Plasma Antioxidant Status and Nitrate Levels in  Patients With Hypertension and  Coronary Heart Disease

Bülent SÖZMEN

Makale detayları

Plasma Antioxidant Status and Nitrate Levels in Patients With Hypertension and Coronary Heart Disease

Yazarlar:

Bülent SÖZMEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.525-532

Belge Tipi:

Makale

Yayın Tarihi:

4/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758261

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

In this study, we investigated first;  the possible involvement of nitric oxide and  antioxidant enzyme level in the pathogenesis  of essential hypertension and second we  investigated serum nitrite-nitrate and  antioxidant enzyme activities and lipid  profiles (total, HDL and LDL cholesterol,  trygliceride) to determine the relationship  between these parameters in atherosclerosis.  13 patients with coronary heart disease, 18  patients with essential hypertension and 16  age-matched health subjects were taken into  this study. Plasma nitrite, nitrate levels were  measured by Griess reaction, erythrocyter  superoxide dismutase and catalase activities  were determined by the methods of  Misra&Fridovich and Aebi, respectively.  Serum lipid analysis were performed in the  autoanalyser. A decrease in superoxide  dismutase activity and nitrite&nitrate levels,  along with an increase in total cholesterol,  LDL-cholesterol and triglyceride values were  found in patients with hypertension. There  was a positive correlation between nitrite and  HDL-cholesterol levels in the same patient  group. A decrease in superoxide dismutase  activity and nitrate levels and no significant  difference in nitrate, LDL-cholesterol, total  cholesterol, triglyceride levels were detected  in patients with coronary heart disease. On  the other hand, catalase activities in both of  the groups did not show any significant  difference. These findings focus the attention  to interactions between nitric oxide,  antioxidant status and atherogenesis and  propose that nitric oxide may be important  physiopathologically in essential hypertension  and atherosclerotic heart failure.

 

In this study, we investigated first;  the possible involvement of nitric oxide and  antioxidant enzyme level in the pathogenesis  of essential hypertension and second we  investigated serum nitrite-nitrate and  antioxidant enzyme activities and lipid  profiles (total, HDL and LDL cholesterol,  trygliceride) to determine the relationship  between these parameters in atherosclerosis.  13 patients with coronary heart disease, 18  patients with essential hypertension and 16  age-matched health subjects were taken into  this study. Plasma nitrite, nitrate levels were  measured by Griess reaction, erythrocyter  superoxide dismutase and catalase activities  were determined by the methods of  Misra&Fridovich and Aebi, respectively.  Serum lipid analysis were performed in the  autoanalyser. A decrease in superoxide  dismutase activity and nitrite&nitrate levels,  along with an increase in total cholesterol,  LDL-cholesterol and triglyceride values were  found in patients with hypertension. There  was a positive correlation between nitrite and  HDL-cholesterol levels in the same patient  group. A decrease in superoxide dismutase  activity and nitrate levels and no significant  difference in nitrate, LDL-cholesterol, total  cholesterol, triglyceride levels were detected  in patients with coronary heart disease. On  the other hand, catalase activities in both of  the groups did not show any significant  difference. These findings focus the attention  to interactions between nitric oxide,  antioxidant status and atherogenesis and  propose that nitric oxide may be important  physiopathologically in essential hypertension  and atherosclerotic heart failure.

Makale detayları

Plasma Antioxidant Status and Nitrate Levels in Patients With Hypertension and Coronary Heart Disease

Yazarlar:

Bülent SÖZMEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.525-532

Belge Tipi:

Makale

Yayın Tarihi:

4/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758261

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Nitric oxide

antioxidant enzymes

hypertension

coronary heart disease.

Sayı

Makale detayları

Plasma Antioxidant Status and Nitrate Levels in Patients With Hypertension and Coronary Heart Disease

Yazarlar: Bülent SÖZMEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.525-532

Belge Tipi: Makale

Yayın Tarihi: 4/1998

Belge Dili: Türkçe

Document ID (Org No.): 2000758261

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Nitric oxide

antioxidant enzymes

hypertension

coronary heart disease.

Sayı

Yazarlar:

Bülent SÖZMEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 5, pp.525-532

Belge Tipi:

Makale

Yayın Tarihi:

4/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758261

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144