Effect of Acetaminofen Versus Lornoxicam Admistration on Oxidative Stress in Rat Hepatic and Renal Tissues

Mustafa ATAC; Saban SEZEN; Mustafa BİLGE; Berrin ISİK; Mustafa ARSLAN; Faruk COMU; Mustafa KAVUTCU; Dervis YİLMAZ

Makale detayları

Effect of Acetaminofen Versus Lornoxicam Admistration on Oxidative Stress in Rat Hepatic and Renal Tissues

Yazarlar:

Mustafa ATAC | Saban SEZEN | Mustafa BİLGE | Berrin ISİK | Mustafa ARSLAN | Faruk COMU | Mustafa KAVUTCU | Dervis YİLMAZ

Yayıncı:

Zafer AKAN

Dergi:

Medical Science and Discovery 2015 Vol.2 Issue 4, pp.244-53

Belge Tipi:

Makale

Yayın Tarihi:

4/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000826949

Sıklık:

Aylık

eISSN:

2148-6832

pISSN:

2148-6832

Özet:

 


Background and aim: The aim of study was to assess the oxidative status in rat hepatic and renal tissues after intraperitoneal administration of acetaminophen (AP) versus lornoxicam (L).

Materials and Methods: For this purpose 18 Wistar Albino rats were randomly divided into 3 groups; each group consists of 6 rats. Group Control (Group C) remain untreated, comprises healthy rats. Group AP received AP (100 mg kg-1) and Group L received L (1.3 mg kg-1) intraperitoneally. Oxidative status was evaluated by MDA, SOD, GST and CAT in hepatic and renal tissues. Furthermore histopathalogical evaluation was performed in both tissues.

Results: The lornoxicam received rats (Group L) showed significantly increased level of MDA and GST [(p=0.015), (p=0.048) respectively],decreased level of SOD (p=0.02)in liver tissue. Renal tissue MDA, SOD and GST activity and CAT levels were similar in groups [(p=0.168), (p=0.270), (p=0.686) respectively]. Histopathalogically Group AP and Group L more damaged than in Group C. Hepatic injury was moderate level in two groups. Minimal injury was observed in group AP. Renal injury in group L more than the Group AP.

Conclusion: The results suggest that hepatotoxic effects of lornoxicam more than the AP while no remarkable difference nephrotoxicity.

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Makale detayları

Effect of Acetaminofen Versus Lornoxicam Admistration on Oxidative Stress in Rat Hepatic and Renal Tissues

Yazarlar: Mustafa ATAC | Saban SEZEN | Mustafa BİLGE | Berrin ISİK | Mustafa ARSLAN | Faruk COMU | Mustafa KAVUTCU | Dervis YİLMAZ

Yayıncı: Zafer AKAN

Dergi: Medical Science and Discovery 2015 Vol.2 Issue 4, pp.244-53

Belge Tipi: Makale

Yayın Tarihi: 4/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000826949

Sıklık: Aylık

eISSN: 2148-6832

pISSN: 2148-6832

Sayı

Yazarlar:

Mustafa ATAC | Saban SEZEN | Mustafa BİLGE | Berrin ISİK | Mustafa ARSLAN | Faruk COMU | Mustafa KAVUTCU | Dervis YİLMAZ

Yayıncı:

Zafer AKAN

Dergi:

Medical Science and Discovery 2015 Vol.2 Issue 4, pp.244-53

Belge Tipi:

Makale

Yayın Tarihi:

4/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000826949

Sıklık:

Aylık

eISSN:

2148-6832

pISSN:

2148-6832