Production of Polymeric Nanofiber Membranes Containing Plant Extract and Investigation of Their Potential for Use on Wound Healing

Zeliha Esra Çakmak; Nergis Zeynep Renkler

Makale detayları

Production of Polymeric Nanofiber Membranes Containing Plant Extract and Investigation of Their Potential for Use on Wound Healing

Yazarlar:

Zeliha Esra Çakmak | Nergis Zeynep Renkler

Yayıncı:

Hacettepe University

Ana Başlıklar:

Sensor Technology

Dergi:

Hacettepe Journal of Biology and Chemistry Vol.52 Issue 6, pp.425-437

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319453

pISSN:

2687-475X

Anahtar kelimeler:

Özet:

 In cases of injury to the skin tissue, such as severe burns, these layers can be extensively damaged. A variety of dressings have been developed to address different types of wounds, with functional polymeric dressings being among the most popular. These advanced dressings are designed to accelerate the wound-healing process. The incorporation of plant-derived extracts and biological molecules into wound dressing materials is a common practice. This study aimed to develop an electrospun nanofiber wound dressing by incorporating active ingredients extracted from the plant Echium italicum Italian vipers bugloss, known for its efficacy in burn wound healing, into polylactic-co-glycolic acid PLGA. The nanofiber membrane wound dressings produced by electrospinning were subjected to various analyses. Morphological and structural characterization revealed that the membranes exhibited significant morphological decomposition and weight loss after 90 days of in vitro degradation under physiological conditions. In vitro cytotoxicity testing, conducted using the MEM extraction method, demonstrated that the membranes were not cytotoxic. Based on the comprehensive analysis, it was concluded that the developed nanofiber membranes hold promise as potential wound dressings for the treatment of severe burn wounds.

 In cases of injury to the skin tissue, such as severe burns, these layers can be extensively damaged. A variety of dressings have been developed to address different types of wounds, with functional polymeric dressings being among the most popular. These advanced dressings are designed to accelerate the wound-healing process. The incorporation of plant-derived extracts and biological molecules into wound dressing materials is a common practice. This study aimed to develop an electrospun nanofiber wound dressing by incorporating active ingredients extracted from the plant Echium italicum Italian vipers bugloss, known for its efficacy in burn wound healing, into polylactic-co-glycolic acid PLGA. The nanofiber membrane wound dressings produced by electrospinning were subjected to various analyses. Morphological and structural characterization revealed that the membranes exhibited significant morphological decomposition and weight loss after 90 days of in vitro degradation under physiological conditions. In vitro cytotoxicity testing, conducted using the MEM extraction method, demonstrated that the membranes were not cytotoxic. Based on the comprehensive analysis, it was concluded that the developed nanofiber membranes hold promise as potential wound dressings for the treatment of severe burn wounds.

 In cases of injury to the skin tissue, such as severe burns, these layers can be extensively damaged. A variety of dressings have been developed to address different types of wounds, with functional polymeric dressings being among the most popular. These advanced dressings are designed to accelerate the wound-healing process. The incorporation of plant-derived extracts and biological molecules into wound dressing materials is a common practice. This study aimed to develop an electrospun nanofiber wound dressing by incorporating active ingredients extracted from the plant Echium italicum Italian vipers bugloss, known for its efficacy in burn wound healing, into polylactic-co-glycolic acid PLGA. The nanofiber membrane wound dressings produced by electrospinning were subjected to various analyses. Morphological and structural characterization revealed that the membranes exhibited significant morphological decomposition and weight loss after 90 days of in vitro degradation under physiological conditions. In vitro cytotoxicity testing, conducted using the MEM extraction method, demonstrated that the membranes were not cytotoxic. Based on the comprehensive analysis, it was concluded that the developed nanofiber membranes hold promise as potential wound dressings for the treatment of severe burn wounds.

 Cilt dokusunda ciddi yanıklar gibi yaralanmalar olduğunda, bu katmanlar büyük ölçüde hasar görebilir. Farklı yara tiplerini ele almak için çeşitli yara örtüleri geliştirilmiştir ve bunların arasında en popüler olanı fonksiyonel polimerik yara örtüleridir. Bitkisel özlerin ve biyolojik moleküllerin yara örtü malzemelerine dahil edilmesi yaygın bir uygulamadır. Bu çalışma, yanık yarası iyileşmesinde etkinliği bilinen Echium italicum bitkisinden elde edilen aktif bileşenler ile polilaktik-ko-glikolik asit PLGA polimeri blend edilerek elektroeğirme yoluyla üretilen nanofiber yara örtü malzemesi geliştirmeyi amaçlamaktadır. Elektroeğirme yoluyla üretilen nanofiber membranlı yara örtü malzemeleri çeşitli analizlere tabi tutulmuştur. Morfolojik ve yapısal karakterizasyon, membranların fizyolojik koşullar altında 90 günlük in vitro bozunma sonrasında önemli morfolojik ayrışma ve ağırlık kaybı sergilediğini ortaya koymuştur. MEM ekstraksiyon yöntemi kullanılarak yürütülen in vitro sitotoksisite testi, membranların sitotoksik olmadığını göstermiştir. Kapsamlı analize dayanarak, geliştirilen nanofiber membranların ciddi yanık yaralarının tedavisi için potansiyel yara örtü malzemeleri olarak umut vadettiği sonucuna varılmıştır.

Makale detayları

Production of Polymeric Nanofiber Membranes Containing Plant Extract and Investigation of Their Potential for Use on Wound Healing

Yazarlar:

Zeliha Esra Çakmak | Nergis Zeynep Renkler

Yayıncı:

Hacettepe University

Ana Başlıklar:

Sensor Technology

Dergi:

Hacettepe Journal of Biology and Chemistry Vol.52 Issue 6, pp.425-437

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319453

pISSN:

2687-475X

Polymeric wound dressing

Echium italicum

poly (lactic-co-glycolic acid)

electrospinningPolimerik yara örtüsü

Echium italicum

poli (laktik-ko-glikolik asit)

elektroeğirme

Sayı

Makale detayları

Yazarlar: Zeliha Esra Çakmak | Nergis Zeynep Renkler

Yayıncı: Hacettepe University

Ana Başlıklar: Sensor Technology

Dergi: Hacettepe Journal of Biology and Chemistry Vol.52 Issue 6, pp.425-437

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001319453

pISSN: 2687-475X

Sayı

Yazarlar:

Zeliha Esra Çakmak | Nergis Zeynep Renkler

Yayıncı:

Hacettepe University

Ana Başlıklar:

Sensor Technology

Dergi:

Hacettepe Journal of Biology and Chemistry Vol.52 Issue 6, pp.425-437

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319453

pISSN:

2687-475X