Long-term follow-up of infective endocarditis: Rates of reinfection, mortality, and predictors of outcome

Mehmet Altunova; Tugba Aktemur; Serpil Öztürk; Ali Evsen; Uğur Köktürk; Mehmet Köseoğlu; Gamze Babur Güler

Makale detayları

Long-term follow-up of infective endocarditis: Rates of reinfection, mortality, and predictors of outcome

Yazarlar:

Mehmet Altunova | Tugba Aktemur | Serpil Öztürk | Ali Evsen | Uğur Köktürk | Mehmet Köseoğlu | Gamze Babur Güler

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.366-372

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330829

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: Infective endocarditis IE is a severe condition characterized by high mortality rates. We aimed to assess reinfection and mortality rates in IE patients at a tertiary referral center during long-term follow-up. Patients and Methods: We retrospectively analyzed 204 patients meeting modified Duke criteria for definite IE between 2009 and 2019. Early reinfection was defined as occurrence within 6 months, and late reinfection was defined as occurrence 6 months after the initial diagnosis. Results: Mean follow-up duration was 40.3  26.4 months. Valve surgery was performed in 125 patients 69.8, while 54 30.2 received medical therapy alone. Early reinfection was seen in 9 patients 5.1, and late reinfection in 12 patients 6.7. Staphylococci 41.9, Streptococci 26.3, and Enterococci 15.6 were common pathogens. Peripheral limb emboli predicted reinfection HR 4.118, 95 CI 1.471-11.528, p0.007. Survival rates at 1, 2, and 5 years were 70.2, 65.7, and 57.3, respectively. Age HR 1.030, 95 CI 1.011  1.049, p0.002, peripheral limb emboli HR 2.994, 95 CI 1.509-5.940, p0.002, and septic shock HR 2.357, 95 CI 1.097-5.065, p0.028 predicted mortality. Conclusion: Infective endocarditis mortality rates remain high regardless of reinfection. Peripheral limb emboli independently determine reinfection and mortality. Careful management of this group may reduce morbidity and mortality.

 Objective: Infective endocarditis IE is a severe condition characterized by high mortality rates. We aimed to assess reinfection and mortality rates in IE patients at a tertiary referral center during long-term follow-up. Patients and Methods: We retrospectively analyzed 204 patients meeting modified Duke criteria for definite IE between 2009 and 2019. Early reinfection was defined as occurrence within 6 months, and late reinfection was defined as occurrence 6 months after the initial diagnosis. Results: Mean follow-up duration was 40.3  26.4 months. Valve surgery was performed in 125 patients 69.8, while 54 30.2 received medical therapy alone. Early reinfection was seen in 9 patients 5.1, and late reinfection in 12 patients 6.7. Staphylococci 41.9, Streptococci 26.3, and Enterococci 15.6 were common pathogens. Peripheral limb emboli predicted reinfection HR 4.118, 95 CI 1.471-11.528, p0.007. Survival rates at 1, 2, and 5 years were 70.2, 65.7, and 57.3, respectively. Age HR 1.030, 95 CI 1.011  1.049, p0.002, peripheral limb emboli HR 2.994, 95 CI 1.509-5.940, p0.002, and septic shock HR 2.357, 95 CI 1.097-5.065, p0.028 predicted mortality. Conclusion: Infective endocarditis mortality rates remain high regardless of reinfection. Peripheral limb emboli independently determine reinfection and mortality. Careful management of this group may reduce morbidity and mortality.

 Objective: Infective endocarditis IE is a severe condition characterized by high mortality rates. We aimed to assess reinfection and mortality rates in IE patients at a tertiary referral center during long-term follow-up. Patients and Methods: We retrospectively analyzed 204 patients meeting modified Duke criteria for definite IE between 2009 and 2019. Early reinfection was defined as occurrence within 6 months, and late reinfection was defined as occurrence 6 months after the initial diagnosis. Results: Mean follow-up duration was 40.3  26.4 months. Valve surgery was performed in 125 patients 69.8, while 54 30.2 received medical therapy alone. Early reinfection was seen in 9 patients 5.1, and late reinfection in 12 patients 6.7. Staphylococci 41.9, Streptococci 26.3, and Enterococci 15.6 were common pathogens. Peripheral limb emboli predicted reinfection HR 4.118, 95 CI 1.471-11.528, p0.007. Survival rates at 1, 2, and 5 years were 70.2, 65.7, and 57.3, respectively. Age HR 1.030, 95 CI 1.011  1.049, p0.002, peripheral limb emboli HR 2.994, 95 CI 1.509-5.940, p0.002, and septic shock HR 2.357, 95 CI 1.097-5.065, p0.028 predicted mortality. Conclusion: Infective endocarditis mortality rates remain high regardless of reinfection. Peripheral limb emboli independently determine reinfection and mortality. Careful management of this group may reduce morbidity and mortality.

 Objective: Infective endocarditis IE is a severe condition characterized by high mortality rates. We aimed to assess reinfection and mortality rates in IE patients at a tertiary referral center during long-term follow-up. Patients and Methods: We retrospectively analyzed 204 patients meeting modified Duke criteria for definite IE between 2009 and 2019. Early reinfection was defined as occurrence within 6 months, and late reinfection was defined as occurrence 6 months after the initial diagnosis. Results: Mean follow-up duration was 40.3  26.4 months. Valve surgery was performed in 125 patients 69.8, while 54 30.2 received medical therapy alone. Early reinfection was seen in 9 patients 5.1, and late reinfection in 12 patients 6.7. Staphylococci 41.9, Streptococci 26.3, and Enterococci 15.6 were common pathogens. Peripheral limb emboli predicted reinfection HR 4.118, 95 CI 1.471-11.528, p0.007. Survival rates at 1, 2, and 5 years were 70.2, 65.7, and 57.3, respectively. Age HR 1.030, 95 CI 1.011  1.049, p0.002, peripheral limb emboli HR 2.994, 95 CI 1.509-5.940, p0.002, and septic shock HR 2.357, 95 CI 1.097-5.065, p0.028 predicted mortality. Conclusion: Infective endocarditis mortality rates remain high regardless of reinfection. Peripheral limb emboli independently determine reinfection and mortality. Careful management of this group may reduce morbidity and mortality.

Makale detayları

Long-term follow-up of infective endocarditis: Rates of reinfection, mortality, and predictors of outcome

Yazarlar:

Mehmet Altunova | Tugba Aktemur | Serpil Öztürk | Ali Evsen | Uğur Köktürk | Mehmet Köseoğlu | Gamze Babur Güler

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.366-372

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330829

pISSN:

1019-1941

Infective endocarditis

Reinfection

Long-term mortality

Sayı

Makale detayları

Long-term follow-up of infective endocarditis: Rates of reinfection, mortality, and predictors of outcome

Yazarlar: Mehmet Altunova | Tugba Aktemur | Serpil Öztürk | Ali Evsen | Uğur Köktürk | Mehmet Köseoğlu | Gamze Babur Güler

Yayıncı: Marmara University

Ana Başlıklar: Surgery (Other)

Dergi: Marmara Medical Journal Vol.37 Issue 3, pp.366-372

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330829

pISSN: 1019-1941

Infective endocarditis

Reinfection

Long-term mortality

Sayı

Yazarlar:

Mehmet Altunova | Tugba Aktemur | Serpil Öztürk | Ali Evsen | Uğur Köktürk | Mehmet Köseoğlu | Gamze Babur Güler

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.366-372

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330829

pISSN:

1019-1941