Immunohistochemical Determination Of Vasoactive Intestinal Peptide(VIP) Levels In Smokers and Non-Smokers Chronic Periodontitis Patients And Periodontal Healthy Individuals

Mustafa Şimşekyılmaz; Taner Arabacı; Elif Bilici; Beyza Nur Şahin

Makale detayları

Immunohistochemical Determination Of Vasoactive Intestinal Peptide(VIP) Levels In Smokers and Non-Smokers Chronic Periodontitis Patients And Periodontal Healthy Individuals

Yazarlar:

Mustafa Şimşekyılmaz | Taner Arabacı | Elif Bilici | Beyza Nur Şahin

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Diş Hekimliği

Dergi:

Türk Diş Hekimliği Araştırma Dergisi Vol.2 Issue 1, pp.154-162

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290803

pISSN:

2822-4310

Anahtar kelimeler:

Özet:

 Background: The main aim of this study to investigate the effect of periodontal status and smoking on vasoactive intestinal peptideVIP levels on periodontal tissue. Material and Method: Patients were divided four groups. Groups were named non-smokers and periodontal healthy individualsH, smokers and periodontal healthy individualsHS, non-smokers and chronic periodontitis patientsCP, smokers and chronic periodontitis patientsCPS. Collected periodontal tissue were stained immunohistochemically and then the numerical densities of the VIP cells were determined by steorology method. Results: VIP receptor numerical density levels were statistically significant between all groups p 0.05. A significant difference was observed between H, HS and CP groups at the VIP level p 0.05. No significant difference was observed between CP and CPS groups p 0.05. Conclusion: The VIP acts as an anti-inflammatory neuropeptide that affects the cytokines in the pro-inflammatory pathway. There is an increase at the level of this protein and its receptor in periodontal tissue when patients has periodontal disease or they are smokers.

 Background: The main aim of this study to investigate the effect of periodontal status and smoking on vasoactive intestinal peptideVIP levels on periodontal tissue. Material and Method: Patients were divided four groups. Groups were named non-smokers and periodontal healthy individualsH, smokers and periodontal healthy individualsHS, non-smokers and chronic periodontitis patientsCP, smokers and chronic periodontitis patientsCPS. Collected periodontal tissue were stained immunohistochemically and then the numerical densities of the VIP cells were determined by steorology method. Results: VIP receptor numerical density levels were statistically significant between all groups p 0.05. A significant difference was observed between H, HS and CP groups at the VIP level p 0.05. No significant difference was observed between CP and CPS groups p 0.05. Conclusion: The VIP acts as an anti-inflammatory neuropeptide that affects the cytokines in the pro-inflammatory pathway. There is an increase at the level of this protein and its receptor in periodontal tissue when patients has periodontal disease or they are smokers.

 Background: The main aim of this study to investigate the effect of periodontal status and smoking on vasoactive intestinal peptideVIP levels on periodontal tissue. Material and Method: Patients were divided four groups. Groups were named non-smokers and periodontal healthy individualsH, smokers and periodontal healthy individualsHS, non-smokers and chronic periodontitis patientsCP, smokers and chronic periodontitis patientsCPS. Collected periodontal tissue were stained immunohistochemically and then the numerical densities of the VIP cells were determined by steorology method. Results: VIP receptor numerical density levels were statistically significant between all groups p 0.05. A significant difference was observed between H, HS and CP groups at the VIP level p 0.05. No significant difference was observed between CP and CPS groups p 0.05. Conclusion: The VIP acts as an anti-inflammatory neuropeptide that affects the cytokines in the pro-inflammatory pathway. There is an increase at the level of this protein and its receptor in periodontal tissue when patients has periodontal disease or they are smokers.

 Amaç: Periodontal durum ve sigara kullanımının vazoaktif intestinal peptitVIP seviyelerine etkisini incelemek. Gereç ve Yöntem: Kronik periodontitisli KP ve periodontal sağlıklı sigara içen ve içmeyen dört grup oluşturulmuştur. Sigara kullanımı yok ve periodontal açıdan sağlıklı bireyler:S, Sigara kullanımı var ve periodontal açıdan sağlıklı bireyler:SS, Sigara kullanımı yok ve kronik periodontitisli bireyler:KP, Sigara kullanımı var ve kronik periodontitisli bireyler:KPS. Alınan periodontal dokular immünohistokimyasal olarak boyanmış ve VIP hücrelerin steoroloji yöntemiyle ortalama sayısal yoğunlukları belirlenmiştir. Bulgular: Bütün gruplar arasında VIP reseptör ortalama sayısal yoğunluk seviyelerinde istatistiksel olarak anlamlı fark bulunmuştur p0.05. VIPte ise S, SS, KP grupları arasında anlamlı fark gözlenirken p0.05; KP ve KPS grupları arasında anlamlı fark gözlenmemiştir p0.05. Sonuç: Pro-inflamatuar yolaktaki sitokinleri etkileyen VIP anti-inflamatuar bir nöropeptit olarak çalışmaktadır. Bu proteinde ve reseptöründe, KP ve sigara kullanımı ile periodontal dokulardaki seviyelerinde artış görülmektedir.

Makale detayları

Immunohistochemical Determination Of Vasoactive Intestinal Peptide(VIP) Levels In Smokers and Non-Smokers Chronic Periodontitis Patients And Periodontal Healthy Individuals

Yazarlar:

Mustafa Şimşekyılmaz | Taner Arabacı | Elif Bilici | Beyza Nur Şahin

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Diş Hekimliği

Dergi:

Türk Diş Hekimliği Araştırma Dergisi Vol.2 Issue 1, pp.154-162

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290803

pISSN:

2822-4310

vasoactive intestinal peptite

chronic periodontitis

smokingvazoaktif intestinal peptit

kronik periodontitis

sigara kullanımı

Sayı

Makale detayları

Immunohistochemical Determination Of Vasoactive Intestinal Peptide(VIP) Levels In Smokers and Non-Smokers Chronic Periodontitis Patients And Periodontal Healthy Individuals

Yazarlar: Mustafa Şimşekyılmaz | Taner Arabacı | Elif Bilici | Beyza Nur Şahin

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Diş Hekimliği

Dergi: Türk Diş Hekimliği Araştırma Dergisi Vol.2 Issue 1, pp.154-162

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001290803

pISSN: 2822-4310

vasoactive intestinal peptite

chronic periodontitis

smokingvazoaktif intestinal peptit

kronik periodontitis

sigara kullanımı

Sayı

Yazarlar:

Mustafa Şimşekyılmaz | Taner Arabacı | Elif Bilici | Beyza Nur Şahin

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Diş Hekimliği

Dergi:

Türk Diş Hekimliği Araştırma Dergisi Vol.2 Issue 1, pp.154-162

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001290803

pISSN:

2822-4310