Single-Center Experience and Literature Review of Radiotherapy Outcomes for Adult Ependymomas

Ayşegül Üçüncü Kefeli; Büşra Yaprak Bayrak; Maksut Görkem Aksu

Makale detayları

Single-Center Experience and Literature Review of Radiotherapy Outcomes for Adult Ependymomas

Yazarlar:

Ayşegül Üçüncü Kefeli | Büşra Yaprak Bayrak | Maksut Görkem Aksu

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 2, pp.53-61

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326661

pISSN:

2149-8571

Anahtar kelimeler:

Özet:

 Objective: To retrospectively determine the long-term outcome of adult intracranial and spinal ependymoma patients treated with postoperative radiation therapy after surgery. Methods: Fourteen adult patients who underwent radiotherapy after surgery at a single center between 1999 and 2022 were included. The endpoints analyzed were overall survival and progression-free survival, together with prognostic factors. Results: The median range age was 29.5 2358 years. The majority 71.4 of the tumors were located in the spinal canal and gross total resection was performed in nine 64.3 patients. Six patients were irradiated after recurrence spinal n4, intracranial n2 of whom three had myxopapillary and two had anaplastic histology. Patients were followed up for a median duration of 106.5 13-172 months. Overall, 4 patients intracranial n3, spinal n1 had recurrences and died after radiotherapy as a direct result of disease progression during the follow-up period. All of these intracranial tumors exhibited anaplastic histology and the spinal tumor was myxopapillary type. Patients with intracranial lesions had a 5-year survival of 50 and no patient was alive on the 10th year, compared with 5- and 10-year overall survival of 87.5  for patients with spinal tumors. Patients with spinal tumors had a 5- and 10-year progression-free survival rate of 52.5, while those with intracranial lesions had a rate of 25. Conclusion: In low-grade spinal ependymomas radiotherapy appears to control disease, even after recurrence. For myxopapillary ependymoma patients, in subtotally resected intracranial and all high-grade tumors, regardless of the extent of resection, adjuvant radiotherapy should be administered.

 Objective: To retrospectively determine the long-term outcome of adult intracranial and spinal ependymoma patients treated with postoperative radiation therapy after surgery. Methods: Fourteen adult patients who underwent radiotherapy after surgery at a single center between 1999 and 2022 were included. The endpoints analyzed were overall survival and progression-free survival, together with prognostic factors. Results: The median range age was 29.5 2358 years. The majority 71.4 of the tumors were located in the spinal canal and gross total resection was performed in nine 64.3 patients. Six patients were irradiated after recurrence spinal n4, intracranial n2 of whom three had myxopapillary and two had anaplastic histology. Patients were followed up for a median duration of 106.5 13-172 months. Overall, 4 patients intracranial n3, spinal n1 had recurrences and died after radiotherapy as a direct result of disease progression during the follow-up period. All of these intracranial tumors exhibited anaplastic histology and the spinal tumor was myxopapillary type. Patients with intracranial lesions had a 5-year survival of 50 and no patient was alive on the 10th year, compared with 5- and 10-year overall survival of 87.5  for patients with spinal tumors. Patients with spinal tumors had a 5- and 10-year progression-free survival rate of 52.5, while those with intracranial lesions had a rate of 25. Conclusion: In low-grade spinal ependymomas radiotherapy appears to control disease, even after recurrence. For myxopapillary ependymoma patients, in subtotally resected intracranial and all high-grade tumors, regardless of the extent of resection, adjuvant radiotherapy should be administered.

 Objective: To retrospectively determine the long-term outcome of adult intracranial and spinal ependymoma patients treated with postoperative radiation therapy after surgery. Methods: Fourteen adult patients who underwent radiotherapy after surgery at a single center between 1999 and 2022 were included. The endpoints analyzed were overall survival and progression-free survival, together with prognostic factors. Results: The median range age was 29.5 2358 years. The majority 71.4 of the tumors were located in the spinal canal and gross total resection was performed in nine 64.3 patients. Six patients were irradiated after recurrence spinal n4, intracranial n2 of whom three had myxopapillary and two had anaplastic histology. Patients were followed up for a median duration of 106.5 13-172 months. Overall, 4 patients intracranial n3, spinal n1 had recurrences and died after radiotherapy as a direct result of disease progression during the follow-up period. All of these intracranial tumors exhibited anaplastic histology and the spinal tumor was myxopapillary type. Patients with intracranial lesions had a 5-year survival of 50 and no patient was alive on the 10th year, compared with 5- and 10-year overall survival of 87.5  for patients with spinal tumors. Patients with spinal tumors had a 5- and 10-year progression-free survival rate of 52.5, while those with intracranial lesions had a rate of 25. Conclusion: In low-grade spinal ependymomas radiotherapy appears to control disease, even after recurrence. For myxopapillary ependymoma patients, in subtotally resected intracranial and all high-grade tumors, regardless of the extent of resection, adjuvant radiotherapy should be administered.

 Objective: To retrospectively determine the long-term outcome of adult intracranial and spinal ependymoma patients treated with postoperative radiation therapy after surgery. Methods: Fourteen adult patients who underwent radiotherapy after surgery at a single center between 1999 and 2022 were included. The endpoints analyzed were overall survival and progression-free survival, together with prognostic factors. Results: The median range age was 29.5 2358 years. The majority 71.4 of the tumors were located in the spinal canal and gross total resection was performed in nine 64.3 patients. Six patients were irradiated after recurrence spinal n4, intracranial n2 of whom three had myxopapillary and two had anaplastic histology. Patients were followed up for a median duration of 106.5 13-172 months. Overall, 4 patients intracranial n3, spinal n1 had recurrences and died after radiotherapy as a direct result of disease progression during the follow-up period. All of these intracranial tumors exhibited anaplastic histology and the spinal tumor was myxopapillary type. Patients with intracranial lesions had a 5-year survival of 50 and no patient was alive on the 10th year, compared with 5- and 10-year overall survival of 87.5  for patients with spinal tumors. Patients with spinal tumors had a 5- and 10-year progression-free survival rate of 52.5, while those with intracranial lesions had a rate of 25. Conclusion: In low-grade spinal ependymomas radiotherapy appears to control disease, even after recurrence. For myxopapillary ependymoma patients, in subtotally resected intracranial and all high-grade tumors, regardless of the extent of resection, adjuvant radiotherapy should be administered.

Makale detayları

Single-Center Experience and Literature Review of Radiotherapy Outcomes for Adult Ependymomas

Yazarlar: Ayşegül Üçüncü Kefeli | Büşra Yaprak Bayrak | Maksut Görkem Aksu

Yayıncı: Kocaeli University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 2, pp.53-61

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326661

pISSN: 2149-8571

ependymoma

adult

radiotherapy

histology

Sayı

Yazarlar:

Ayşegül Üçüncü Kefeli | Büşra Yaprak Bayrak | Maksut Görkem Aksu

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.10 Issue 2, pp.53-61

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326661

pISSN:

2149-8571