Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition

Gülsüm Yıldız; Betül Demirci; Halide Edip Temel; Neşe Kırımer

Makale detayları

Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition

Yazarlar:

Gülsüm Yıldız | Betül Demirci | Halide Edip Temel | Neşe Kırımer

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.2160-2169

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346804

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The essential oil EO of Origanum minutiflorum O. Schwarz et P. H. Davis was obtained by the hydrodistillation method. The analysis of the EO was conducted using Gas Chromatography GC and Gas ChromatographyMass Spectrometry GCMS. The yield of the EO was determined to be 3.9. Fifty-six compounds were identified, constituting 97.8 of the EO. The EO was rich in carvacrol at a rate of 83.3, and the other major compounds were p-cymene 3.0, β-caryophyllene 1.3, trans-sabinene hydrate 1.1, γ-terpinene 1.1, borneol 1.1, and terpinene-4-ol 1.0. While the EO 100 µgmL demonstrated the highest inhibition on cyclooxygenase-1 COX-1 with 55.26, the inhibitory activities on the other enzymes were as follows: cyclooxygenase-2 COX-2; 33.10, and matrix metalloproteinase-9 MMP-9; 12.87. The EO had no inhibition on lipoxygenase LOX. In this research, inhibitory activity of the EO of O. minutiflorum on COXs and MMP-9 enzymes was reported for the first time.

 The essential oil EO of Origanum minutiflorum O. Schwarz et P. H. Davis was obtained by the hydrodistillation method. The analysis of the EO was conducted using Gas Chromatography GC and Gas ChromatographyMass Spectrometry GCMS. The yield of the EO was determined to be 3.9. Fifty-six compounds were identified, constituting 97.8 of the EO. The EO was rich in carvacrol at a rate of 83.3, and the other major compounds were p-cymene 3.0, β-caryophyllene 1.3, trans-sabinene hydrate 1.1, γ-terpinene 1.1, borneol 1.1, and terpinene-4-ol 1.0. While the EO 100 µgmL demonstrated the highest inhibition on cyclooxygenase-1 COX-1 with 55.26, the inhibitory activities on the other enzymes were as follows: cyclooxygenase-2 COX-2; 33.10, and matrix metalloproteinase-9 MMP-9; 12.87. The EO had no inhibition on lipoxygenase LOX. In this research, inhibitory activity of the EO of O. minutiflorum on COXs and MMP-9 enzymes was reported for the first time.

 The essential oil EO of Origanum minutiflorum O. Schwarz et P. H. Davis was obtained by the hydrodistillation method. The analysis of the EO was conducted using Gas Chromatography GC and Gas ChromatographyMass Spectrometry GCMS. The yield of the EO was determined to be 3.9. Fifty-six compounds were identified, constituting 97.8 of the EO. The EO was rich in carvacrol at a rate of 83.3, and the other major compounds were p-cymene 3.0, β-caryophyllene 1.3, trans-sabinene hydrate 1.1, γ-terpinene 1.1, borneol 1.1, and terpinene-4-ol 1.0. While the EO 100 µgmL demonstrated the highest inhibition on cyclooxygenase-1 COX-1 with 55.26, the inhibitory activities on the other enzymes were as follows: cyclooxygenase-2 COX-2; 33.10, and matrix metalloproteinase-9 MMP-9; 12.87. The EO had no inhibition on lipoxygenase LOX. In this research, inhibitory activity of the EO of O. minutiflorum on COXs and MMP-9 enzymes was reported for the first time.

 The essential oil EO of Origanum minutiflorum O. Schwarz et P. H. Davis was obtained by the hydrodistillation method. The analysis of the EO was conducted using Gas Chromatography GC and Gas ChromatographyMass Spectrometry GCMS. The yield of the EO was determined to be 3.9. Fifty-six compounds were identified, constituting 97.8 of the EO. The EO was rich in carvacrol at a rate of 83.3, and the other major compounds were p-cymene 3.0, β-caryophyllene 1.3, trans-sabinene hydrate 1.1, γ-terpinene 1.1, borneol 1.1, and terpinene-4-ol 1.0. While the EO 100 µgmL demonstrated the highest inhibition on cyclooxygenase-1 COX-1 with 55.26, the inhibitory activities on the other enzymes were as follows: cyclooxygenase-2 COX-2; 33.10, and matrix metalloproteinase-9 MMP-9; 12.87. The EO had no inhibition on lipoxygenase LOX. In this research, inhibitory activity of the EO of O. minutiflorum on COXs and MMP-9 enzymes was reported for the first time.

Makale detayları

Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition

Yazarlar:

Gülsüm Yıldız | Betül Demirci | Halide Edip Temel | Neşe Kırımer

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.2160-2169

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346804

pISSN:

2630-6344

Origanum minutiflorum

Lamiaceae

essential oil

enzyme inhibitory activity

Sayı

Makale detayları

Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition

Yazarlar: Gülsüm Yıldız | Betül Demirci | Halide Edip Temel | Neşe Kırımer

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.27 Issue 5, pp.2160-2169

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346804

pISSN: 2630-6344

Origanum minutiflorum

Lamiaceae

essential oil

enzyme inhibitory activity

Sayı

Yazarlar:

Gülsüm Yıldız | Betül Demirci | Halide Edip Temel | Neşe Kırımer

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.2160-2169

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346804

pISSN:

2630-6344