Prognostic value of systemic immune-inflammatory index in hospitalized adolescent COVID-19 patients

Hanife Tuğçe Çağlar; Sevgi Pekcan; Gökçen Ünal; Fatih Ercan; Aslı İmran Yılmaz; Ozge Metin; Mustafa Gençeli; Mehmet Özdemir; Fatma Nur Ayman; Suat Savaş; Bahar Ece Tokdemir

Makale detayları

Prognostic value of systemic immune-inflammatory index in hospitalized adolescent COVID-19 patients

Yazarlar:

Hanife Tuğçe Çağlar | Sevgi Pekcan | Gökçen Ünal | Fatih Ercan | Aslı İmran Yılmaz | Ozge Metin | Mustafa Gençeli | Mehmet Özdemir | Fatma Nur Ayman | Suat Savaş | Bahar Ece Tokdemir

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.35 Issue 1, pp.123-128

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339640

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Background: A new parameter called systemic immune-inflammatory index SII, which is based on neutrophil-lymphocyte ratio NLR and platelet count, is used to examine the inflammatory and immune status of patients. The aim of this study was to evaluate the prognostic value of SII in adolescents diagnosed with COVID-19 and to compare SII with other biomarkers such as C-reactive protein CRPalbumin Alb ratio, D-dimer, lactate and NLR. Methods: The medical records of hospitalized adolescent COVID-19 patients between April 1, 2020, and March 31, 2022, were retrospectively reviewed. A cut-off value for SII was obtained to examine the predictive value of SII for intensive care unit ICU admission as the primary outcome. Results: A total of 177 patients with a mean age of 165.89  26.60 months were included in the study. 97 54.8 of the patients were male. The most common presenting symptom was fever n:102, 57.6. Median IQR SII was 799 951, lactate 1.9 1.53, NLR 10.19  6.77 and CRPAlb ratio 1.55 2.61. The cut-off value for SII in predicting ICU admission was 1111 sensitivity, 78.6; specificity, 75.2; likelihood ratio, 3.32; -likelihood ratio, 0.30; AUC:0.768 p0.001. While SII and CRPAlb ratio were better than lactate in predicting ICU admission p  0.03 and p  0.04, respectively, there was no statistical difference between SII and CRPAlb ratio p  0.05. Conclusion: The results of this study suggest that a high SII during hospitalization is associated with an increased likelihood of ICU admission in patients hospitalized with COVID-19. Although additional studies are needed to confirm and validate these findings, the evidence of this study supports SII is a valuable prognostic predictor of hospitilized patients with COVID-19.

 Background: A new parameter called systemic immune-inflammatory index SII, which is based on neutrophil-lymphocyte ratio NLR and platelet count, is used to examine the inflammatory and immune status of patients. The aim of this study was to evaluate the prognostic value of SII in adolescents diagnosed with COVID-19 and to compare SII with other biomarkers such as C-reactive protein CRPalbumin Alb ratio, D-dimer, lactate and NLR. Methods: The medical records of hospitalized adolescent COVID-19 patients between April 1, 2020, and March 31, 2022, were retrospectively reviewed. A cut-off value for SII was obtained to examine the predictive value of SII for intensive care unit ICU admission as the primary outcome. Results: A total of 177 patients with a mean age of 165.89  26.60 months were included in the study. 97 54.8 of the patients were male. The most common presenting symptom was fever n:102, 57.6. Median IQR SII was 799 951, lactate 1.9 1.53, NLR 10.19  6.77 and CRPAlb ratio 1.55 2.61. The cut-off value for SII in predicting ICU admission was 1111 sensitivity, 78.6; specificity, 75.2; likelihood ratio, 3.32; -likelihood ratio, 0.30; AUC:0.768 p0.001. While SII and CRPAlb ratio were better than lactate in predicting ICU admission p  0.03 and p  0.04, respectively, there was no statistical difference between SII and CRPAlb ratio p  0.05. Conclusion: The results of this study suggest that a high SII during hospitalization is associated with an increased likelihood of ICU admission in patients hospitalized with COVID-19. Although additional studies are needed to confirm and validate these findings, the evidence of this study supports SII is a valuable prognostic predictor of hospitilized patients with COVID-19.

 Background: A new parameter called systemic immune-inflammatory index SII, which is based on neutrophil-lymphocyte ratio NLR and platelet count, is used to examine the inflammatory and immune status of patients. The aim of this study was to evaluate the prognostic value of SII in adolescents diagnosed with COVID-19 and to compare SII with other biomarkers such as C-reactive protein CRPalbumin Alb ratio, D-dimer, lactate and NLR. Methods: The medical records of hospitalized adolescent COVID-19 patients between April 1, 2020, and March 31, 2022, were retrospectively reviewed. A cut-off value for SII was obtained to examine the predictive value of SII for intensive care unit ICU admission as the primary outcome. Results: A total of 177 patients with a mean age of 165.89  26.60 months were included in the study. 97 54.8 of the patients were male. The most common presenting symptom was fever n:102, 57.6. Median IQR SII was 799 951, lactate 1.9 1.53, NLR 10.19  6.77 and CRPAlb ratio 1.55 2.61. The cut-off value for SII in predicting ICU admission was 1111 sensitivity, 78.6; specificity, 75.2; likelihood ratio, 3.32; -likelihood ratio, 0.30; AUC:0.768 p0.001. While SII and CRPAlb ratio were better than lactate in predicting ICU admission p  0.03 and p  0.04, respectively, there was no statistical difference between SII and CRPAlb ratio p  0.05. Conclusion: The results of this study suggest that a high SII during hospitalization is associated with an increased likelihood of ICU admission in patients hospitalized with COVID-19. Although additional studies are needed to confirm and validate these findings, the evidence of this study supports SII is a valuable prognostic predictor of hospitilized patients with COVID-19.

 Giriş: Nötrofil-lenfosit oranı NLR ve trombosit sayısına dayanan sistemik immün-inflamatuar indeks SII adı verilen yeni bir parametre, hastaların inflamatuar ve immün durumunu aynı anda değerlendirmek için kullanılmaktadır. Bu çalışmanın amacı COVID-19 tanısı alan adölesanlarda SIInin prognostik değerini değerlendirmek ve SIIyi C-reaktif protein CRP  albümin Alb oranı, D-dimer, laktat ve NLR gibi diğer prognostik belirteçlerle karşılaştırmaktır. Gereçler ve Yöntem: Hastanede yatan adölesan COVID-19 hastalarının 1 Nisan 2020 ve 31 Mart 2022 tarihleri arasındaki tıbbi kayıtları retrospektif olarak incelendi. Birincil sonlanım noktası olarak yoğun bakım ünitesine kabul kullanıldı. SIInin yoğun bakım ünitesine kabul için öngörücü değeri hesaplandı ve diğer biobelirteçler ile karşılaştırıldı. Bulgular: Yaş ortalaması 165,89  26,60 ay olan 177 hasta çalışmaya dahil edilmiştir. Hastaların 97 54,8 tanesi erkekti. En sık görülen başvuru semptomu ateşti n:102, 57,6. SII 799 951, laktat 1.9 1.53, NLR 10.19  6.77 ve CRPAlb oranı 1.55 2.61 idi. Yoğun bakım kabulü öngörmede SII için cut-off değeri 1111 idi sensitivite, 78,6; spesivite, 75,2; Likelihood ratio, 3,32; -likelihood ratio, 0,30; AUC:0,768 p0,001. SII ve CRPAlb oranı yoğun bakıma kabulü öngörmede laktattan daha iyi iken sırasıyla p  0,03 ve p  0,04, SII ve CRPAlb oranı arasında istatistiksel fark yoktu p  0,05. Sonuç: Bu çalışmanın sonuçları, COVID-19 ile hastaneye yatırılan adölesan hastalarda hastaneye yatış sırasında yüksek SIInin artmış yoğun bakım kabulü ile ilişkili olduğunu göstermektedir. Bu bulguları doğrulamak ve geçerli kılmak için ek çalışmalara ihtiyaç duyulmasına rağmen, bu çalışmadan elde edilen kanıtlar, COVID-19 hastalarında hastane içi sonuçların değerli bir prognostik göstergesi olarak SIInin potansiyel faydasını desteklemektedir.

Makale detayları

Prognostic value of systemic immune-inflammatory index in hospitalized adolescent COVID-19 patients

Yazarlar:

Hanife Tuğçe Çağlar | Sevgi Pekcan | Gökçen Ünal | Fatih Ercan | Aslı İmran Yılmaz | Ozge Metin | Mustafa Gençeli | Mehmet Özdemir | Fatma Nur Ayman | Suat Savaş | Bahar Ece Tokdemir

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.35 Issue 1, pp.123-128

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339640

pISSN:

2602-3741

Adolescent

COVID-19

prognosis

systemic immune-inflammatory indexadölesan

COVID-19

prognoz

sistemik immün-inflamatuvar indeks

Sayı

Makale detayları

Yazarlar: Hanife Tuğçe Çağlar | Sevgi Pekcan | Gökçen Ünal | Fatih Ercan | Aslı İmran Yılmaz | Ozge Metin | Mustafa Gençeli | Mehmet Özdemir | Fatma Nur Ayman | Suat Savaş | Bahar Ece Tokdemir

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Genel Tıp Dergisi Vol.35 Issue 1, pp.123-128

Belge Tipi: Makale

Yayın Tarihi: 2/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001339640

pISSN: 2602-3741

Sayı

Yazarlar:

Hanife Tuğçe Çağlar | Sevgi Pekcan | Gökçen Ünal | Fatih Ercan | Aslı İmran Yılmaz | Ozge Metin | Mustafa Gençeli | Mehmet Özdemir | Fatma Nur Ayman | Suat Savaş | Bahar Ece Tokdemir

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Genel Tıp Dergisi Vol.35 Issue 1, pp.123-128

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001339640

pISSN:

2602-3741