Determination of the Distribution of the rs2069514 and rs762551 Alleles of the Cyp1a2 Gene Related to Caffeine Metabolism in Professional Athletes

Begum YUCESOY; Sezgin KAPİCİ; Canan SERCAN; Turkan YİGİTBASİ; Nesrin EMEKLİ; Korkut ULUCAN

doi:https://doi.org/10.5152/EurJBiol.2017.1712

Makale detayları

Determination of the Distribution of the rs2069514 and rs762551 Alleles of the Cyp1a2 Gene Related to Caffeine Metabolism in Professional Athletes

Yazarlar:

Begum YUCESOY | Sezgin KAPİCİ | Canan SERCAN | Turkan YİGİTBASİ | Nesrin EMEKLİ | Korkut ULUCAN

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2017 Vol.76 Issue 2, pp.69-73

Belge Tipi:

Makale

Yayın Tarihi:

12/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000424492

eISSN:

2618-6144

pISSN:

2602-2575

DOI:

https://doi.org/10.5152/EurJBiol.2017.1712

Özet:

 


The
objective of this study is to investigate allele distributions of the rs2069514
and rs762551 polymorphisms of the CYP1A2 gene which affect caffeine metabolism
in long-distance and short-distance runners in the Turkish population. 20
professional athletes in total were included in the study within the age range
of 18-24, 10 of whom were long-distance (female, n=5; Male, n=5) and 10 of whom
were short-distance (Female, n=5; Male, n=5) runners. DNA isolation from the
athletes was performed from peripheral blood samples and genotyping was
determined using the technique of Real Time-PCR. According to the obtained
data, the ratio of individuals having AA (n=6), GG (n=9) and AG (n=5) genotype
for the region of rs2069514 was found as 30%, 45% and 25% respectively. On the
other hand, the ratio for AA (n=4), CC (n=9) and AC (n=7) genotypes in the
region of rs762551 allele was determined as 20%, 45% and 35%. According to the
results, no significant variance regarding gender was found for either of the
different polymorphisms under study in long-distance and short-distance runners
while the genotype distributions varied between short and long-distance runners
only in the rs2069514 polymorphism. The GG genotype was observed in 9
short-distance runners while it was observed in none of the long-distance
runners. As a result, the fact that the GG genotype in case of the Rs2069514
polymorphism was observed in nine of the ten short-distance runners suggests
that the athletes in this group metabolize caffeine slowly and this should be
considered in the caffeine intake. 

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Makale detayları

Determination of the Distribution of the rs2069514 and rs762551 Alleles of the Cyp1a2 Gene Related to Caffeine Metabolism in Professional Athletes

Yazarlar: Begum YUCESOY | Sezgin KAPİCİ | Canan SERCAN | Turkan YİGİTBASİ | Nesrin EMEKLİ | Korkut ULUCAN

Yayıncı: Istanbul University

Dergi: European Journal of Biology 2017 Vol.76 Issue 2, pp.69-73

Belge Tipi: Makale

Yayın Tarihi: 12/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000424492

eISSN: 2618-6144

pISSN: 2602-2575

DOI: https://doi.org/10.5152/EurJBiol.2017.1712

Sayı

Yazarlar:

Begum YUCESOY | Sezgin KAPİCİ | Canan SERCAN | Turkan YİGİTBASİ | Nesrin EMEKLİ | Korkut ULUCAN

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2017 Vol.76 Issue 2, pp.69-73

Belge Tipi:

Makale

Yayın Tarihi:

12/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000424492

eISSN:

2618-6144

pISSN:

2602-2575

DOI:

https://doi.org/10.5152/EurJBiol.2017.1712