Avascular necrosis less frequently found in systemic lupus erythematosus patients with the use of alternate day corticosteroid

İsmail DOĞAN; Umut KALYONCU; Levent KILIÇ; Ali AKDOĞAN; Ömer KARADAĞ; Sedat KİRAZ; Şaziye Şule Apraş BİLGEN; Ali İhsan ERTENLİ

doi:https://doi.org/10.3906/sag-1908-182

Makale detayları

Avascular necrosis less frequently found in systemic lupus erythematosus patients with the use of alternate day corticosteroid

Yazarlar:

İsmail DOĞAN | Umut KALYONCU | Levent KILIÇ | Ali AKDOĞAN | Ömer KARADAĞ | Sedat KİRAZ | Şaziye Şule Apraş BİLGEN | Ali İhsan ERTENLİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.219-224

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1908-182

Özet:

 

Background/aim: Avascular necrosis  AVN  is the death of bone due to compromise of blood flow. The etiology of AVN is multifactorial; corticosteroid usage is the second most significant factor after trauma, and systemic lupus erythematosus  SLE  is the most common underlying disease. The objective of this study was to assess the factors of AVN in SLE patients. Materials and methods: The study included 127 patients with SLE who fulfilled 1997 American College of Rheumatology  ACR  revised criteria. Demographic data, age at SLE diagnosis, disease duration, disease activity, body mass index, clinical findings, antiphospholipid syndrome, steroid usage, dose and duration, comorbid diseases, and smoking history were recorded. Results:  AVN  was  found  in  11  of  127   8.7%   SLE  patients.  Hyperlipidemia   P  <  0.001 ,  cushingoid  body  habitus   P  <  0.001 ,  and  proteinuria  P = 0.013  were found at higher rates in the AVN group. All of the 11 AVN cases had osteoporosis  P < 0.02 . In multivariate regression analysis, daily steroid usage was the only factor for development of AVN in SLE. Conclusion: The hypothesis of our study was that an alternate day steroid regimen may decrease AVN frequency in SLE patients.

Makale detayları

Avascular necrosis less frequently found in systemic lupus erythematosus patients with the use of alternate day corticosteroid

Yazarlar: İsmail DOĞAN | Umut KALYONCU | Levent KILIÇ | Ali AKDOĞAN | Ömer KARADAĞ | Sedat KİRAZ | Şaziye Şule Apraş BİLGEN | Ali İhsan ERTENLİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.219-224

Belge Tipi: Makale

Yayın Tarihi: 12/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749713

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1908-182

Sayı

Yazarlar:

İsmail DOĞAN | Umut KALYONCU | Levent KILIÇ | Ali AKDOĞAN | Ömer KARADAĞ | Sedat KİRAZ | Şaziye Şule Apraş BİLGEN | Ali İhsan ERTENLİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.219-224

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1908-182