Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Onur Hurşitoğlu; Ergul Belge Kurutas; Ömer Faruk Uygur; Nurinnisa Öztürk

Makale detayları

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Yazarlar:

Onur Hurşitoğlu | Ergul Belge Kurutas | Ömer Faruk Uygur | Nurinnisa Öztürk

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 4, pp.426-429

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293928

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease. In this context, GPER, which is defined in the reproductive system as well as the nervous system, endocrine system and cardiovascular system, and mediates the neurological benefits of estradiol; It is important to better understand its role in this disease. Method: In this study, we aimed to compare serum GPER levels in euthymic bipolar disorder and healthy controls matched for age, sex and body mass index. Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the control groups. Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.

 Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease. In this context, GPER, which is defined in the reproductive system as well as the nervous system, endocrine system and cardiovascular system, and mediates the neurological benefits of estradiol; It is important to better understand its role in this disease. Method: In this study, we aimed to compare serum GPER levels in euthymic bipolar disorder and healthy controls matched for age, sex and body mass index. Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the control groups. Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.

 Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease. In this context, GPER, which is defined in the reproductive system as well as the nervous system, endocrine system and cardiovascular system, and mediates the neurological benefits of estradiol; It is important to better understand its role in this disease. Method: In this study, we aimed to compare serum GPER levels in euthymic bipolar disorder and healthy controls matched for age, sex and body mass index. Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the control groups. Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.

 Amaç: Literatürde östrojen ve reseptörlerinin, hastalığın seyri, şiddeti ve pik dönemlerindeki cinsiyet farklılıkları nedeniyle bipolar bozukluğun etiyopatogenezinde önemli rol oynadığına dair artan kanıtlar bulunmaktadır. Bu bağlamda üreme sisteminin yanı sıra sinir sistemi, endokrin sistem ve kardiyovasküler sistemde de tanımlanan ve östradiolün nörolojik faydalarına aracılık eden GPERin bu hastalıktaki rolünü daha iyi anlamak önemlidir. Yöntemler: Bu çalışmada, ötimik dönemdeki bipolar bozukluk hastaları ile yaş, cinsiyet ve vücut kitle indeksi açısından eşleştirilmiş sağlıklı kontrollerde serum GPER düzeylerini karşılaştırmayı amaçladık. Sonuçlar: Bu çalışmada hasta gruplarında kontrol gruplarına göre her iki cinsiyette ayrı ayrı ve toplamda serum GPER düzeylerinin düşük olduğunu saptadık. Tartışma: Sonuçlarımız ön çalışma olarak değerlendirilmeli ve daha büyük örneklemlerle daha homojen gruplarda tekrarlanmalıdır. Ek olarak, G1in depresif dönemdeki bipolar hastalarda terapötik etkinliği konusunda daha fazla araştırma yapılması gerektiğine inanıyoruz.

Makale detayları

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Yazarlar:

Onur Hurşitoğlu | Ergul Belge Kurutas | Ömer Faruk Uygur | Nurinnisa Öztürk

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 4, pp.426-429

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293928

pISSN:

2602-3741

GPER

Estrogen Receptors

Estradiol

GenderGPER

Östrojen Reseptörleri

Estradiol

Cinsiyet

Sayı

Makale detayları

Yazarlar: Onur Hurşitoğlu | Ergul Belge Kurutas | Ömer Faruk Uygur | Nurinnisa Öztürk

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Genel Tıp Dergisi Vol.33 Issue 4, pp.426-429

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293928

pISSN: 2602-3741

Sayı

Yazarlar:

Onur Hurşitoğlu | Ergul Belge Kurutas | Ömer Faruk Uygur | Nurinnisa Öztürk

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 4, pp.426-429

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293928

pISSN:

2602-3741