Wilms tumor with intravascular extension: Analyzing tumor thrombus characteristics and survival

Kıvılcım Cerit Karadeniz; Nurşah Eker; Dilek Gül; Elif Demirbaş; Özge Yapıcı

Makale detayları

Wilms tumor with intravascular extension: Analyzing tumor thrombus characteristics and survival

Yazarlar:

Kıvılcım Cerit Karadeniz | Nurşah Eker | Dilek Gül | Elif Demirbaş | Özge Yapıcı

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.38 Issue 2, pp.114-120

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340969

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: The aim of the study is to review the oncological and surgical strategies for Wilms tumor WT with intravascular thrombus extension at our institution. Patients and Methods: Medical records of patients with WT treated in our institution between June 2012 and June 2024 were retrospectively reviewed. Among these data, patients with intravascular tumor thrombus were identified. Demographics, imaging studies to determine the initial level of thrombus, surgical management and outcomes were analyzed. Results: During this period 51 patients with WT were treated in our institution. Seven patients 6 male, 1 female with intravascular tumor thrombus extension were identified 13. The median age was 46 months 22-67 months. Six patients had unilateral WT UWT and one patient had bilateral WT BWT. Tumor thrombus extension during initial evaluation were: level III 5, level IV 1 and level V 1. Thrombus level in all patients with level III regressed to level II, while, no regression was observed in 2 patients with cardiac thrombus. All patients underwent surgery after neoadjuvant chemotherapy. At a median follow-up of 5 years, the 5-year eventfree survival and overall survival rates were 83.3 and 83.3 respectively in patients with intravascular thrombus. In addition, the 5-year event-free survival and overall survival rates were 85 and 94 respectively in patients without intravascular thrombus. Conclusion: Management of WT with intravascular thrombus is a challenging process. Multidisciplinary approach and an experienced surgical team are the main factors that determine survival in these patients.

 Objective: The aim of the study is to review the oncological and surgical strategies for Wilms tumor WT with intravascular thrombus extension at our institution. Patients and Methods: Medical records of patients with WT treated in our institution between June 2012 and June 2024 were retrospectively reviewed. Among these data, patients with intravascular tumor thrombus were identified. Demographics, imaging studies to determine the initial level of thrombus, surgical management and outcomes were analyzed. Results: During this period 51 patients with WT were treated in our institution. Seven patients 6 male, 1 female with intravascular tumor thrombus extension were identified 13. The median age was 46 months 22-67 months. Six patients had unilateral WT UWT and one patient had bilateral WT BWT. Tumor thrombus extension during initial evaluation were: level III 5, level IV 1 and level V 1. Thrombus level in all patients with level III regressed to level II, while, no regression was observed in 2 patients with cardiac thrombus. All patients underwent surgery after neoadjuvant chemotherapy. At a median follow-up of 5 years, the 5-year eventfree survival and overall survival rates were 83.3 and 83.3 respectively in patients with intravascular thrombus. In addition, the 5-year event-free survival and overall survival rates were 85 and 94 respectively in patients without intravascular thrombus. Conclusion: Management of WT with intravascular thrombus is a challenging process. Multidisciplinary approach and an experienced surgical team are the main factors that determine survival in these patients.

 Objective: The aim of the study is to review the oncological and surgical strategies for Wilms tumor WT with intravascular thrombus extension at our institution. Patients and Methods: Medical records of patients with WT treated in our institution between June 2012 and June 2024 were retrospectively reviewed. Among these data, patients with intravascular tumor thrombus were identified. Demographics, imaging studies to determine the initial level of thrombus, surgical management and outcomes were analyzed. Results: During this period 51 patients with WT were treated in our institution. Seven patients 6 male, 1 female with intravascular tumor thrombus extension were identified 13. The median age was 46 months 22-67 months. Six patients had unilateral WT UWT and one patient had bilateral WT BWT. Tumor thrombus extension during initial evaluation were: level III 5, level IV 1 and level V 1. Thrombus level in all patients with level III regressed to level II, while, no regression was observed in 2 patients with cardiac thrombus. All patients underwent surgery after neoadjuvant chemotherapy. At a median follow-up of 5 years, the 5-year eventfree survival and overall survival rates were 83.3 and 83.3 respectively in patients with intravascular thrombus. In addition, the 5-year event-free survival and overall survival rates were 85 and 94 respectively in patients without intravascular thrombus. Conclusion: Management of WT with intravascular thrombus is a challenging process. Multidisciplinary approach and an experienced surgical team are the main factors that determine survival in these patients.

 Objective: The aim of the study is to review the oncological and surgical strategies for Wilms tumor WT with intravascular thrombus extension at our institution. Patients and Methods: Medical records of patients with WT treated in our institution between June 2012 and June 2024 were retrospectively reviewed. Among these data, patients with intravascular tumor thrombus were identified. Demographics, imaging studies to determine the initial level of thrombus, surgical management and outcomes were analyzed. Results: During this period 51 patients with WT were treated in our institution. Seven patients 6 male, 1 female with intravascular tumor thrombus extension were identified 13. The median age was 46 months 22-67 months. Six patients had unilateral WT UWT and one patient had bilateral WT BWT. Tumor thrombus extension during initial evaluation were: level III 5, level IV 1 and level V 1. Thrombus level in all patients with level III regressed to level II, while, no regression was observed in 2 patients with cardiac thrombus. All patients underwent surgery after neoadjuvant chemotherapy. At a median follow-up of 5 years, the 5-year eventfree survival and overall survival rates were 83.3 and 83.3 respectively in patients with intravascular thrombus. In addition, the 5-year event-free survival and overall survival rates were 85 and 94 respectively in patients without intravascular thrombus. Conclusion: Management of WT with intravascular thrombus is a challenging process. Multidisciplinary approach and an experienced surgical team are the main factors that determine survival in these patients.

Makale detayları

Wilms tumor with intravascular extension: Analyzing tumor thrombus characteristics and survival

Yazarlar:

Kıvılcım Cerit Karadeniz | Nurşah Eker | Dilek Gül | Elif Demirbaş | Özge Yapıcı

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.38 Issue 2, pp.114-120

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340969

pISSN:

1019-1941

Wilms tumor

Intravascular extension

Children

Sayı

Makale detayları

Wilms tumor with intravascular extension: Analyzing tumor thrombus characteristics and survival

Yazarlar: Kıvılcım Cerit Karadeniz | Nurşah Eker | Dilek Gül | Elif Demirbaş | Özge Yapıcı

Yayıncı: Marmara University

Ana Başlıklar: Surgery (Other)

Dergi: Marmara Medical Journal Vol.38 Issue 2, pp.114-120

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001340969

pISSN: 1019-1941

Wilms tumor

Intravascular extension

Children

Sayı

Yazarlar:

Kıvılcım Cerit Karadeniz | Nurşah Eker | Dilek Gül | Elif Demirbaş | Özge Yapıcı

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.38 Issue 2, pp.114-120

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340969

pISSN:

1019-1941