Exploring the anti-cancer potential of Ixora extracts: A multi-cell line approach

N.A.

Makale detayları

Exploring the anti-cancer potential of Ixora extracts: A multi-cell line approach

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 5, pp.1823-1834

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342407

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Bioactive anticancer compounds like alkaloid camptothecin and flavonoids rutin, quercetin and kaempferol have been isolated from Ixora coccinea. Being commercially important, research towards finding more plants with anticancer compounds belonging to genus Ixora is on the forefront. Anti cell proliferative potential of ethanolic plant part extracts of I. pavetta, I. barbata, I. javanica and I. undulata were studied against three cancer cell lines namely, Human leukemia cancer cell line K-562, Human breast cancer cell line MDA-MB-231 and Human lung cancer cell line A-549 using SRB assay. The result of anti-cell proliferative activity is further correlated with the total flavonoid content of aerial parts and total alkaloid content of underground parts of plants estimated by spectrophotometric assay. The root extract of I. javanica exhibited the best results with GI50 values of 10 µgml against all the three cancer cell lines studied. Interestingly, the total alkaloid content was also highest in roots of I. javanica possibly pointing some novel alkaloid to be responsible for its strong anti-cell proliferative activity. Bark extracts of I. javanica, I. pavetta and I. barbata also exhibited GI50 values of 10 µgml specifically against one of the cell lines studied namely - Human leukemia cancer cell line K-562. All three barks mentioned above also showed higher levels of total alkaloids. This is the first study reporting the anti-cell proliferative potential of root and bark extracts of I. javanica and I. barbata. These plants possess in their roots and bark some alkaloids with strong anti-cell proliferative activity which needs further investigation.

 Bioactive anticancer compounds like alkaloid camptothecin and flavonoids rutin, quercetin and kaempferol have been isolated from Ixora coccinea. Being commercially important, research towards finding more plants with anticancer compounds belonging to genus Ixora is on the forefront. Anti cell proliferative potential of ethanolic plant part extracts of I. pavetta, I. barbata, I. javanica and I. undulata were studied against three cancer cell lines namely, Human leukemia cancer cell line K-562, Human breast cancer cell line MDA-MB-231 and Human lung cancer cell line A-549 using SRB assay. The result of anti-cell proliferative activity is further correlated with the total flavonoid content of aerial parts and total alkaloid content of underground parts of plants estimated by spectrophotometric assay. The root extract of I. javanica exhibited the best results with GI50 values of 10 µgml against all the three cancer cell lines studied. Interestingly, the total alkaloid content was also highest in roots of I. javanica possibly pointing some novel alkaloid to be responsible for its strong anti-cell proliferative activity. Bark extracts of I. javanica, I. pavetta and I. barbata also exhibited GI50 values of 10 µgml specifically against one of the cell lines studied namely - Human leukemia cancer cell line K-562. All three barks mentioned above also showed higher levels of total alkaloids. This is the first study reporting the anti-cell proliferative potential of root and bark extracts of I. javanica and I. barbata. These plants possess in their roots and bark some alkaloids with strong anti-cell proliferative activity which needs further investigation.

 Bioactive anticancer compounds like alkaloid camptothecin and flavonoids rutin, quercetin and kaempferol have been isolated from Ixora coccinea. Being commercially important, research towards finding more plants with anticancer compounds belonging to genus Ixora is on the forefront. Anti cell proliferative potential of ethanolic plant part extracts of I. pavetta, I. barbata, I. javanica and I. undulata were studied against three cancer cell lines namely, Human leukemia cancer cell line K-562, Human breast cancer cell line MDA-MB-231 and Human lung cancer cell line A-549 using SRB assay. The result of anti-cell proliferative activity is further correlated with the total flavonoid content of aerial parts and total alkaloid content of underground parts of plants estimated by spectrophotometric assay. The root extract of I. javanica exhibited the best results with GI50 values of 10 µgml against all the three cancer cell lines studied. Interestingly, the total alkaloid content was also highest in roots of I. javanica possibly pointing some novel alkaloid to be responsible for its strong anti-cell proliferative activity. Bark extracts of I. javanica, I. pavetta and I. barbata also exhibited GI50 values of 10 µgml specifically against one of the cell lines studied namely - Human leukemia cancer cell line K-562. All three barks mentioned above also showed higher levels of total alkaloids. This is the first study reporting the anti-cell proliferative potential of root and bark extracts of I. javanica and I. barbata. These plants possess in their roots and bark some alkaloids with strong anti-cell proliferative activity which needs further investigation.

 Bioactive anticancer compounds like alkaloid camptothecin and flavonoids rutin, quercetin and kaempferol have been isolated from Ixora coccinea. Being commercially important, research towards finding more plants with anticancer compounds belonging to genus Ixora is on the forefront. Anti cell proliferative potential of ethanolic plant part extracts of I. pavetta, I. barbata, I. javanica and I. undulata were studied against three cancer cell lines namely, Human leukemia cancer cell line K-562, Human breast cancer cell line MDA-MB-231 and Human lung cancer cell line A-549 using SRB assay. The result of anti-cell proliferative activity is further correlated with the total flavonoid content of aerial parts and total alkaloid content of underground parts of plants estimated by spectrophotometric assay. The root extract of I. javanica exhibited the best results with GI50 values of 10 µgml against all the three cancer cell lines studied. Interestingly, the total alkaloid content was also highest in roots of I. javanica possibly pointing some novel alkaloid to be responsible for its strong anti-cell proliferative activity. Bark extracts of I. javanica, I. pavetta and I. barbata also exhibited GI50 values of 10 µgml specifically against one of the cell lines studied namely - Human leukemia cancer cell line K-562. All three barks mentioned above also showed higher levels of total alkaloids. This is the first study reporting the anti-cell proliferative potential of root and bark extracts of I. javanica and I. barbata. These plants possess in their roots and bark some alkaloids with strong anti-cell proliferative activity which needs further investigation.

Makale detayları

Exploring the anti-cancer potential of Ixora extracts: A multi-cell line approach

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 5, pp.1823-1834

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342407

pISSN:

2630-6344

Ixora species

flavonoid content

alkaloid content

K-562 cell line

MDA-MB-231 cell line

A-549 cell line

anti-cell proliferative

SRB assay

Sayı

Makale detayları

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Botany

Dergi: Journal of Research in Pharmacy Vol.29 Issue 5, pp.1823-1834

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001342407

pISSN: 2630-6344

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Botany

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 5, pp.1823-1834

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001342407

pISSN:

2630-6344