Osteoprotegerin as a marker of atherosclerosis in type 1 and type 2 diabetic patients

Çiğdem ALKAÇ; Burak ALKAÇ; Feray AKBAŞ; Hale ARAL; Yeşim KARAGÖZ; Esma Güldal ALTUNOĞLU

Makale detayları

Osteoprotegerin as a marker of atherosclerosis in type 1 and type 2 diabetic patients

Yazarlar:

Çiğdem ALKAÇ | Burak ALKAÇ | Feray AKBAŞ | Hale ARAL | Yeşim KARAGÖZ | Esma Güldal ALTUNOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1306-1311

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752419

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background/aim: The aim of this study was to investigate the availability of osteoprotegerin (OPG) as a marker of atherosclerosis and compare serum OPG levels with ankle-brachial index (ABI) in diabetic patients.  Materials and methods: A total of 31 type 1 and 31 type 2 diabetic patients without macrovascular complications and 20 healthy volunteers were included. Serum OPG levels and ABI were measured.  Results: The duration of diabetes was significantly higher in type 1 diabetics than in type 2, although there was no significant difference between mean HbA1c levels. There was a weak and inverse correlation between OPG and atherosclerosis in type 1 diabetics only (P = 0.046, r = -0.360). There was a weak, positive correlation between ABI and HbA1c in all participant groups (P = 0.047, r = 0.220), and a weak-medium correlation in type 2 diabetics (P = 0.021, r = 0.414). After the adjustment of OPG levels to atherosclerosis risk factors, only the age factor was found to be effective on OPG.  Conclusion: The inverse correlation of serum OPG with atherosclerosis in type 1 diabetics suggests that atherosclerosis may be related to increased duration of diabetes. Since the study participants did not show macrovascular complications, future prospective studies on the development of diabetic complications and correlation with OPG might give further information about the availability of OPG as a marker of atherosclerosis.

 

Background/aim: The aim of this study was to investigate the availability of osteoprotegerin (OPG) as a marker of atherosclerosis and compare serum OPG levels with ankle-brachial index (ABI) in diabetic patients.  Materials and methods: A total of 31 type 1 and 31 type 2 diabetic patients without macrovascular complications and 20 healthy volunteers were included. Serum OPG levels and ABI were measured.  Results: The duration of diabetes was significantly higher in type 1 diabetics than in type 2, although there was no significant difference between mean HbA1c levels. There was a weak and inverse correlation between OPG and atherosclerosis in type 1 diabetics only (P = 0.046, r = -0.360). There was a weak, positive correlation between ABI and HbA1c in all participant groups (P = 0.047, r = 0.220), and a weak-medium correlation in type 2 diabetics (P = 0.021, r = 0.414). After the adjustment of OPG levels to atherosclerosis risk factors, only the age factor was found to be effective on OPG.  Conclusion: The inverse correlation of serum OPG with atherosclerosis in type 1 diabetics suggests that atherosclerosis may be related to increased duration of diabetes. Since the study participants did not show macrovascular complications, future prospective studies on the development of diabetic complications and correlation with OPG might give further information about the availability of OPG as a marker of atherosclerosis.

Makale detayları

Osteoprotegerin as a marker of atherosclerosis in type 1 and type 2 diabetic patients

Yazarlar:

Çiğdem ALKAÇ | Burak ALKAÇ | Feray AKBAŞ | Hale ARAL | Yeşim KARAGÖZ | Esma Güldal ALTUNOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1306-1311

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752419

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Diabetes mellitus

atherosclerosis

osteoprotegerin

ankle-brachial index

Sayı

Makale detayları

Osteoprotegerin as a marker of atherosclerosis in type 1 and type 2 diabetic patients

Yazarlar: Çiğdem ALKAÇ | Burak ALKAÇ | Feray AKBAŞ | Hale ARAL | Yeşim KARAGÖZ | Esma Güldal ALTUNOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1306-1311

Belge Tipi: Makale

Yayın Tarihi: 12/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752419

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Diabetes mellitus

atherosclerosis

osteoprotegerin

ankle-brachial index

Sayı

Yazarlar:

Çiğdem ALKAÇ | Burak ALKAÇ | Feray AKBAŞ | Hale ARAL | Yeşim KARAGÖZ | Esma Güldal ALTUNOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 6, pp.1306-1311

Belge Tipi:

Makale

Yayın Tarihi:

12/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752419

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144