Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack

Erkan Boğa

Makale detayları

Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack

Yazarlar:

Erkan Boğa

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Acil Tıp | Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 1, pp.7-12

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341141

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Abstract Aims: The primary aim of this study is to investigate the potential role of mean platelet volume MPV in the diagnostic and prognostic evaluation of acute ischemic stroke AIS and transient ischemic attack TIA, focusing on its clinical significance and role in diagnostic processes. This study aims to evaluate the clinical significance of MPV in patients with AIS and TIA and its role in diagnostic processes. Methods: This retrospective study was conducted between June 15 and December 15, 2014, at the Emergency Medicine Department of Haydarpaşa Numune Training and Research Hospital. The study included 300 patients diagnosed with AIS or TIA and 100 healthy individuals matched for demographic characteristics as the control group. Participants were evaluated based on vascular risk factors such as hypertension, diabetes, and hyperlipidemia, and AIS subgroups were analyzed according to the TOAST classification. MPV and platelet counts, along with biochemical parameters, were measured, and statistical analyses were performed utilizing SPSS software. Results: MPV values in the case group were significantly higher compared to the control group p0.001. No significant differences were observed in platelet counts between the two groups p0.05. MPV demonstrated no significant associations with hypertension, hyperlipidemia, or other vascular risk factors; however, patients with a history of TIA exhibited higher MPV levels compared to those without, although the difference was not statistically significant. A weak but statistically significant negative correlation was identified between MPV and platelet counts r-0.20, p0.05. Conclusion: MPV demonstrates potential as a significant biomarker in the diagnostic and prognostic processes of AIS and TIA. Nevertheless, the inconsistencies observed in the literature regarding the relationship between MPV and risk factors necessitate more extensive, prospective, and standardized studies to elucidate its clinical utility. The evidence suggests that MPV may contribute to enhancing diagnostic accuracy in clinical practice.

 Abstract Aims: The primary aim of this study is to investigate the potential role of mean platelet volume MPV in the diagnostic and prognostic evaluation of acute ischemic stroke AIS and transient ischemic attack TIA, focusing on its clinical significance and role in diagnostic processes. This study aims to evaluate the clinical significance of MPV in patients with AIS and TIA and its role in diagnostic processes. Methods: This retrospective study was conducted between June 15 and December 15, 2014, at the Emergency Medicine Department of Haydarpaşa Numune Training and Research Hospital. The study included 300 patients diagnosed with AIS or TIA and 100 healthy individuals matched for demographic characteristics as the control group. Participants were evaluated based on vascular risk factors such as hypertension, diabetes, and hyperlipidemia, and AIS subgroups were analyzed according to the TOAST classification. MPV and platelet counts, along with biochemical parameters, were measured, and statistical analyses were performed utilizing SPSS software. Results: MPV values in the case group were significantly higher compared to the control group p0.001. No significant differences were observed in platelet counts between the two groups p0.05. MPV demonstrated no significant associations with hypertension, hyperlipidemia, or other vascular risk factors; however, patients with a history of TIA exhibited higher MPV levels compared to those without, although the difference was not statistically significant. A weak but statistically significant negative correlation was identified between MPV and platelet counts r-0.20, p0.05. Conclusion: MPV demonstrates potential as a significant biomarker in the diagnostic and prognostic processes of AIS and TIA. Nevertheless, the inconsistencies observed in the literature regarding the relationship between MPV and risk factors necessitate more extensive, prospective, and standardized studies to elucidate its clinical utility. The evidence suggests that MPV may contribute to enhancing diagnostic accuracy in clinical practice.

 Abstract Aims: The primary aim of this study is to investigate the potential role of mean platelet volume MPV in the diagnostic and prognostic evaluation of acute ischemic stroke AIS and transient ischemic attack TIA, focusing on its clinical significance and role in diagnostic processes. This study aims to evaluate the clinical significance of MPV in patients with AIS and TIA and its role in diagnostic processes. Methods: This retrospective study was conducted between June 15 and December 15, 2014, at the Emergency Medicine Department of Haydarpaşa Numune Training and Research Hospital. The study included 300 patients diagnosed with AIS or TIA and 100 healthy individuals matched for demographic characteristics as the control group. Participants were evaluated based on vascular risk factors such as hypertension, diabetes, and hyperlipidemia, and AIS subgroups were analyzed according to the TOAST classification. MPV and platelet counts, along with biochemical parameters, were measured, and statistical analyses were performed utilizing SPSS software. Results: MPV values in the case group were significantly higher compared to the control group p0.001. No significant differences were observed in platelet counts between the two groups p0.05. MPV demonstrated no significant associations with hypertension, hyperlipidemia, or other vascular risk factors; however, patients with a history of TIA exhibited higher MPV levels compared to those without, although the difference was not statistically significant. A weak but statistically significant negative correlation was identified between MPV and platelet counts r-0.20, p0.05. Conclusion: MPV demonstrates potential as a significant biomarker in the diagnostic and prognostic processes of AIS and TIA. Nevertheless, the inconsistencies observed in the literature regarding the relationship between MPV and risk factors necessitate more extensive, prospective, and standardized studies to elucidate its clinical utility. The evidence suggests that MPV may contribute to enhancing diagnostic accuracy in clinical practice.

 Özet Amaç: Bu çalışmanın temel amacı, ortalama trombosit hacminin MPV akut iskemik inme AIS ve geçici iskemik atağın TIA tanı ve prognostik değerlendirmesindeki potansiyel rolünü araştırmaktır. Çalışma, AIS ve TIA hastalarında MPVnin klinik önemini değerlendirmeyi ve tanı süreçlerine katkısını incelemeyi hedeflemiştir. Yöntemler: Bu retrospektif çalışma, 15 Haziran - 15 Aralık 2014 tarihleri arasında Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Acil Tıp Kliniğinde gerçekleştirilmiştir. Çalışmaya AIS veya TIA tanısı almış 300 hasta ile demografik olarak eşleştirilmiş 100 sağlıklı bireyden oluşan bir kontrol grubu dahil edilmiştir. Katılımcılar, hipertansiyon, diyabet ve hiperlipidemi gibi vasküler risk faktörlerine göre değerlendirilmiş ve AIS alt grupları TOAST sınıflamasına göre analiz edilmiştir. MPV ve trombosit sayıları ile birlikte biyokimyasal parametreler ölçülmüş ve istatistiksel analizler SPSS yazılımı kullanılarak gerçekleştirilmiştir. Bulgular: Olgu grubundaki MPV değerleri, kontrol grubuna kıyasla anlamlı derecede yüksek bulunmuştur p0.001. Trombosit sayıları açısından gruplar arasında anlamlı bir fark saptanmamıştır p0.05. MPV, hipertansiyon, hiperlipidemi ve diğer vasküler risk faktörleriyle anlamlı bir ilişki göstermemiştir; ancak TIA öyküsü olan hastalarda MPVnin daha yüksek olduğu gözlenmiştir, bu fark istatistiksel olarak anlamlı değildir. MPV ile trombosit sayıları arasında zayıf, ancak istatistiksel olarak anlamlı bir negatif korelasyon tespit edilmiştir r-0.20, p0.05. Sonuç: Ortalama trombosit hacmi, AIS ve TIAnın tanı ve prognostik süreçlerinde önemli bir biyobelirteç olarak kullanılma potansiyeline sahiptir. Ancak, MPV ile risk faktörleri arasındaki ilişkiye dair literatürde gözlenen tutarsızlıklar, bu parametrenin klinik uygulamalardaki yerini netleştirmek için daha kapsamlı, prospektif ve standartlaştırılmış çalışmaları gerekli kılmaktadır. Bulgular, MPVnin klinik uygulamalarda tanısal doğruluğun artırılmasına katkı sağlayabileceğini düşündürmektedir. Anahtar Kelimeler: Akut iskemik inme, geçici iskemik atak, ortalama trombosit hacmi, biyobelirteç, serebrovasküler hastalık.

Makale detayları

Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack

Yazarlar:

Erkan Boğa

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Acil Tıp | Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 1, pp.7-12

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341141

pISSN:

2717-7505

Acute ischemic stroke

transient ischemic attack

mean platelet volume

biomarker

cerebrovascular diseaseAnahtar Kelimeler: Akut iskemik inme

geçici iskemik atak

ortalama trombosit hacmi

biyobelirteç

serebrovasküler hastalık.

Sayı

Makale detayları

Yazarlar: Erkan Boğa

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Acil Tıp | Nöroloji ve Nöromüsküler Hastalıklar

Dergi: Journal of Medicine and Palliative Care Vol.6 Issue 1, pp.7-12

Belge Tipi: Makale

Yayın Tarihi: 2/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341141

pISSN: 2717-7505

Sayı

Yazarlar:

Erkan Boğa

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Acil Tıp | Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 1, pp.7-12

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341141

pISSN:

2717-7505