Phytochemicals and antimicrobial properties of traditional medicinal plants in Bosnia and Herzegovina

N.A.

Makale detayları

Phytochemicals and antimicrobial properties of traditional medicinal plants in Bosnia and Herzegovina

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.722-741

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341720

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In traditional medicine, plants are widely utilized as sources of bioactive compounds for treating various diseases. This study aimed to evaluate the secondary metabolite composition, antioxidant properties, and antimicrobial effects of 38 medicinal plants commonly used in Bosnia and Herzegovina. Plants were collected from natural habitats, and dried plant material from different organs, selected based on their traditional medicinal use, was used for the extraction of bioactive compounds with 80 ethanol. The extracts were analysed for phenolic, flavonoid, and tannin content, as well as antioxidant capacity using DPPH and FRAP assays and antimicrobial activity. The antimicrobial activity of all 38 plants was initially screened using the disc diffusion method. For plants showing significant antimicrobial activity inhibition zones  20 mm, the minimum inhibitory concentration MIC and minimum bactericidal concentration MBC were determined. All analysed plants exhibited high phenolic content, with Melissa officinalis leaf extract, Filipendula vulgaris flower extract, and Rubus plicatus leaf extract containing over 300 mg GAEg DW. According to the DPPH assay, high antioxidant capacity was observed in extracts from the leaves of Fragaria vesca, Prunus armeniaca, Rubus plicatus, and R. ideus, as well as in Rosa canina fruit and Filipendula vulgaris flower extracts, with values reaching 702.39 mg TEg DW. Among the 38 tested plants, 16 exhibited high antimicrobial activity with inhibition zones greater than 20 mm. To ensure both the efficacy and safety of these plants, further studies on their toxicity, particularly dose-dependent toxicity, are necessary.

 In traditional medicine, plants are widely utilized as sources of bioactive compounds for treating various diseases. This study aimed to evaluate the secondary metabolite composition, antioxidant properties, and antimicrobial effects of 38 medicinal plants commonly used in Bosnia and Herzegovina. Plants were collected from natural habitats, and dried plant material from different organs, selected based on their traditional medicinal use, was used for the extraction of bioactive compounds with 80 ethanol. The extracts were analysed for phenolic, flavonoid, and tannin content, as well as antioxidant capacity using DPPH and FRAP assays and antimicrobial activity. The antimicrobial activity of all 38 plants was initially screened using the disc diffusion method. For plants showing significant antimicrobial activity inhibition zones  20 mm, the minimum inhibitory concentration MIC and minimum bactericidal concentration MBC were determined. All analysed plants exhibited high phenolic content, with Melissa officinalis leaf extract, Filipendula vulgaris flower extract, and Rubus plicatus leaf extract containing over 300 mg GAEg DW. According to the DPPH assay, high antioxidant capacity was observed in extracts from the leaves of Fragaria vesca, Prunus armeniaca, Rubus plicatus, and R. ideus, as well as in Rosa canina fruit and Filipendula vulgaris flower extracts, with values reaching 702.39 mg TEg DW. Among the 38 tested plants, 16 exhibited high antimicrobial activity with inhibition zones greater than 20 mm. To ensure both the efficacy and safety of these plants, further studies on their toxicity, particularly dose-dependent toxicity, are necessary.

 In traditional medicine, plants are widely utilized as sources of bioactive compounds for treating various diseases. This study aimed to evaluate the secondary metabolite composition, antioxidant properties, and antimicrobial effects of 38 medicinal plants commonly used in Bosnia and Herzegovina. Plants were collected from natural habitats, and dried plant material from different organs, selected based on their traditional medicinal use, was used for the extraction of bioactive compounds with 80 ethanol. The extracts were analysed for phenolic, flavonoid, and tannin content, as well as antioxidant capacity using DPPH and FRAP assays and antimicrobial activity. The antimicrobial activity of all 38 plants was initially screened using the disc diffusion method. For plants showing significant antimicrobial activity inhibition zones  20 mm, the minimum inhibitory concentration MIC and minimum bactericidal concentration MBC were determined. All analysed plants exhibited high phenolic content, with Melissa officinalis leaf extract, Filipendula vulgaris flower extract, and Rubus plicatus leaf extract containing over 300 mg GAEg DW. According to the DPPH assay, high antioxidant capacity was observed in extracts from the leaves of Fragaria vesca, Prunus armeniaca, Rubus plicatus, and R. ideus, as well as in Rosa canina fruit and Filipendula vulgaris flower extracts, with values reaching 702.39 mg TEg DW. Among the 38 tested plants, 16 exhibited high antimicrobial activity with inhibition zones greater than 20 mm. To ensure both the efficacy and safety of these plants, further studies on their toxicity, particularly dose-dependent toxicity, are necessary.

 In traditional medicine, plants are widely utilized as sources of bioactive compounds for treating various diseases. This study aimed to evaluate the secondary metabolite composition, antioxidant properties, and antimicrobial effects of 38 medicinal plants commonly used in Bosnia and Herzegovina. Plants were collected from natural habitats, and dried plant material from different organs, selected based on their traditional medicinal use, was used for the extraction of bioactive compounds with 80 ethanol. The extracts were analysed for phenolic, flavonoid, and tannin content, as well as antioxidant capacity using DPPH and FRAP assays and antimicrobial activity. The antimicrobial activity of all 38 plants was initially screened using the disc diffusion method. For plants showing significant antimicrobial activity inhibition zones  20 mm, the minimum inhibitory concentration MIC and minimum bactericidal concentration MBC were determined. All analysed plants exhibited high phenolic content, with Melissa officinalis leaf extract, Filipendula vulgaris flower extract, and Rubus plicatus leaf extract containing over 300 mg GAEg DW. According to the DPPH assay, high antioxidant capacity was observed in extracts from the leaves of Fragaria vesca, Prunus armeniaca, Rubus plicatus, and R. ideus, as well as in Rosa canina fruit and Filipendula vulgaris flower extracts, with values reaching 702.39 mg TEg DW. Among the 38 tested plants, 16 exhibited high antimicrobial activity with inhibition zones greater than 20 mm. To ensure both the efficacy and safety of these plants, further studies on their toxicity, particularly dose-dependent toxicity, are necessary.

Makale detayları

Phytochemicals and antimicrobial properties of traditional medicinal plants in Bosnia and Herzegovina

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.722-741

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341720

pISSN:

2630-6344

Bosnia and Herzegovina

ethnopharmacy

secondary metabolites

antioxidant activity

antimicrobial activity

Sayı

Makale detayları

Phytochemicals and antimicrobial properties of traditional medicinal plants in Bosnia and Herzegovina

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 2, pp.722-741

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341720

pISSN: 2630-6344

Bosnia and Herzegovina

ethnopharmacy

secondary metabolites

antioxidant activity

antimicrobial activity

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 2, pp.722-741

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341720

pISSN:

2630-6344