N-Acetylcysteine Improves Acrylamide-Induced Changes in Ovarian Tissue and Serum Levels of Pituitary-Ovarian Axis Hormones in Adult Rats

Marziyeh NAİMİ; Mehrdad SHARİATİ; Syrus NAİMİ; Mohammad Amin EDALATMANESH

Makale detayları

N-Acetylcysteine Improves Acrylamide-Induced Changes in Ovarian Tissue and Serum Levels of Pituitary-Ovarian Axis Hormones in Adult Rats

Yazarlar:

Marziyeh NAİMİ | Mehrdad SHARİATİ | Syrus NAİMİ | Mohammad Amin EDALATMANESH

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2019 Vol.78 Issue 2, pp.75-81

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000424415

eISSN:

2618-6144

pISSN:

2602-2575

Özet:

 

Objective: The purpose of this study was to evaluate the protective effect of N-acetylcystein (NAC) on ovarian tissue and serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and progesterone in Acrylamide (AA)treated adult rats. Materials and Methods: Forty-two adult female Wistar rats were randomly assigned into 7 groups of 6 including: a control group without treatment, a placebo group received distilled water intraperitoneally, an AA group received 50 mg/kg by oral gavage, a NAC group received 40 mg/kg intraperitoneally, an AA+NAC10, AA+NAC20 and an AA+NAC40 groups received 10, 20 and 40 mg/kg of NAC intraperitoneally, respectively and then also received 50 mg/kg AA by oral gavage for 28 days. Serum levels of FSH, LH, estradiol and progesterone were measured by radioimmunoassay method and ovarian tissue was evaluated histopathologically. Results: Administrating AA alone decreased the number of ovarian follicles, corpus luteum and the levels of FSH, estradiol and progesterone, while increased the number of atretic follicles and LH level compared to the control, placebo and NAC groups (p0.05). Following AA+NAC20 and AA+NAC40 administration and not AA+NAC10, the number of ovarian follicles, corpus luteum and also the levels of FSH, estradiol and progesterone increased, while the number of atretic follicles and LH level decreased (p<0.05), which was in a dose-dependent manner compared to the AA group. Conclusion: NAC could recover the AA female rat reproductive toxicity in a dose-dependent manner, and improved folliculogenesis. .

Makale detayları

N-Acetylcysteine Improves Acrylamide-Induced Changes in Ovarian Tissue and Serum Levels of Pituitary-Ovarian Axis Hormones in Adult Rats

Yazarlar: Marziyeh NAİMİ | Mehrdad SHARİATİ | Syrus NAİMİ | Mohammad Amin EDALATMANESH

Yayıncı: Istanbul University

Dergi: European Journal of Biology 2019 Vol.78 Issue 2, pp.75-81

Belge Tipi: Makale

Yayın Tarihi: 12/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000424415

eISSN: 2618-6144

pISSN: 2602-2575

Sayı

Yazarlar:

Marziyeh NAİMİ | Mehrdad SHARİATİ | Syrus NAİMİ | Mohammad Amin EDALATMANESH

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2019 Vol.78 Issue 2, pp.75-81

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000424415

eISSN:

2618-6144

pISSN:

2602-2575