Long-term monitoring of Graves' disease in children and adolescents: a single-center experience

Selma TUNÇ; Özge KÖPRÜLÜ; Hatice ORTAÇ; Özlem NALBANTOĞLU; Ceyhun DİZDARER; Korcan DEMİR; Behzat ÖZKAN

Makale detayları

Long-term monitoring of Graves' disease in children and adolescents: a single-center experience

Yazarlar:

Selma TUNÇ | Özge KÖPRÜLÜ | Hatice ORTAÇ | Özlem NALBANTOĞLU | Ceyhun DİZDARER | Korcan DEMİR | Behzat ÖZKAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.464-471

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750156

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Graves' disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or  radioactive  iodine  (RAI)  treatments  are  not  definitive  and  generally  result  in  permanent  hypothyroidism.This  study's  goal  was  examining the effectiveness of ATD treatment in children and adolescents withGD and determining the risk factors of remission and relapse.Materials and methods: This retrospective study included 45 patients (36 females and 9 males, median age 12.5 years) aged 4-18 who were diagnosed with GD between 2003 and 2017. All patients initially were treated with an ATD. ATD treatment was discontinued at a mean of 23.2 ± 13.2 months (10-37 months). Results:  Patients  were  classified  into  remission  (n  =  24)  and  relapse  groups  (n  =  21).  The  duration  of  initial  ATD  treatment  in  the  remission group was longer (26.91 ± 5.17 months) than in the relapse group (19.09 ± 7.14 months) (P = 0.01). The total ATD treatment duration was statistically longer in the remission group (42.14 ± 14.35 months) than in the relapse group (26.95 ± 16.13 months) (P = 0.03). Conclusion:  Long-term  initial  ATD  treatment  and  long-term  total  ATD  treatment  were  evaluated  as  positive  parameters  for  the  remission of Graves' disease in children and adolescents. Our findings showed that the chance of long-term remission increases in direct proportion to the initial ATD treatment duration and the total ATD treatment duration.

Makale detayları

Long-term monitoring of Graves' disease in children and adolescents: a single-center experience

Yazarlar: Selma TUNÇ | Özge KÖPRÜLÜ | Hatice ORTAÇ | Özlem NALBANTOĞLU | Ceyhun DİZDARER | Korcan DEMİR | Behzat ÖZKAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.464-471

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750156

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Selma TUNÇ | Özge KÖPRÜLÜ | Hatice ORTAÇ | Özlem NALBANTOĞLU | Ceyhun DİZDARER | Korcan DEMİR | Behzat ÖZKAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.464-471

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750156

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144