Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

Yaşar DÜRÜST; Hamza KARAKUŞ; Muhsine Zeynep YAVUZ; Ali Akçahan GEPDİREMEN

doi:https://doi.org/10.3906/kim-1309-59

Makale detayları

Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

Yazarlar:

Yaşar DÜRÜST | Hamza KARAKUŞ | Muhsine Zeynep YAVUZ | Ali Akçahan GEPDİREMEN

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 5, pp.739-755

Belge Tipi:

Makale

Yayın Tarihi:

4/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000727067

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1309-59

Özet:

 

1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul\-fonyl)-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (1H, 13C, 2D), mass spectra, and physical characteristics (mp and Rf values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.

 

1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul\-fonyl)-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (1H, 13C, 2D), mass spectra, and physical characteristics (mp and Rf values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.

Makale detayları

Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

Yazarlar: Yaşar DÜRÜST | Hamza KARAKUŞ | Muhsine Zeynep YAVUZ | Ali Akçahan GEPDİREMEN

Yayıncı: TUBITAK

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Turkish Journal of Chemistry 2014 Vol.38 Issue 5, pp.739-755

Belge Tipi: Makale

Yayın Tarihi: 4/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000727067

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1309-59

Sayı

Yazarlar:

Yaşar DÜRÜST | Hamza KARAKUŞ | Muhsine Zeynep YAVUZ | Ali Akçahan GEPDİREMEN

Yayıncı:

TUBITAK

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 5, pp.739-755

Belge Tipi:

Makale

Yayın Tarihi:

4/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000727067

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1309-59