Fourier Dönüşümlü Kızılötesi Spektroskopisinin Prostat Kanseri Teşhisinde Kullanılabilirliğinin Araştırılması

Mevlut ALBAYRAK

Makale detayları

Fourier Dönüşümlü Kızılötesi Spektroskopisinin Prostat Kanseri Teşhisinde Kullanılabilirliğinin Araştırılması

Yazarlar:

Mevlut ALBAYRAK

Yayıncı:

Igdir University

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Institute of Science and Technology 2018 Vol.8 Issue 4, pp.223-227

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000465635

Sıklık:

Üç Aylık

eISSN:

2536-4618

Özet:

 


Fourier Transform-Infrared Spectroscopy (FT-IR) is an analytical technique used to identify in

organic and some cases inorganic materials. This technique measures the absorption of infrared radiation by the

sample material versus wavelength. The infrared absorption bands identify molecular components and structures.

Prostate cancer is cancer that occurs in the prostate a small walnut shaped gland in men that produces the seminal

fluid that nourishes and transports sperm. Prostate cancer is one of the most common types of cancer in men.

Prostate cancer that is detected early when it’s still confined to the prostate gland has a better chance of successful

treatment. It is aimed to develop a new alternative chemometrics assisted method to separate and characterize

prostat cancer tumors from healthy cells by simple, cheap and rapid FT-IR method with good accuracy and

sensitivity. In order to perform such a study paraffin embedded blocks including both cancer and healthy cells

which are labelled by the histopathologic measurements were cut to 20 microns thick were located on a microscope

slide and deparafinized. Both healthy (n=10) and cancerous tissues (n=10) were exposured to infrared light between

wavenumber of 50-4000 cm-1. Orthogonal partial least square analysis (O-PLS) algorithm which is an advanced

form of Principle Component Analysis (PCA) was applied to 20 samples to detect their behaviour against infrared

light in between 50-4000 cm-1. Obtained spectrums were evaluated on MATLAB software PLS Toolbox package

program. O-PLS analysis were carried out in order to separate cancer and healthy tissues. Sensitivity and specificity

of the proposed method is so high with the aid of Orthogonal Signal Correction (OSC) preprocessing method. As

a result, an alternative FT-IR method for the diagnosis of prostate cancer from paraffin blocks has been developed

and successfully applied.

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Makale detayları

Fourier Dönüşümlü Kızılötesi Spektroskopisinin Prostat Kanseri Teşhisinde Kullanılabilirliğinin Araştırılması

Yazarlar: Mevlut ALBAYRAK

Yayıncı: Igdir University

Ana Başlıklar: Kimya mühendisliği

Dergi: Journal of the Institute of Science and Technology 2018 Vol.8 Issue 4, pp.223-227

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000465635

Sıklık: Üç Aylık

eISSN: 2536-4618

Sayı

Yazarlar:

Mevlut ALBAYRAK

Yayıncı:

Igdir University

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Institute of Science and Technology 2018 Vol.8 Issue 4, pp.223-227

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000465635

Sıklık:

Üç Aylık

eISSN:

2536-4618