic acid 10 were isolated from the EtOAc and H2O subextracts of the crude MeOH extract prepared from the aerial parts of Scabiosa atropurpurea. Their structures were identified by extensive 1D and 2D NMR experiments as well as ESI-MS analysis. Xanthine oxidase XO inhibitory and antioxidant activities of the isolated compounds were evaluated by in vitro tests. Compounds, 3, 5, 6, 9 and 10 showed mild-to-moderate inhibitory effects on XO enzyme. The highest antioxidant activity was found for compound 10 according to results of DPPH, FRAP and CUPRAC assays. This is the first study on the XO inhibitory activities for compounds 1, 2, 5, 7 and 8.

 Two secoiridoid glycosides, lonicejaposide I 1 and secologanin dimethyl acetal 2, six flavonoids, isoorientin 3 hesperidin 4, apigenin 7-O-neohesperidoside 5, luteolin 7-O-b-D-glucopyranoside 6, kaempferol 3- O-3,6-di-E-p-coumaroyl-b-D-glucopyranoside 7, and kaempferol 3-O-3-O-acetyl, 6-O-E-p-coumaroyl-b-Dglycopyranoside 8, two caffeoylquinic acid derivatives, chlorogenic acid 9 and 3,5-dicaffeoylquinic acid 10 were isolated from the EtOAc and H2O subextracts of the crude MeOH extract prepared from the aerial parts of Scabiosa atropurpurea. Their structures were identified by extensive 1D and 2D NMR experiments as well as ESI-MS analysis. Xanthine oxidase XO inhibitory and antioxidant activities of the isolated compounds were evaluated by in vitro tests. Compounds, 3, 5, 6, 9 and 10 showed mild-to-moderate inhibitory effects on XO enzyme. The highest antioxidant activity was found for compound 10 according to results of DPPH, FRAP and CUPRAC assays. This is the first study on the XO inhibitory activities for compounds 1, 2, 5, 7 and 8.

 Two secoiridoid glycosides, lonicejaposide I 1 and secologanin dimethyl acetal 2, six flavonoids, isoorientin 3 hesperidin 4, apigenin 7-O-neohesperidoside 5, luteolin 7-O-b-D-glucopyranoside 6, kaempferol 3- O-3,6-di-E-p-coumaroyl-b-D-glucopyranoside 7, and kaempferol 3-O-3-O-acetyl, 6-O-E-p-coumaroyl-b-Dglycopyranoside 8, two caffeoylquinic acid derivatives, chlorogenic acid 9 and 3,5-dicaffeoylquinic acid 10 were isolated from the EtOAc and H2O subextracts of the crude MeOH extract prepared from the aerial parts of Scabiosa atropurpurea. Their structures were identified by extensive 1D and 2D NMR experiments as well as ESI-MS analysis. Xanthine oxidase XO inhibitory and antioxidant activities of the isolated compounds were evaluated by in vitro tests. Compounds, 3, 5, 6, 9 and 10 showed mild-to-moderate inhibitory effects on XO enzyme. The highest antioxidant activity was found for compound 10 according to results of DPPH, FRAP and CUPRAC assays. This is the first study on the XO inhibitory activities for compounds 1, 2, 5, 7 and 8.

Makale detayları

Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Yazarlar:

Etil Güzelmeriç | Hasan Kırmızıbekmez

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 1, pp.79-88

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345983

pISSN:

2630-6344

Scabiosa atropurpurea

secoiridoids

flavonoids

caffeoylquinic acid derivatives

xanthine oxidase inhibitory activity; antioxidant activity

Sayı

Makale detayları

Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Yazarlar: Etil Güzelmeriç | Hasan Kırmızıbekmez

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.28 Issue 1, pp.79-88

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001345983

pISSN: 2630-6344

Scabiosa atropurpurea

secoiridoids

flavonoids

caffeoylquinic acid derivatives

xanthine oxidase inhibitory activity; antioxidant activity

Sayı

Yazarlar:

Etil Güzelmeriç | Hasan Kırmızıbekmez

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 1, pp.79-88

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345983

pISSN:

2630-6344