The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts

Dewi Setyaningsih

Makale detayları

The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts

Yazarlar:

Dewi Setyaningsih

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1329-1337

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347875

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumins poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation SD. This studys objective was to understand drying temperatures effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105C, 115C, and 125C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency DE was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SDs yield increases as inlet temperature increases, from 33.60 at 105C to 35.75 at 115C to 39.30 at 125C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125C fits the zero-order model.

 After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumins poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation SD. This studys objective was to understand drying temperatures effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105C, 115C, and 125C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency DE was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SDs yield increases as inlet temperature increases, from 33.60 at 105C to 35.75 at 115C to 39.30 at 125C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125C fits the zero-order model.

 After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumins poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation SD. This studys objective was to understand drying temperatures effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105C, 115C, and 125C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency DE was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SDs yield increases as inlet temperature increases, from 33.60 at 105C to 35.75 at 115C to 39.30 at 125C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125C fits the zero-order model.

 After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumins poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation SD. This studys objective was to understand drying temperatures effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105C, 115C, and 125C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency DE was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SDs yield increases as inlet temperature increases, from 33.60 at 105C to 35.75 at 115C to 39.30 at 125C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125C fits the zero-order model.

Makale detayları

The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts

Yazarlar:

Dewi Setyaningsih

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1329-1337

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347875

pISSN:

2630-6344

Curcumin

ddsolver; dissolution

kinetic release; piperine

solid dispersion

spray drying

Sayı

Makale detayları

The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts

Yazarlar: Dewi Setyaningsih

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 4, pp.1329-1337

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347875

pISSN: 2630-6344

Curcumin

ddsolver; dissolution

kinetic release; piperine

solid dispersion

spray drying

Sayı

Yazarlar:

Dewi Setyaningsih

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1329-1337

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347875

pISSN:

2630-6344