Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Oğuz EROĞLU; Nermin DİNDAR BADEM; Ayşe BACCIOĞLU; Ertan CÖMERTPAY; Salim NEŞELİOĞLU; Özcan EREL

doi:https://doi.org/10.18621/eurj.425178

Makale detayları

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Yazarlar:

Oğuz EROĞLU | Nermin DİNDAR BADEM | Ayşe BACCIOĞLU | Ertan CÖMERTPAY | Salim NEŞELİOĞLU | Özcan EREL

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2019 Vol.5 Issue 2, pp.250-257

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000662808

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.425178

Özet:

 


Objectives: The
severity of inflammation occurring during chronic obstructive pulmonary disease
(COPD) is closely associated with oxidative stress. The aim of this study was
to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and
ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD
patients. 

Methods: This
prospective study was performed with COPD patients presenting to the Kırıkkale
University Hospital and with healthy volunteers. Subjects’ demographic data
(age, sex, body mass index, and smoking status), native thiol (NT), total thiol
(TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were
recorded. Statistical analysis was performed with SPSS 21.0 software. 

Results: One hundred ninety
subjects were enrolled in the study, 141 COPD patients and 49 healthy
volunteers. No difference was determined between the patient and control groups
in terms of age, sex or body mass index. The antioxidant markers; NT and TT
levels and NT/TT ratio were significantly lower in the patient group compared
to the control group (p < 0.001, p < 0.001, and p
< 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT
ratios were significantly higher in the patient group (p = 0.006, p
= 0.003, and p = 0.003, respectively). Significant negative correlation
was determined between antioxidant and oxidant parameters. Sensitivity values
were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA:
77.8%. Conclusions: TDH was
impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used
to monitor oxidative stress emerging in COPD. 


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Makale detayları

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Yazarlar: Oğuz EROĞLU | Nermin DİNDAR BADEM | Ayşe BACCIOĞLU | Ertan CÖMERTPAY | Salim NEŞELİOĞLU | Özcan EREL

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2019 Vol.5 Issue 2, pp.250-257

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000662808

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.425178

Sayı

Yazarlar:

Oğuz EROĞLU | Nermin DİNDAR BADEM | Ayşe BACCIOĞLU | Ertan CÖMERTPAY | Salim NEŞELİOĞLU | Özcan EREL

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2019 Vol.5 Issue 2, pp.250-257

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000662808

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.425178