The results of nasopharyngeal cancer patients treated by simultaneous integrated boost technique and concomitant chemotherapy

Mehmet Faik ÇETİNDAĞ; Atiye Yilmaz ÖZSAVRAN; Bülent YALÇIN; İclal ÇETİNDAĞ; Şeyda TÜRKÖLMEZ; Karabekir ERCAN; Dinçer YEĞEN

Makale detayları

The results of nasopharyngeal cancer patients treated by simultaneous integrated boost technique and concomitant chemotherapy

Yazarlar:

Mehmet Faik ÇETİNDAĞ | Atiye Yilmaz ÖZSAVRAN | Bülent YALÇIN | İclal ÇETİNDAĞ | Şeyda TÜRKÖLMEZ | Karabekir ERCAN | Dinçer YEĞEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.558-565

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750194

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:  To  assess  the  efficacy  and  side  effects  of  concurrent  weekly  chemotherapy  and  radiotherapy  with  simultaneous  integrated boost (SIB) technique for nasopharyngeal cancer (NPC). Materials and methods: A total of 51 consecutive patients with diagnosis of NPC were treated between February 2010 and December 2015. The median dose for PTV70 (range: 60-82) was given in 33 fractions (range: 31-35). Forty-five of the patients received concomitant weekly chemotherapy between 3-7 cycles (median 6). Eleven patients received neoadjuvant and thirty-nine patients received adjuvant chemotherapy. Results: At a median follow-up 43 months (range: 2-76) the estimated 5-year overall survival and disease-free survival were 74.6% and 62.6%, respectively. Conclusion: In  radiotherapy  of  advanced  NPC,  generally  a  considerable  amount  of  normal  head  and  neck  tissues  might  have  to  be  irradiated in addition to gross tumor volume, involved node, and elective neck irradiation. Together with chemoradiotherapy, poor oral hygiene and inadequate nutritional support result in excessive morbidity. Despite loco-regional success of concurrent chemoradiotherapy, distant metastasis is still the major pattern of treatment failure in the intensity modulated radiotherapy era. We need to improve our adjuvant chemotherapy regimens or develop new drugs.

Makale detayları

The results of nasopharyngeal cancer patients treated by simultaneous integrated boost technique and concomitant chemotherapy

Yazarlar: Mehmet Faik ÇETİNDAĞ | Atiye Yilmaz ÖZSAVRAN | Bülent YALÇIN | İclal ÇETİNDAĞ | Şeyda TÜRKÖLMEZ | Karabekir ERCAN | Dinçer YEĞEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.558-565

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750194

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Mehmet Faik ÇETİNDAĞ | Atiye Yilmaz ÖZSAVRAN | Bülent YALÇIN | İclal ÇETİNDAĞ | Şeyda TÜRKÖLMEZ | Karabekir ERCAN | Dinçer YEĞEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.558-565

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750194

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144