Detection of the differences in the apparent diffusion coefficient values in different  histopathological types of malignant breast lesions and comparison of cellular region/  stroma ratio and histopathological results

Nevin Köremezli KESKİN; Pinar BALCI; IŞIL BAŞARA AKIN; Esra Yavuz GÜRKAN; ALİ İBRAHİM SEVİNÇ; Merih Güray DURAK; AYÇA ERŞEN DANYELİ

Makale detayları

Detection of the differences in the apparent diffusion coefficient values in different histopathological types of malignant breast lesions and comparison of cellular region/ stroma ratio and histopathological results

Yazarlar:

Nevin Köremezli KESKİN | Pinar BALCI | IŞIL BAŞARA AKIN | Esra Yavuz GÜRKAN | ALİ İBRAHİM SEVİNÇ | Merih Güray DURAK | AYÇA ERŞEN DANYELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.817-825

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750648

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to compare the apparent diffusion coefficient (ADC) values of malignant breast lesions with different  histopathological types on diffusion-weighted imaging (DWI) and the cellular region/stroma (CR/S) ratio and histopathological results.  Materials and methods: Breast diffusion-weighted magnetic resonance findings of 59 patients were retrospectively analyzed for  malignant breast lesions. The CR/S ratio was calculated using breast wide-excisional biopsy or mastectomy specimens.  Results: Receiver operating characteristic analysis was performed for malignant lesions and subtypes. An ADC threshold of 1.260 ×  10-3 mm2/s was set to detect invasive ductal carcinoma with 80.8% sensitivity and 81.4% specificity. An ADC threshold of 1.391 × 10-3  mm2/s was set to detect invasive lobular carcinoma lesions with 88.2% sensitivity and 79.5% specificity. The ADC value for lesions with  low CR/S ratio (n = 21) was 1.135 ± 0.429 × 10-3 mm2/s and it was 1.155 ± 0.429 × 10-3 mm2/s in the high CR/S ratio group (n = 18).  Conclusion: ADC value calculation does not seem to be used as an alternative for histopathological detection, which is the gold standard  for the differentiation of subtypes of malignant breast cancer. In addition, since there is a positive correlation between CR/S ratio and  ADC values, it may be a strong marker to evaluate the stromal component of lesions.

Makale detayları

Detection of the differences in the apparent diffusion coefficient values in different histopathological types of malignant breast lesions and comparison of cellular region/ stroma ratio and histopathological results

Yazarlar: Nevin Köremezli KESKİN | Pinar BALCI | IŞIL BAŞARA AKIN | Esra Yavuz GÜRKAN | ALİ İBRAHİM SEVİNÇ | Merih Güray DURAK | AYÇA ERŞEN DANYELİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.817-825

Belge Tipi: Makale

Yayın Tarihi: 7/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750648

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Nevin Köremezli KESKİN | Pinar BALCI | IŞIL BAŞARA AKIN | Esra Yavuz GÜRKAN | ALİ İBRAHİM SEVİNÇ | Merih Güray DURAK | AYÇA ERŞEN DANYELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.817-825

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750648

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144